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Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of PRP combined with h UC-MSCs transplantation on the healing of osteoporotic fracture in rats. Methods Fifty female SPF grade SD rats were randomly divided into 5 groups, 10 rats in each group: The sham operation group was only resected ovarian tissues; The placebo group was injected with saline; The non-induction group transplanted withuninducedhUC-MSCs; The PRP + induction group transplanted withh UC-MSCs combined with PRP. After the OPF model was successfully constructed, cells were transplanted 3 times in each group,1 week, 3 weeks and 7 weeks after fracture. Micro-CT analysis was performed every two weeks after fracture. Results Micro-CT analysis results showed that the amount of callus formation in PRP + induction group was significantly increased than that in the other groups. Clinicalhealing criteria was achieved at 11 weeks post-fracture, while other groups callus remodeling phase is lagging behind. The bone healing time in rats was delayed for at least 37.5% compared with normal fracture animals. Conclusion PRP combined with h UC-MSCs transplantation promote osteoporotic fracture healing in rats. [ABSTRACT FROM AUTHOR]