1. 术前单核细胞淋巴细胞比值对食管胃 结合部癌患者术后生存的影响.
- Author
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周文杰, 吴骏, 李晓东, 王琦, 倪雪峰, 蒋敬庭, 季枚, and 吴昌平
- Abstract
Objective To investigate the associations between various blood test parameters including MLR (monocyte-lymphocyte ratio) and prognosis in post-operative esophagogastric junction cancer patients. Methods We retrospectively studied the preoperative and postoperative data of 309 patients who underwent radical surgery for esophagogastric junction cancer. The relationship between MLR, neutrophil lymphocyte ratio (NLR), platelet⁃lymphocyte ratio (PLR) and overall survival (OS) was analyzed. Results The cutoff values of MLR、NLR and PLR were 0.201, 1.697 and 96.960, respectively. The median OS was 51.4 months for all the patients in the study group (n =309). MLR in patients with esophagogastric junction carcinoma was associated with gender, depth of invasion, histological grade, TNM stage, NLR and PLR (P<0.05). PLR was associated with tumor size, TNM stage, NLR and MLR ( P < 0. 05). NLR was associated with gender, tumor size, TNM stage, PLR and MLR (both P<0.05). Univariate analysis showed that tumor size, depth of tumor invasion, metastasis of lymph nodes, pathological grading, nerve infiltration, lymphovascular invasion, TNM staging, PLR and MLR were associated with the median overall survival time (P< 0.05). Multivariate analysis showed that TNM stage,nerve infiltration and MLR were independent prognostic predictors for patients with esophagogastric junction cancer (P <0.05), but not PLR or NLR. Setting the optimal cut⁃off value of the MLR in 0.201, the area under the curve was 0.603, significantly larger than that of PLR and NLR (P<0.05). Conclusions Preoperative MLR is a very useful predictor of patients with esophagogastric junction cancer who underwent radical rescetion. Preoperative MLR> 0.201 is an independent risk factor for postoperative survival in patients with esophagogastric cancer, and PLR> 96.960 may predict a poor prognosis risk. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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