1. Differences Between Patients With Intermittent Claudication and Critical Limb Ischemia Undergoing Endovascular Intervention: Insights From the Excellence in Peripheral Artery Disease Registry
- Author
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Avantika Banerjee, Ishita Tejani, Nicole Minniefield, Yulun Liu, Mohamad Amer Alaiti, Mitul Patel, Christopher Metzger, Chirag Patel, Peter Monteleone, Subhash Banerjee, Kunal Patel, Emmanouil S. Brilakis, Farshid Etaee, and Mehdi H. Shishehbor
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Disease ,Amputation, Surgical ,Peripheral Arterial Disease ,Disease registry ,Ischemia ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Humans ,Medicine ,Registries ,business.industry ,Vascular disease ,Endovascular Procedures ,Stent ,Critical limb ischemia ,Intermittent Claudication ,Limb Salvage ,medicine.disease ,Intermittent claudication ,body regions ,Treatment Outcome ,Amputation ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: There are limited data on differences in angiographic distribution of peripheral artery disease and endovascular revascularization strategies in patients presenting with intermittent claudication (IC) and critical limb ischemia (CLI). We aimed to compare anatomic features, treatment strategies, and clinical outcomes between patients with IC and CLI undergoing endovascular revascularization. Methods: We examined 3326 patients enrolled in the Excellence in Peripheral Artery Disease registry from 2006 to 2019 who were referred for endovascular intervention for IC (n=1983) or CLI (n=1343). The primary outcome was 1-year major adverse limb events, which included death, repeat target limb revascularization, or target limb amputation. Results: Patients with CLI were older and more likely to have diabetes and chronic kidney disease and less likely to receive optimal medical therapy compared with IC. Patients with IC had higher femoropopliteal artery interventions (IC 87% versus CLI 65%; P P P P P P =0.014). Major adverse limb event rates for patients with IC and CLI were 16% and 26%, respectively ( P Conclusions: Patients with IC and CLI have significant anatomic, lesion, and treatment differences with significantly higher mortality and adverse limb outcomes in CLI. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01904851. Graphic Abstract: A graphic abstract is available for this article.
- Published
- 2021