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Objective: To explore the changing trajectory of psychological distress in young and middle-aged patients during peridialysis period. Methods: Totally 122 patients in the peridialysis period were investigated with the Self-Designed General Data Questionnaire, Distress Screening Scale（DSS）,Connor-Davidson Resilience Scale（CD-RISC）,Social Support Revalued Scale（SSRS） and Self-Perceived Burden Scale（SPBS） at the time of diagnosis, initial dialysis, and dialysis for 1 month,2 months and 3 months, respectively. The growth mix model was used to identify trajectory categories. Results: The time main effect of scores of DSS, CD-RISC and SPBS in peridialysis patients was statistically significant（Ps ＜0.05）,the scores of DSS and SPBS were the highest at the initial dialysis and the lowest at 3 months of dialysis. The CD-RISC scores were the lowest at the first dialysis and the highest at 3 months of dialysis. The trajectory of psychological distress was divided into 3 types, namely continuous high level（26.20%）,high level decline（40.72%）,and medium-low level decline（33.08%）.Conclusion: The psychological distress of young and middle-aged peridialysis patients shows different trajectories from diagnosis to regular dialysis. Clinical staff should pay more attention to the psychological status of the first-time dialysis patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the efficiency of Quick Cognitive Screening Scale for Elderly ( QCSS-E) in screening mild cognitive impairment (MCI) and mild-moderate dementia with Alzheimer Disease ( AD) from the elderly in community. Methods: A total of 1298 elderly aged 55 years or more were recruited from a community and divided into normal control (NC) group (n = 629), MCI group (n =573) and mild-moderate AD group (n -96) according to the Peterson MCI diagnostic criteria and DSM-5 neuroeognitive impairment AD diagnostic criteria as the gold standard. According to the gold standard, the positive predictive value and negative predictive value of MCI and AD were calculated. ROC curve was used to analyze the differentiation of the total score of the scale. Results: The positive predictive value of MCI and the negative predictive value were 67.6% and 83.9% respectively. The positive predictive value of AD screening was 64. 2% and the negative predictive value was 96. 9%. ROC curve analysis found that the AUC of QCSS-E total score screening for normal and MCI, normal and mild-moderate AD, MCI and mild-moderate AD were 83. 5%, 98. 0% and 85. 6% , respectively. Conclusion: The QCSS-E total score and each dimension score perform well in early AD screening, among which visual space, verbal fluency, abstract ability and delayed memory are the sensitive indicators for early AD recognition. [ABSTRACT FROM AUTHOR]