1. Total synthesis of cyclic heptapeptide euryjanicin B
- Author
-
Chunmei Zhang, Jun Xiang Guo, Liang Wang, Xiao Yun Chai, Qiu Ye Wu, and Honggang Hu
- Subjects
Euryjanicin B ,chemistry.chemical_classification ,Solid-phase synthesis ,General method ,Stereochemistry ,Chemistry ,Fmoc chemistry ,Total synthesis ,General Chemistry ,Solution synthesis ,Combinatorial chemistry ,Cyclic peptide ,Amino acid - Abstract
The first synthesis of the naturally occurring cyclic peptide euryjanicin B has been achieved. A general method was described to synthesize the cyclic peptide by a two-step solid-phase/solution synthesis strategy. All the amino acids in this study are L -configuration, The linear heptapeptide was assembled by standard Fmoc chemistry on solid-phase and subsequently cyclization was carried out by solution method.
- Published
- 2011