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2. Long-Term Results of the RAPCO Trials

Author

Buxton, Brian F., Hayward, Philip A., Raman, Jai, Moten, Simon C., Rosalion, Alexander, Gordon, Ian, Seevanayagam, Siven, Matalanis, George, Benedetto, Umberto, Gaudino, Mario, and Hare, David L.

Published
2020
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5. Mechanisms, Consequences, and Prevention of Coronary Graft Failure

Author

Gaudino, Mario, Antoniades, Charalambos, Benedetto, Umberto, Deb, Saswata, Di Franco, Antonino, Di Giammarco, Gabriele, Fremes, Stephen, Glineur, David, Grau, Juan, He, Guo-Wei, Marinelli, Daniele, Ohmes, Lucas B., Patrono, Carlo, Puskas, John, Tranbaugh, Robert, Girardi, Leonard N., Taggart, David P., Ruel, Marc, and Bakaeen, Faisal G.

Published
2017
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7. Abstract 13234: Impact of Sex on Outcomes After Cardiac Surgery: A Systematic Review and Meta-Analysis

Author

Lauren K Dixon, Ettorino Di Tommaso, Arnaldo Dimagli, Shubhra Sinha, Manraj Sandhu, gianni angelini, and Benedetto Umberto

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Introduction: Despite advances in cardiac surgery, there is evidence from observational studies which suggests that females have poorer post-operative outcomes than males. This study is the first to review sex related outcomes following both coronary artery bypass graft (CABG) and valve surgery with or without combined CABG. Hypothesis: Females have worse outcomes following cardiac surgery than males. Methods: We identified 30 primary research articles reporting either short-term mortality (in-hospital/30 day), long-term mortality, post-operative stroke, sternal wound infection and post-operative myocardial infarction (MI) in both sexes following CABG and valve surgery with or without combined CABG Reported adjusted odds/hazard ratio were pooled using an inverse variance model. Results: Females were at higher risk of short-term mortality (odds ratio (OR) 1.40; 95% confidence interval (CI) 1.32-1.49; I 2 =79%) and post-operative stroke (OR 1.2; CI 1.07-1.34; I 2 =90%) when compared to males. There was no increased risk in long-term mortality (OR 1.04; 95% CI: 0.93-1.16; I 2 =82%), post-operative MI (OR 1.22; 95%CI: 0.89-1.67; I 2 =60%) or deep sternal wound infection (OR 0.92; 95%CI: 0.65-1.03, I 2 =87%). No evidence of publication bias or small study effect was found. Conclusions: Females are at a greater risk of short-term mortality and post-operative stroke than males following CABG and valve surgery with or without combined CABG. However long-term mortality is equivalent in both sexes.

Published
2021

8. Abstract 14169: Implications of Elevated Troponin on Time-to-Surgery in Non-ST Elevation Myocardial Infarction (NIHR Health Informatics Collaborative: Trop-CABG Study)

Author

Sinha, Shubhra, primary, Benedetto, Umberto, additional, Mulla, Abdulrahim, additional, Glampson, Ben, additional, Panoulas, Vasileios F., additional, Gautama, Sanjay, additional, Davies, Jim, additional, Papadimitriou, Dimitri, additional, Woods, Kerrie, additional, Elliott, Paul, additional, Hemmingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert W, additional, Melikian, Narbeh, additional, Krasopoulos, George, additional, Sayeed, Rana, additional, Wendler, Olaf, additional, Baig, Kamran, additional, Chukwuemeka, Andrew, additional, angelini, gianni, additional, Sterne, Jonathan, additional, Johnson, Tom, additional, Shah, Ajay M, additional, Perera, Divaka, additional, Patel, Riyaz, additional, Kharbanda, Rajesh, additional, Channon, Keith M, additional, Mayet, Jamil, additional, and Kaura, Amit, additional

Published
2021
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13. Abstract 3046: Protective Effect Of Preoperative Angiotensin Converting Enzyme Inhibitors On Renal Outcome Following Coronary Artery Bypass Graft Surgery. A Propensity Score-adjusted Analysis

Author

Benedetto, Umberto, primary, Refice, Simone, additional, Roscitano, Antonino, additional, Capuano, Fabio, additional, Simon, Caterina, additional, Comito, Cosimo, additional, Di Nucci, Gian Domenico, additional, Angeloni, Emiliano, additional, and Sinatra, Riccardo, additional

Published
2007
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14. Abstract 14155: Effect of Chronic Calcium-Channel Blocker Therapy After Coronary Artery Bypass With the Radial Artery: Insights From the RADIAL Database.

Author

Gaudino, Mario F, Benedetto, Umberto, Fremes, Stephen, Hare, David L, Hayward, Philip, Moat, Neil, Nasso, Giuseppe, Peric, Miodrag, Yoo, Kyung J, Speziale, Giuseppe, and Taggart, David

Subjects
*CORONARY artery bypass, *RADIAL artery, *KIDNEY failure, *MYOCARDIAL infarction, *DRUG-eluting stents, *REGRESSION analysis
Abstract

Aim: To evaluate if chronic calcium-channel blocker therapy (CCB) influences mid-term clinical and angiographic outcomes of radial artery (RA) grafts used for coronary bypass surgery (CABG). Methods: Patient-level data of all six angiographic randomized trials that evaluated RA graft status at mid-term follow-up were combined. Cox regression analysis was used to evaluate the effect of CCB on the incidence of a composite of major adverse cardiac events (death, myocardial infarction (MI) and repeat revascularization, MACE) and graft occlusion. Variables tested were: CCB, age, gender, diabetes, previous MI, surgical priority, renal insufficiency, target vessel, percentage of target vessel stenosis ≥90%, and location of proximal anastomosis. Results: The study population included 732 patients (502 CCB and 230 non-CCB). At mean follow-up of 55±20 months, graft failure occurred in 14 (5.8%) vs. 27 (13.5%) patients in the CCB and non-CCB group respectively (log-rank P<.001). After controlling for confounders, CCB therapy was significantly associated with better patency rate (HR 0.20; 95%CI 0.08-0.49; P<.0001). At mean follow-up of 60 ± 27 months, the number of MACE was 56 (11.2%) in the CCB group vs 31 (13.5%) in the non-CCB group, respectively (log-rank P=.003). After controlling for confounders, CCB therapy was independently associated with a significantly lower risk of MACE (HR 0.51; 95%CI 30-87; P=.01). Protocol-driven angiography was available in 243 CCB patients and 200 non-CCB patients. Conclusion: CCB is associated with significantly better mid-term clinical and angiographic RA outcomes. Our results support the routine use of CCB after CABG using the RA. [ABSTRACT FROM AUTHOR]

Published
2018

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