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Your search keyword '"Marklund M."' showing total 2 results
2 results on '"Marklund M."'

1. Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women.

Author

Marklund M, Leander K, Vikström M, Laguzzi F, Gigante B, Sjögren P, Cederholm T, de Faire U, Hellénius ML, and Risérus U

Subjects
Blood Glucose analysis, Cardiotonic Agents, Cardiovascular Diseases epidemiology, Cardiovascular Diseases prevention & control, Cholesterol Esters chemistry, Female, Fish Oils, Humans, Lipids blood, Male, Middle Aged, Mortality, Plant Oils, Proportional Hazards Models, Recommended Dietary Allowances, Risk Factors, Sex Factors, Surveys and Questionnaires, Sweden epidemiology, Biomarkers blood, Cardiovascular Diseases blood, Cholesterol Esters blood, Dietary Fats, Fatty Acids, Unsaturated blood
Abstract

Background: High intake of polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular disease (CVD) and mortality. Large, prospective studies including both sexes and circulating PUFAs as dietary biomarkers are needed. We investigated sex-specific associations of the major dietary PUFAs, eicosapentaenoic acid, docohexaenoic acid, linoleic acid, and α-linolenic acid, with incident CVD and all-cause mortality in a population-based cohort., Methods and Results: PUFAs in serum cholesterol esters were measured at baseline in 60-year-old Swedish women (n=2193) and men (n=2039). With the use of national registers, 484 incident CVD events (294 men and 190 women) and 456 all-cause deaths (265 men and 191 women) were identified during follow-up (median, 14.5 years) in individuals without prior CVD at baseline. Associations of PUFAs with CVD and mortality were evaluated with Cox proportional hazard models. In multivariable-adjusted models, 1-SD increases in eicosapentaenoic acid and docohexaenoic acid were associated with lower risk of incident CVD among women (hazard ratio [HR], 0.79 [95% confidence interval (CI), 0.64-0.97] and 0.74 [95% CI, 0.61-0.89], respectively). α-Linolenic acid was associated with moderately increased CVD risk in women (HR, 1.16; 95% CI, 1.02-1.32). Inverse associations with all-cause mortality were observed for eicosapentaenoic acid and docohexaenoic acid among all participants (HR, 0.81 [95% CI, 0.72-0.91] and 0.80 [95% CI, 0.72-0.89], respectively) and for linoleic acid in men (HR, 0.73; 95% CI, 0.64-0.83)., Conclusions: Serum linoleic acid and very-long-chain n-3 PUFAs, partly reflecting vegetable oil and fish intake, respectively, were inversely associated with all-cause mortality. Inverse associations of eicosapentaenoic acid and docohexaenoic acid with incident CVD were observed only in women., (© 2015 American Heart Association, Inc.)

Published
2015
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2. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality

Author

Nita G. Forouhi, Kim Overvad, Lars Lind, Robert Luben, Paulo H M Chaves, Woon-Puay Koh, Matti Marklund, Catherine Helmer, Johan Sundström, Kiesha Prem, Jaakko Mursu, Kerry L. M. Wong, Ingeborg A. Brouwer, Paul F. Jacques, Anya Kalsbeek, Mark Woodward, Helle Højmark Eriksen, Matthias B. Schulze, J.M.A. Boer, Peilin Shi, Wei Sin Yang, Eric B. Rimm, William S. Harris, Eliseo Guallar, Frank B. Hu, Kay-Tee Khaw, Jian-Min Yuan, Xia Zhou, Luc Djoussé, Maria Lankinen, Juhua Luo, W. M. Monique Verschuren, Barbara McKnight, Alexis C. Wood, Marcia C de Oliveira Otto, Tzu An Chen, Mai Lis Hellénius, Jason H Y Wu, Walter C. Willett, Matti Uusitupa, Hannia Campos, Federica Laguzzi, Bruna Gigante, Rozenn N. Lemaitre, David S. Siscovick, Brian T. Steffen, Johanna M. Geleijnse, Karin Leander, Hung-Ju Lin, Renata Micha, Hugh Tunstall-Pedoe, Ulf Risérus, Allison M. Hodge, Tamara B. Harris, Janette de Goede, Ana Baylin, Amanda M. Fretts, J. Michael Gaziano, Nicholas J. Wareham, Liana C Del Gobbo, Maria Wennberg, Bruce M. Psaty, Graham G. Giles, Qi Sun, Stella Aslibekyan, Toshiharu Ninomiya, Fumiaki Imamura, Vilmundur Gudnason, Michael Y. Tsai, Cécilia Samieri, Nathan L. Tintle, Rachel A. Murphy, Lyn M. Steffen, Janine Kröger, Rob M. van Dam, Kuo-Liong Chien, Albert V. Smith, Naglaa El-Abbadi, Yoichiro Hirakawa, Jyrki K. Virtanen, Markku Laakso, Dariush Mozaffarian, Ulf de Faire, Michael S. Nielsen, Jan-Håkan Jansson, Gudny Eiriksdottir, and Jenna Veenstra

Subjects
Male, Nutrition and Disease, 030309 nutrition & dietetics, primary prevention, 030204 cardiovascular system & hematology, Recommended Dietary Allowances, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Voeding en Ziekte, Prospective cohort study, Human Nutrition & Health, 0303 health sciences, Aspirin, education.field_of_study, Arachidonic Acid, Humane Voeding & Gezondheid, Hazard ratio, Middle Aged, 3. Good health, Primary Prevention, Observational Studies as Topic, Cardiovascular Diseases, epidemiology, Female, pooled analysis, Diet, Healthy, Cardiology and Cardiovascular Medicine, Nutritive Value, medicine.drug, Cohort study, linoleic acid, medicine.medical_specialty, Linoleic acid, Population, Lower risk, Risk Assessment, Pooled analysis, Article, Linoleic Acid, 03 medical and health sciences, diet and nutrition, SDG 3 - Good Health and Well-being, Fatty Acids, Omega-6, Physiology (medical), Internal medicine, Diabetes mellitus, Fatty Acids, Omega-3, arachidonic acid, medicine, Humans, education, VLAG, Aged, business.industry, biomarkers, Protective Factors, medicine.disease, Dietary Fats, cardiovascular diseases, chemistry, diet, business, Risk Reduction Behavior, Biomarkers
Abstract

Background: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies. Methods: We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease, ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytic plan. Levels of LA and AA, measured as the percentage of total fatty acids, were evaluated linearly according to their interquintile range (ie, the range between the midpoint of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance–weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes mellitus, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available). Results: In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15 198 incident cardiovascular events occurred among 68 659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88–0.99), 0.78 (0.70–0.85), and 0.88 (0.79–0.98), respectively, and nonsignificantly with lower coronary heart disease risk (0.94; 0.88–1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86–0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships. Conclusions: In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention.

Published
2019

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