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2. Effects of shenmai injection on expression of TNF-alpha mRNA in peritoneal macrophages of scald mice.

Author

Wang R, Gao C, and Liu D

Subjects
Animals, Burns mortality, Gene Expression Regulation drug effects, Macrophages, Peritoneal cytology, Macrophages, Peritoneal metabolism, Mice, Mice, Inbred BALB C, RNA, Messenger genetics, RNA, Messenger metabolism, Survival Rate, Time Factors, Burns genetics, Drugs, Chinese Herbal pharmacology, Macrophages, Peritoneal drug effects, RNA, Messenger drug effects, Tumor Necrosis Factor-alpha genetics
Abstract

Objective: To explore the effect of shenmai injection (SI) on expression of TNF-alpha mRNA in peritoneal macrophages (pMPhis) of scald mice., Methods: BALB/c mice were inflicted with 11% of body surface area III degree scald and injected intraperitoneally (ip) with SI daily for 5 days, and expression of TNF-alpha mRNA in pMPhis was determined by semi-quantitative RT-PCR., Results: In scald mice, the expression of TNF-alpha mRNA in pMPhis increased significantly, but it was reduced obviously (P < 0.01) after SI administration, while the livability was increased markedly (P < 0.05)., Conclusions: For scald mice, the cause of death at early stage might be related to the high expression of TNF-alpha mRNA in pMPhis and the use of SI can decrease the death rate.

Published
2002

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