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12 results on '"Grünig, Ekkehard"'

1. Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era

Author

Gerhardt, Felix, Fiessler, Eva, Olsson, Karen M., Kayser, Moritz Z., Kovacs, Gabor, Gall, Henning, Ghofrani, H. Ardeschir, Badr Eslam, Roza, Lang, Irene M., Benjamin, Nicola, Grünig, Ekkehard, Halank, Michael, Lange, Tobias J., Ulrich, Silvia, Leuchte, Hanno, Held, Matthias, Klose, Hans, Ewert, Ralf, Wilkens, Heinrike, Pizarro, Carmen, Skowasch, Dirk, Wissmüller, Max, Hellmich, Martin, Olschewski, Horst, Hoeper, Marius M., and Rosenkranz, Stephan

Published
2024
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2. Abstract 12841: Mutations in the BMPR2 Gene Are Associated With Worse Survival in Patients With Pulmonary Arterial Hypertension

Author

Evans, Jonathan D, primary, Girerd, Barbara, additional, Montani, David, additional, Jing, Zhi-Cheng, additional, Yan, Yi, additional, Wang, Xiao-Jian, additional, Galiè, Nazzareno, additional, Manes, Alessandra, additional, Palazzini, Massimiliano, additional, Austin, Eric D, additional, Wheeler, Lisa A, additional, Elliott, Greg, additional, Nakayama, Ikue, additional, Asano, Koichiro, additional, Grünig, Ekkehard, additional, Eichstaedt, Christina, additional, Hinderhofer, Katrin, additional, Wolf, Matthias, additional, Rosenzweig, Erika B, additional, Chung, Wendy K, additional, Soubrier, Florent, additional, Simonneau, Gerald, additional, Gräf, Stefan, additional, Kaptoge, Stephen, additional, Di Angelantonio, Emanuele, additional, Humbert, Marc, additional, and Morrell, Nicholas W, additional

Published
2015
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3. Response to Letters Regarding Article, “Anticoagulation and Survival in Pulmonary Arterial Hypertension: Results From the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)”

Author

Olsson, Karen M., primary, Delcroix, Marion, additional, Ghofrani, H. Ardeschir, additional, Tiede, Henning, additional, Huscher, Doerte, additional, Speich, Rudolf, additional, Grünig, Ekkehard, additional, Staehler, Gerd, additional, Rosenkranz, Stephan, additional, Halank, Michael, additional, Held, Matthias, additional, Lange, Tobias J., additional, Behr, Juergen, additional, Klose, Hans, additional, Claussen, Martin, additional, Ewert, Ralf, additional, Opitz, Christian F., additional, Vizza, C. Dario, additional, Scelsi, Laura, additional, Vonk-Noordegraaf, Anton, additional, Kaemmerer, Harald, additional, Gibbs, J. Simon R., additional, Coghlan, Gerry, additional, Pepke-Zaba, Joanna, additional, Schulz, Uwe, additional, Gorenflo, Matthias, additional, Pittrow, David, additional, and Hoeper, Marius M., additional

Published
2014
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4. Anticoagulation and Survival in Pulmonary Arterial Hypertension

Author

Olsson, Karen M., primary, Delcroix, Marion, additional, Ghofrani, H. Ardeschir, additional, Tiede, Henning, additional, Huscher, Doerte, additional, Speich, Rudolf, additional, Grünig, Ekkehard, additional, Staehler, Gerd, additional, Rosenkranz, Stephan, additional, Halank, Michael, additional, Held, Matthias, additional, Lange, Tobias J., additional, Behr, Juergen, additional, Klose, Hans, additional, Claussen, Martin, additional, Ewert, Ralf, additional, Opitz, Christian F., additional, Vizza, C. Dario, additional, Scelsi, Laura, additional, Vonk-Noordegraaf, Anton, additional, Kaemmerer, Harald, additional, Gibbs, J. Simon R., additional, Coghlan, Gerry, additional, Pepke-Zaba, Joanna, additional, Schulz, Uwe, additional, Gorenflo, Matthias, additional, Pittrow, David, additional, and Hoeper, Marius M., additional

Published
2014
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5. Assessment and Prognostic Relevance of Right Ventricular Contractile Reserve in Patients With Severe Pulmonary Hypertension

Author

Grünig, Ekkehard, primary, Tiede, Henning, additional, Enyimayew, Esi Otuwa, additional, Ehlken, Nicola, additional, Seyfarth, Hans-Jürgen, additional, Bossone, Eduardo, additional, D’Andrea, Antonello, additional, Naeije, Robert, additional, Olschewski, Horst, additional, Ulrich, Silvia, additional, Nagel, Christian, additional, Halank, Michael, additional, and Fischer, Christine, additional

Published
2013
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7. Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension

Author

Hoeper, Marius M., primary, Barst, Robyn J., additional, Bourge, Robert C., additional, Feldman, Jeremy, additional, Frost, Adaani E., additional, Galié, Nazzareno, additional, Gómez-Sánchez, Miguel Angel, additional, Grimminger, Friedrich, additional, Grünig, Ekkehard, additional, Hassoun, Paul M., additional, Morrell, Nicholas W., additional, Peacock, Andrew J., additional, Satoh, Toru, additional, Simonneau, Gérald, additional, Tapson, Victor F., additional, Torres, Fernando, additional, Lawrence, David, additional, Quinn, Deborah A., additional, and Ghofrani, Hossein-Ardeschir, additional

Published
2013
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8. Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension

Author

Grünig, Ekkehard, primary, Weissmann, Sylvia, additional, Ehlken, Nicola, additional, Fijalkowska, Anna, additional, Fischer, Christine, additional, Fourme, Thierry, additional, Galié, Nazzareno, additional, Ghofrani, Ardeschir, additional, Harrison, Rachel E., additional, Huez, Sandrine, additional, Humbert, Marc, additional, Janssen, Bart, additional, Kober, Jaroslaw, additional, Koehler, Rolf, additional, Machado, Rajiv D., additional, Mereles, Derliz, additional, Naeije, Robert, additional, Olschewski, Horst, additional, Provencher, Steeve, additional, Reichenberger, Frank, additional, Retailleau, Kathleen, additional, Rocchi, Guido, additional, Simonneau, Gérald, additional, Torbicki, Adam, additional, Trembath, Richard, additional, and Seeger, Werner, additional

Published
2009
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9. Exercise and Respiratory Training Improve Exercise Capacity and Quality of Life in Patients With Severe Chronic Pulmonary Hypertension

Author

Mereles, Derliz, primary, Ehlken, Nicola, additional, Kreuscher, Sandra, additional, Ghofrani, Stefanie, additional, Hoeper, Marius M., additional, Halank, Michael, additional, Meyer, F. Joachim, additional, Karger, Gabriele, additional, Buss, Jan, additional, Juenger, Jana, additional, Holzapfel, Nicole, additional, Opitz, Christian, additional, Winkler, Jörg, additional, Herth, Felix F.J., additional, Wilkens, Heinrike, additional, Katus, Hugo A., additional, Olschewski, Horst, additional, and Grünig, Ekkehard, additional

Published
2006
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11. Dilated Cardiomyopathy and Sensorineural Hearing Loss

Author

Schönberger, Jost, primary, Levy, Hara, additional, Grünig, Ekkehard, additional, Sangwatanaroj, Somkiat, additional, Fatkin, Diane, additional, MacRae, Calum, additional, Stäcker, Hinrich, additional, Halpin, Christopher, additional, Eavey, Roland, additional, Philbin, Edward F., additional, Katus, Hugo, additional, Seidman, J. G., additional, and Seidman, Christine E., additional

Published
2000
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12. Assessment and Prognostic Relevance of Right Ventricular Contractile Reserve in Patients With Severe Pulmonary Hypertension

Author

Hans-Jürgen Seyfarth, Antonello D'Andrea, Horst Olschewski, Eduardo Bossone, Henning Tiede, Ekkehard Grünig, Nicola Ehlken, Silvia Ulrich, Robert Naeije, Christine Fischer, Michael Halank, Christian Nagel, Esi Otuwa Enyimayew, Grunig, E, Tiede, H, Enyimayew, Eo, Ehlken, N, Seyfarth, Hj, Bossone, E, D'Andrea, A, Naeije, R, Olschewski, H, Ulrich, S, Nagel, C, Halank, M, Fischer, C, University of Zurich, and Grünig, Ekkehard

Subjects
Adult, Male, medicine.medical_specialty, Hypertension, Pulmonary, Physical Exertion, 610 Medicine & health, Blood Pressure, 030204 cardiovascular system & hematology, Doppler echocardiography, Severity of Illness Index, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, 2737 Physiology (medical), Oxygen Consumption, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine.artery, Severity of illness, medicine, Stress Echocardiography, Humans, Prospective Studies, Prospective cohort study, Aged, Heart Failure, medicine.diagnostic_test, business.industry, Middle Aged, Prognosis, medicine.disease, Myocardial Contraction, Pulmonary hypertension, Echocardiography, Doppler, 3. Good health, Blood pressure, 030228 respiratory system, Heart failure, Pulmonary artery, Exercise Test, Ventricular Function, Right, Cardiology, Female, 10178 Clinic for Pneumology, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Background— This study sought to analyze a new approach to assess exercise-induced pulmonary artery systolic pressure (PASP) increase by means of stress Doppler echocardiography as a possible measure of right ventricular contractile reserve in patients with severe pulmonary hypertension and right heart failure. Methods and Results— In this prospective study, patients with invasively diagnosed pulmonary arterial hypertension or inoperable chronic thromboembolic pulmonary hypertension and impaired right ventricular pump function despite a stable targeted pulmonary arterial hypertension medication underwent a broad panel of noninvasive assessments, including stress echocardiography and cardiopulmonary exercise testing. On the basis of the assumption that exercise-induced PASP is a measure of right ventricular contractile reserve, patients were classified into 2 groups according to an exercise-induced PASP increase above or below the median. Patients were followed up for 3.0±1.8 years. Univariate and multivariate analyses were used for factors predicting survival. Of 124 patients, 66 were below the median exercise-induced PASP increase of 30 mm Hg (low PASP), and 58 patients were above the median (high PASP). These groups were not significantly different in terms of medication and resting hemodynamics. Low PASP was associated with a significantly lower 6-minute walking distance, peak o 2 per kilogram, and 1-, 3-, and 4-year survival rates (92%, 69%, and 48%, respectively, versus 96%, 92%, and 89%). In the multivariate Cox model analysis adjusted for age and sex, PASP increase during exercise and peak o 2 per kilogram remained independent prognostic markers (hazard ratio, 2.56 for peak o 2 per kilogram and 2.84 for PASP increase). Conclusions— Exercise-induced PASP increase is of high clinical and prognostic relevance in pulmonary hypertension patients and may indicate right ventricular contractile reserve. Stress Doppler echocardiography may be a useful tool for prognostic assessment in pulmonary hypertension patients.

Published
2013

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