1. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
- Author
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Desikan, Rahul S, Schork, Andrew J, Wang, Yunpeng, Thompson, Wesley K, Dehghan, Abbas, Ridker, Paul M, Chasman, Daniel I, McEvoy, Linda K, Holland, Dominic, Chen, Chi-Hua, Karow, David S, Brewer, James B, Hess, Christopher P, Williams, Julie, Sims, Rebecca, O'Donovan, Michael C, Choi, Seung Hoan, Bis, Joshua C, Ikram, M Arfan, Gudnason, Vilmundur, DeStefano, Anita L, van der Lee, Sven J, Psaty, Bruce M, van Duijn, Cornelia M, Launer, Lenore, Seshadri, Sudha, Pericak-Vance, Margaret A, Mayeux, Richard, Haines, Jonathan L, Farrer, Lindsay A, Hardy, John, Ulstein, Ingun Dina, Aarsland, Dag, Fladby, Tormod, White, Linda R, Sando, Sigrid B, Rongve, Arvid, Witoelar, Aree, Djurovic, Srdjan, Hyman, Bradley T, Snaedal, Jon, Steinberg, Stacy, Stefansson, Hreinn, Stefansson, Kari, Schellenberg, Gerard D, Andreassen, Ole A, Dale, Anders M, and Inflammation working group, IGAP and DemGene Investigators
- Subjects
Inflammation working group ,IGAP and DemGene Investigators ,Brain ,Humans ,Alzheimer Disease ,Inflammation ,Sulfotransferases ,Lipids ,C-Reactive Protein ,Risk Factors ,Multifactorial Inheritance ,Phenotype ,Polymorphism ,Single Nucleotide ,Aged ,Aged ,80 and over ,Female ,Male ,Dyslipidemias ,Genome-Wide Association Study ,Peroxisomal Bifunctional Enzyme ,Biomarkers ,inflammation ,lipids ,Brain Disorders ,Cardiovascular ,Neurosciences ,Neurodegenerative ,Acquired Cognitive Impairment ,Genetics ,Aging ,Alzheimer's Disease ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Prevention ,Human Genome ,Dementia ,2.1 Biological and endogenous factors ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services - Abstract
BackgroundEpidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this phenotypic association arises from a shared genetic basis.Methods and resultsUsing summary statistics (P values and odds ratios) from genome-wide association studies of >200 000 individuals, we investigated overlap in single-nucleotide polymorphisms associated with clinically diagnosed AD and C-reactive protein (CRP), triglycerides, and high- and low-density lipoprotein levels. We found up to 50-fold enrichment of AD single-nucleotide polymorphisms for different levels of association with C-reactive protein, low-density lipoprotein, high-density lipoprotein, and triglyceride single-nucleotide polymorphisms using a false discovery rate threshold
- Published
- 2015