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Your search keyword '"Messenger, John C."' showing total 12 results
Start Over Author "Messenger, John C." Journal circulation: cardiovascular interventions
12 results on '"Messenger, John C."'

3. Impact of Cerebral Embolic Protection Devices on Disabling Stroke After TAVR: Updated Results From the STS/ACC TVT Registry.

Author

Butala, Neel M., Kapadia, Samir R., Secemsky, Eric A., Gallup, Dianne, Kosinski, Andrzej S., Vemulapalli, Sreekanth, Messenger, John C., Yeh, Robert W., and Cohen, David J.

Abstract

BACKGROUND: Cerebral embolic protection devices (EPDs) were developed to mitigate the risk of stroke during transcatheter aortic valve replacement (TAVR), but their benefit remains unproven. In the PROTECTED-TAVR trial (Stroke Protection With Sentinel During Transcatheter), EPD use did not reduce periprocedural stroke (primary study outcome) but led to a 62% reduction in the secondary end point of disabling stroke. Given these results, the impact of EPDs during TAVR remains unclear. METHODS: We used STS/ACC TVT registry data to examine the association between EPD use and a proxy for disabling stroke among transfemoral TAVR patients between January 2018 and June 2023. The primary outcome was in-hospital disabling stroke--defined as stroke associated with either in-hospital death or discharge to a nonhome location. We evaluated the association between EPD use and disabling stroke using instrumental variable analysis with a site-level preference for EPD use as the instrument--a quasi-experimental approach that can support causal inference. In addition, we performed a propensity score--based comparison using overlap weighting as a secondary analysis. RESULTS: The study population consisted of 414 649 patients of whom 53 389 (12.9%) received an EPD. The unadjusted rate of in-hospital disabling stroke was 0.7% among the EPD group and 0.9% in the no-EPD group. EPD use was associated with a reduction in disabling stroke in both instrumental variable analysis (relative risk, 0.87 [95% CI, 0.73--1.00]) and propensity-weighted analysis (odds ratio, 0.79 [95% CI, 0.70--0.90]) but was not associated with a reduction in nondisabling stroke. In subgroup analyses, the benefit of EPD was greater among those with versus without prior stroke (Pinteraction<0.05 for both instrumental variable and propensity-weighted analyses). CONCLUSIONS: In the largest study to date, among patients undergoing TAVR, EPD use was associated with a small, borderline significant reduction in stroke associated with death or discharge to a nonhome location (a proxy for disabling stroke) that is likely to be causal in nature. Taken together with previous mechanistic and clinical studies, these findings provide credible evidence that EPDs benefit patients undergoing TAVR. GRAPHIC ABSTRACT: A graphic abstract is available for this article. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Early Cessation of Adenosine Diphosphate Receptor Inhibitors Among Acute Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention

Author

Fosbøl, Emil L., primary, Ju, Christine, additional, Anstrom, Kevin J., additional, Zettler, Marjorie E., additional, Messenger, John C., additional, Waksman, Ron, additional, Effron, Mark B., additional, Baker, Brian A., additional, Cohen, David J., additional, Peterson, Eric D., additional, and Wang, Tracy Y., additional

Published
2016
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9. Temporal Trends in the Risk Profile of Patients Undergoing Outpatient Percutaneous Coronary Intervention

Author

Vora, Amit N., primary, Dai, Dadi, additional, Gurm, Hitinder, additional, Amin, Amit P., additional, Messenger, John C., additional, Mahmud, Ehtisham, additional, Mauri, Laura, additional, Wang, Tracy Y., additional, Roe, Matthew T., additional, Curtis, Jeptha, additional, Patel, Manesh R., additional, Dauerman, Harold L., additional, Peterson, Eric D., additional, and Rao, Sunil V., additional

Published
2016
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10. Three-Year Outcomes Associated With Embolic Protection in Saphenous Vein Graft Intervention

Author

Brennan, J. Matthew, primary, Al-Hejily, Wesam, additional, Dai, David, additional, Shaw, Richard E., additional, Trilesskaya, Marina, additional, Rao, Sunil V., additional, Brilakis, Emmanouil S., additional, Anstrom, Kevin J., additional, Messenger, John C., additional, Peterson, Eric D., additional, Douglas, Pamela S., additional, and Sketch, Michael H., additional

Published
2015
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