1. A new facile synthesis of shikalkin
- Author
-
Jun Chao Cai, Hao Lun Tang, Yan Qiang Shao, and Qun Lu
- Subjects
chemistry.chemical_compound ,Chemistry ,Stereochemistry ,Yield (chemistry) ,Grignard reaction ,General Chemistry ,Combinatorial chemistry - Abstract
A short and convergent approach for the synthesis of shikalkin (dl-shikonin) is presented. Stobbe reaction was employed to construct the aromatic skeleton 6. This is followed by a practical method to prepare the key epoxides 9 from aldehydes 8 in high yield. Finally, shikalkin is achieved by Grignard reaction and oxidation.
- Published
- 2008
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