1. [Gender-specific differences in the development of colorectal cancer in Lynch syndrome patients-A systematic review].
- Author
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Dohmen J, Sommer N, van Beekum K, Nattermann J, Engel C, Kalff JC, Hüneburg R, and Vilz TO
- Subjects
- Humans, Female, Male, Sex Factors, Risk Factors, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology, Colorectal Neoplasms genetics, Colorectal Neoplasms epidemiology
- Abstract
Background: Lynch syndrome (LS) is the most frequent hereditary tumor syndrome and is associated with an increased risk of colorectal cancer (CRC). While gene-specific and age-specific differences are considered in patient surveillance, gender-specific risks in the development of CRC have been reported in many studies but are not consistently documented., Objective: This systematic review aims to investigate gender-specific differences in CRC development among LS patients., Material and Methods: A systematic literature search following PRISMA 2020 guidelines was conducted in the PubMed, Ovid, The Cochrane Library and Web of Science databases. A total of 688 studies were screened, and 41 met the inclusion criteria., Results: Men have a higher risk of CRC and develop CRC earlier compared to women., Conclusion: These findings indicate gender-specific differences in the risk of CRC among LS patients, although they do not currently justify separate surveillance strategies., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
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