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Comprehensive Summary: Deoxyribonucleic acid (DNA) is a biomacromolecule, as well as a polymeric material, whose sequences with different manipulative structures enable them to implement a series of functions, such as reorganization, target, and catalysis. Compared to existing traditional materials incapable of multifunctional integration, the polymeric DNA network is a form of material that can achieve functional integration while maintaining specific DNA properties. Furthermore, precise target enabled by DNA network is one of the most essential components of cellular manipulation. Hence, the DNA network is indispensable and irreplaceable to cell manipulation that it is a versatile tool for the understanding of basic laws of living life and treatments of diseases, such as cell isolation, cell delivery, and cell interference. Herein, the construction of polymeric DNA network is briefly introduced from the aspects of assembly modules, construction methods, and properties. Subsequently, the applications of DNA network in the field of cell manipulation, including cell isolation and encapsulation, intracellular inference and detection, and tumor therapy are summarized. Finally, we provide some prospects for further research and applications of DNA network for cell manipulation. [ABSTRACT FROM AUTHOR]