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Promoting chronic wound healing has always been a hot topic in the field of biomaterials due to its heavy burden on both patients’ quality of life and healthcare systems. MXene is a type of two-dimensional (2D) nanomaterial with a unique physical structure and surface chemical properties. The remarkable antibacterial capacity, fast photothermal response ability and electrical conductivity of MXene, indicate that MXene-based hydrogels possess considerable potential for promoting chronic wound healing. In this review, we summarize the preparation and properties of MXene, and mainly focus on the applications of MXene-based hydrogels in chronic wound healing. The purpose of this review is to provide a reference for further study and promote the application of MXene-based hydrogels in clinical practice in the future.

Nowadays, there are still many challenges to skin regeneration. As a new type of skin substitute, hydrogel has emerging gradually with its excellent properties. However, it is still a challenge to combine with biological active agents to facilitate skin regeneration. Under the circumstance, we synthesized arginine-based poly (ester amide) (Arg-PEA) and hyaluronic acid (HA-MA), and combined them into new hybrid hydrogels via photo-crosslinking. We found that the internal structure and physicochemical properties of hybrid hydrogels were greatly improved with the increase of content of Arg-PEA. Therefore, we designed hybrid hydrogels with 5 wt% and 10 wt% of Arg-PEA content, respectively. Besides, we selected the corresponding anti-inflammatory (CRP, TNF-α) indicators to detect the anti-inflammatory properties of the hybrid hydrogels at the protein level, and the corresponding antioxidant indicators (SOD, GSH/GSSG, MDA) were selected to investigate the antioxidant properties of hybrid hydrogels at the cellular level in vitro. In addition, we also selected relevant genes to test the effect of hybrid hydrogels on fibrosis and vascularization in the process of skin wound healing in vitro and verified them in vivo with a mouse dorsum wound model. The results confirmed that Arg-PEA/HA-MA (AH) hybrid hydrogel was a prospective scaffold material for skin regeneration.