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Despite the generous legislative environments that protects children from sexual abuse, the magnitude of child sexual abuse has not changed much in most societies across the globe, especially in Africa. This has been attributed to the limited studies on the subject due to its sensitive and complex nature. Where studies are done, researchers have had to negotiate carefully through the matrix of gaining access and consent, through to ensuring that victims are not further victimized in the process of research. This paper discusses some practical and ethical challenges inherent in researching the phenomenon of child sexual abuse in Ghana. The paper outlines and discusses the undergirding principles and strategies for conducting child-sensitive research to serve as a framework for researches who want to conduct studies on child sexual abuse and other sensitive topics in Africa. [ABSTRACT FROM AUTHOR]