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2. Considerations in Optimizing Radiation Therapy for Non-small Cell Lung Cancer

Author

James R. Jett, S. Bahri, Joel S. Greenberger, Chandra P. Belani, Michael W. Epperly, and A.M. Kalend

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Pathology, Lung Neoplasms, Genetic enhancement, medicine.medical_treatment, Transgene, Critical Care and Intensive Care Medicine, Mice, Therapeutic index, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Animals, Humans, Lung cancer, Radiation treatment planning, Lung, Neoplasm Staging, Clinical Trials as Topic, Radiotherapy, business.industry, Respiratory disease, Radiotherapy Dosage, Genetic Therapy, medicine.disease, Radiation therapy, Treatment Outcome, Dose Fractionation, Radiation, Radiation protection, Cardiology and Cardiovascular Medicine, business
Abstract

Irradiation therapy for lung cancer is mostly restricted to conventional methods. To improve therapeutic ratio, we have combined a treatment planning and a gene therapy approach. Three-dimensional conformal radiotherapy is described as carried out by methods of gene therapy for radiation protection using the manganese-superoxide-dismutase transgene delivered by inhalation gene transfer. These methods may improve therapeutic outcomes in lung cancer.

Published
1998
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