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Objective To evaluate the short-term efficacy of Jintiange capsules( JTG) and to observe its effect on bone turnover markers. Methods Forty-four volunteers were recruited in JTG efficacy study from our hospital. They were divided into bone mineral density( BMD) abnormal group and normal control group,according to the measurement results using dual energy X-ray absorptiometry( DEXA). They all received JTG for 1 month. Biochemical indexes of bone turnover,including procollagen type I intact N-terminal propeptide( PINP) and β-C-terminal telopeptides of type 1 collagen( β-CTX),were measured before and after the treatment. After the treatment,the short-term efficacy was evaluated using visual analogue score( VAS). The changes of PINP and β-CTX between two groups before and after the treatment were compared using Student ’s t test. Results After JTG treatment,the symptoms of pain or discomfort in muscles were significantly alleviated. PINP and β-CTX in BMD normal group showed no significant difference comparing with that before the treatment. In BMD abnormal group,PINP increased and β-CTX decreased slightly. Conclusion JTG has dual-directional regulation function. It promotes the activity of osteoblasts,inhibits the activity of osteoclasts,and maintains the dynamic balance of bone formation and bone resorption. [ABSTRACT FROM AUTHOR]