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Your search keyword '"Zheng, Jia-Xin"' showing total 2 results
Start Over Author "Zheng, Jia-Xin" Journal chirality
2 results on '"Zheng, Jia-Xin"'

2. Application of kinetic resolution using HCS as chiral auxiliary: novel synthesis of beta-blockers (S)-betaxolol and (S)-metoprolol.

Author

Zhang JY, Liu HM, Wang XJ, Wang P, and Zheng JX

Subjects
Adrenergic beta-Antagonists chemistry, Betaxolol chemistry, Kinetics, Metoprolol chemistry, Molecular Structure, Stereoisomerism, Adrenergic beta-Antagonists chemical synthesis, Betaxolol chemical synthesis, Metoprolol chemical synthesis
Abstract

Optically pure (S)-betaxolol and (S)-metoprolol were prepared with an extremely facile and practical method using kinetic resolution of beta-amino alcohols employing HCS as chiral auxiliary. High enantiomeric purity (ee > 99%) was achieved and the synthetic strategy is amenable to industrial scale-up., (Copyright 2008 Wiley-Liss, Inc.)

Published
2009
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