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1. Achieving Molecular Profiling in Pleural Biopsies

Author

Anand Sundaralingam, Avinash Aujayeb, Baki Akca, Clare Tiedeman, Vineeth George, Michael Carling, Jennifer Brown, Radhika Banka, Dinesh Addala, Eihab O. Bedawi, Rob J. Hallifax, Beenish Iqbal, Poppy Denniston, Maria T. Tsakok, Nikolaos I. Kanellakis, Florian Vafai-Tabrizi, Michael Bergman, Georg-Christian Funk, Rachel E. Benamore, John M. Wrightson, and Najib M. Rahman

Subjects
Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Published
2023
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2. Achieving Molecular Profiling in Pleural Biopsies: A Multicenter, Retrospective Cohort Study

Author

Anand, Sundaralingam, Avinash, Aujayeb, Baki, Akca, Clare, Tiedeman, Vineeth, George, Michael, Carling, Jennifer, Brown, Radhika, Banka, Dinesh, Addala, Eihab O, Bedawi, Rob J, Hallifax, Beenish, Iqbal, Poppy, Denniston, Maria T, Tsakok, Nikolaos I, Kanellakis, Florian, Vafai-Tabrizi, Michael, Bergman, Georg-Christian, Funk, Rachel E, Benamore, John M, Wrightson, and Najib M, Rahman

Abstract

Pleural biopsy findings offer greater diagnostic sensitivity in malignant pleural effusions compared with pleural fluid. The adequacy of pleural biopsy techniques in achieving molecular marker status has not been studied, and such information (termed "actionable" histology) is critical in providing a rational, efficient, and evidence-based approach to diagnostic investigation.What is the adequacy of various pleural biopsy techniques at providing adequate molecular diagnostic information to guide treatment in malignant pleural effusions?This study analyzed anonymized data on 183 patients from four sites across three countries in whom pleural biopsy results had confirmed a malignant diagnosis and molecular profiling was relevant for the diagnosed cancer type. The primary outcome measure was adequacy of pleural biopsy for achieving molecular marker status. Secondary outcomes included clinical factors predictive of achieving a molecular diagnosis.The median age of patients was 71 years (interquartile range, 63-78 years), with 92 of 183 (50%) male. Of the 183 procedures, 105 (57%) were local anesthetic thoracoscopies (LAT), 12 (7%) were CT scan guided, and 66 (36%) were ultrasound guided. Successful molecular marker analysis was associated with mode of biopsy, with LAT having the highst yield and ultrasound-guided biopsy the lowest (LAT vs CT scan guided vs ultrasound guided: LAT yield, 95%; CT scan guided, 86%; and ultrasound guided, 77% [P = .004]). Biopsy technique and size of biopsy sample were independently associated with successful molecular marker analysis. LAT had an adjusted OR for successful diagnosis of 30.16 (95% CI, 3.15-288.56; P = .003) and biopsy sample size an OR of 1.18 (95% CI, 1.02-1.37) per millimeter increase in tissue sample size (P .03).Although previous studies have shown comparable overall diagnostic yields, in the modern era of targeted therapies, this study found that LAT offers far superior results to image-guided techniques at achieving molecular profiling and remains the optimal diagnostic tool.

Published
2022

3. AN UNUSUAL CASE OF DISSEMINATED CRYPTOCOCCOSIS

Author

Kabu Chawla, Michael Bergman, William Pascal, Sakthidev Kulandaisamy, Arjun Saradna, Shyam Shankar, Prarthna Chandar, and Anna Abbasi

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Unusual case, Disseminated cryptococcosis, business.industry, Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business, Dermatology
Published
2018
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6. BLADDER OUTLET OBSTRUCTION LEADING TO URINOTHORAX

Author

Michael Bergman, Ryan Richard, and Jigna Solanki

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Bladder outlet obstruction, Urinothorax, business.industry, Urology, Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business
Published
2018
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7. A Rare Case of Thymic Rebound Hyperplasia

Author

Kabu Chawla, Sakthidev Kulandaisamy, Michael Bergman, Benhoor Shamian, Pavan Irukulla, Shyam Shankar, Prarthna Chandar, Yizhak Kupfer, and Mangalore Amith Shenoy

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, business.industry, Hyperplasia, Critical Care and Intensive Care Medicine, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Rare case, Medicine, Cardiology and Cardiovascular Medicine, business
Published
2017
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8. Coccidioides Mycetoma? A Rare Cause of Hemoptysis

Author

Michael Bergman and Ryan Richard

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, biology, business.industry, Medicine, Coccidioides, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, Mycetoma, biology.organism_classification, business, Dermatology
Published
2017
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9. Plasma Exchange and Cyclophosphamide in Combination as Rescue Therapy for Severe Granulomatosis With Polyangiitis Refractory to Rituximab Therapy

Author

Michael Bergman and Galina Lyles

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Cyclophosphamide, business.industry, Critical Care and Intensive Care Medicine, medicine.disease, Gastroenterology, Refractory, Rescue therapy, Rituximab therapy, Internal medicine, medicine, Cardiology and Cardiovascular Medicine, business, Granulomatosis with polyangiitis, medicine.drug
Published
2017
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10. Restrictive EGFR Mutation

Author

Michael Bergman, Alfred Astua, and Lina Miyakawa

Subjects
Pulmonary and Respiratory Medicine, business.industry, Egfr mutation, Mutation (genetic algorithm), Cancer research, Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business
Published
2016
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11. The Mistaken Sentinel: Atypical Aspergillus-Associated Hemoptysis

Author

Michael Bergman, Samuel Acquah, Becky Lou, Benjamin Verplanke, and Angela Love

Subjects
Pulmonary and Respiratory Medicine, Aspergillus, medicine.medical_specialty, biology, business.industry, Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business, biology.organism_classification, Dermatology
Published
2016
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12. An Interesting Case of Persistent Pyrexia With Eosinophilia and Pulmonary Infiltrates: 'Popcorn Aspiration'

Author

Karishma Kitchloo, Animesh Gour, Michael Bergman, Shyam Shankar, Pavan Gorukanti, Mangalore Amith Shenoy, Omar Taha, Suchit Khanijao, and William Pascal

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, business.industry, Critical Care and Intensive Care Medicine, medicine.disease, Pulmonary aspiration, medicine, Eosinophilia, Pulmonary infiltrates, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Lung infiltration
Published
2016
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13. Diffusing Lung Capacity Reveals Phenotypical Complexity in Pulmonary Hypertension

Author

David Nesheim, Albert Miller, Jason Filopei, Roxana Sulica, Michael Lau, Michael Bergman, Navitha Ramesh, and Sarun Thomas

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung, business.industry, Critical Care and Intensive Care Medicine, medicine.disease, Pulmonary hypertension, Phenotype, medicine.anatomical_structure, Internal medicine, Cardiology, Medicine, Lung volumes, Cardiology and Cardiovascular Medicine, business
Published
2015
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14. MALT Lymphoma of the Trachea

Author

Michael Bergman, Daniel Fein, Samuel Acquah, Navitha Ramesh, Jason Filopei, and Sarun Thomas

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, business.industry, medicine, MALT lymphoma, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, medicine.disease, business
Published
2015
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15. Progressive Shortness of Breath, Sudden Blindness, and Hypoxemia

Author

Sarun Thomas, Navitha Ramesh, Albert Miller, Jason Filopei, and Michael Bergman

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Internal medicine, Sudden blindness, medicine, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business, Hypoxemia
Published
2015
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16. Refractory Shock in a Diabetic - Toxic Situation With an Antidote

Author

Navitha Ramesh, Michael Bergman, Sarun Thomas, and Jason Filopei

Subjects
Pulmonary and Respiratory Medicine, business.industry, Diabetes mellitus, medicine.medical_treatment, medicine, Pharmacology, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, medicine.disease, business, Refractory shock, Antidote
Published
2015
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17. Strongyloides Diffuse Alveolar Hemorrhage in AIDS

Author

Samuel Acquah, Navitha Ramesh, Michael Bergman, Sarun Thomas, David Nesheim, and Jason Filopei

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, biology, business.industry, Diffuse alveolar hemorrhage, Critical Care and Intensive Care Medicine, biology.organism_classification, medicine.disease, Acquired immunodeficiency syndrome (AIDS), Strongyloides, medicine, Cardiology and Cardiovascular Medicine, business
Published
2015
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18. Shortness of Breath in a Young Woman: Is One Lung Enough?

Author

Alfred Astua, Michael Bergman, Sarun Thomas, Jason Filopei, and Navitha Ramesh

Subjects
Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Lung, medicine.anatomical_structure, business.industry, medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business
Published
2015
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19. B-Cell Lymphoma in Association With Organizing Pneumonia

Author

Vishesh Paul, Jay Lipshitz, and Michael Bergman

Subjects
Pulmonary and Respiratory Medicine, business.industry, Association (object-oriented programming), Immunology, medicine, Organizing pneumonia, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, B-cell lymphoma, medicine.disease, business
Published
2014
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20. A Rare Etiology of Calcified Pleural Plaques

Author

Guy Aristide, Joseph Gorga, and Michael Bergman

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, business.industry, medicine, Etiology, Pleural plaque, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, medicine.disease, business
Published
2012
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21. RESPIRATORY THERAPIST-DRIVEN RAPID EXTUBATION PROTOCOL

Author

Joshua D. Rosenberg, Pete Smith, Miwa Fujiwara, Michael Bergman, Barbara Maffia, and Rodel Rogando

Subjects
Pulmonary and Respiratory Medicine, Protocol (science), medicine.medical_specialty, business.industry, medicine.medical_treatment, Respiratory therapist, Physical therapy, Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business
Published
2008
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22. INITIATING AN INPATIENT SMOKING CESSATION PROGRAM

Author

Michael Bergman, Latoya Fyffe, Pete Smith, Kathy A. Garrett-Szymanski, Rosemarie Samuels, and Jeanne McCabe

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, medicine.medical_treatment, Emergency medicine, Medicine, Smoking cessation, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business
Published
2005
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23. POSTOPERATIVE PULMONARY COMPLICATIONS AFTER ABDOMINAL SURGERY

Author

Michael Bergman, Pete Smith, Muhammed Baig, Fayez Bader, Siddarth Shah, Jason Akulian, Veronica Brito, and Antonio Alfonso

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business, Abdominal surgery, Surgery
Published
2005
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