1. Protective effect of capsaicin against methyl methanesulphonate induced toxicity in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg 9 .
- Author
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Khanam S, Fatima A, Jyoti RS, Ali F, Naz F, Shakya B, and Siddique YH
- Subjects
- Acetylcholinesterase metabolism, Animals, Animals, Genetically Modified, DNA Damage drug effects, Larva drug effects, Anticarcinogenic Agents pharmacology, Capsaicin pharmacology, Drosophila melanogaster drug effects, Methyl Methanesulfonate antagonists & inhibitors
- Abstract
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the main component in hot peppers, including red chili peppers, jalapenos, and habanero, belonging to the genus Capsicum. Capsaicin is a potent antioxidant that interferes with free radical activities. In the present study, the possible protective effect of capsaicin was studied against methyl methanesulphonate (MMS) induced toxicity in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg
9 . The third instar was allowed to feed on the diet having different doses of capsaicin and MMS separately and in combination. The results suggested that the exposure of third instar larvae to the diet having MMS alone showed significant hsp70 expression as well as tissue DNA and oxidative damage, whereas the larvae feed on the diet having MMS and capsaicin showed a decrease in the toxic effects for 48-h of exposure. In conclusion, capsaicin showed a dose-dependent decrease in the toxic effects induced by MMS in the third instar larvae of transgenic Drosophila melanogaster., (Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.)- Published
- 2017
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