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Designing and synthesizing nanomedicines with multi-modal tumor therapeutic capabilities is the key to cancer treatment. Herein, we prepared MICG nanoparticles (NPs) by assembling glucose oxidase (GOx) and indocyanine green (ICG) with manganese carbonate (MnCO3) NPs for starvation therapy cascaded chemodynamic therapy, enhanced phototherapy and immune activation. In MICG NPs, the GOx consumes intratumoral glucose resulting in starvation therapy, and simultaneously produces H2O2and decreases pH in tumor. The intensified acidic tumor environment promotes the decomposition of MnCO3NPs to release Mn2+. The Mn2+further catalyzes H2O2to generate hydroxyl radical for chemodynamic therapy. While ICG can generate singlet oxygen (1O2) and heat to kill cancer cells through phototherapy mechanism. The hydroxyl radical and 1O2will further accelerate the oxidative stress, intensify immunogenic cell death, induce dendritic cell maturation, and thus activate systemic immunity. This work provides a new therapeutic platform for combining therapy of tumor.

Benzoyl peroxide (BPO) has been added in wheat flour because of its bleaching effect. However, the abnormal used BPO has caused increasing concern due to its strong oxidization capability which may have adverse effects on living organisms. Herein, we present a carbon dot (CD)-based fluorescent and colorimetric probe for visually, sensitively and selectively sensing BPO. The addition of BPO could quench the red fluorescence of CDs peaked at 622 and 677 nm, and decrease the absorbance at 613 nm, while increase the absorbance at 450 nm, resulting in a fluorescence turn-off and colorimetric spectral response. Moreover, the CDs had short response time of 10 min and high sensitivity towards BPO with a low limit of detection of 28 nmol/L. The applicability of the CDs in detecting BPO in wheat, noodle and starch samples was further demonstrated, and good recovery results were obtained.