1. Podoplanin-Positive Cancer-Associated Fibroblasts Could Have Prognostic Value Independent of Cancer Cell Phenotype in Stage I Lung Squamous Cell Carcinoma
- Author
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Norihiko Ikeda, Tomoyuki Hishida, Teruhisa Takuwa, Satoshi Fujii, Shotaro Ono, Junji Yoshida, Kanji Nagai, Atsushi Ochiai, Genichiro Ishii, Keiju Aokage, and Mitsuyo Nishimura
- Subjects
Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,Tumor microenvironment ,biology ,Cadherin ,business.industry ,CD44 ,Critical Care and Intensive Care Medicine ,medicine.disease ,Phenotype ,Podoplanin ,Internal medicine ,Cancer cell ,medicine ,biology.protein ,Cancer-Associated Fibroblasts ,Cardiology and Cardiovascular Medicine ,Lung cancer ,business - Abstract
Background The prognostic significance of the tumor microenvironment, which is created by both cancer cells and cancer-associated fibroblasts (CAFs), has been increasingly recognized. The purpose of this study was to analyze the prognostic markers of stage I squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both cancer cells and CAFs. Methods A total of 142 patients with stage I SqCC were included in this study. We examined the expressions of E-cadherin, laminin-5, podoplanin, c-MET, carbonic anhydrase IX (CA-IX), CD10, and CD44 in the cancer cells and those of podoplanin, CA-IX, CD10, and CD44 in the CAFs to evaluate their prognostic value. Results Patients with low E-cadherin expression in the cancer cells showed a significantly poorer prognosis than those with high E-cadherin expression in the cancer cells ( P P P = .013 and P = .0011, respectively). According to subgroup analyses combining E-cadherin expression in cancer cells and podoplanin expression in CAFs, 5-year overall survival of patients with low E-cadherin expression in the cancer cells and high podoplanin expression in the CAFs was 7.0% and showed a significantly poorer prognosis as compared with other groups ( P Conclusions The current study indicates that immunophenotypes of CAFs could have a prognostic value independent of those of the cancer cells in SqCC.
- Published
- 2013