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2 results on '"COVID-19, coronavirus disease"'

1. HISTOLOGICAL FINDINGS IN TRANSBRONCHIAL CRYOBIOPSIES OBTAINED FROM PATIENTS AFTER COVID-19

Author

Mario Culebras, Karina Loor, Irene Sansano, Óscar Persiva, David Clofent, Eva Polverino, Almudena Felipe, Jeisson Osorio, Xavier Muñoz, Antonio Álvarez, Jordi Andreu, Marta Arjona, Cristina Berastegui, Miriam Barrecheguren, José Cardoso, Ma Jesús Cruz, Ma Luiza De Souza, David Espejo, Galo Granados, Ma Ángeles Jiménez, Manuel López, Íñigo Ojanguren, Mercedes Pallero, Ma Antonia Ramon, Santiago Ramon y Cajal, Eva Ma Revilla, Christian Romero, Berta Sáez, Júlia Sampol, Eduardo Vélez, and Ana Villar

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, 2019-20 coronavirus outbreak, medicine.medical_specialty, DLCO, diffusion capacity of the lung for carbon monoxide, CT, computerized tomography, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Biopsy, MEDLINE, PF, pulmonary fibrosis, Critical Care and Intensive Care Medicine, Cryosurgery, Internal medicine, Bronchoscopy, Research Letter, Medicine, Humans, SARS, severe acute respiratory syndrome, Lung, Pandemics, COVID-19, coronavirus disease, Aged, TBC, transbronchial cryobiopsy, business.industry, SARS-CoV-2, COVID-19, Middle Aged, OP, organizing pneumonia, FB, flexible bronchoscope, Spain, DILD, diffuse interstitial lung disease, Female, Radiology, Cardiology and Cardiovascular Medicine, business
Published
2021

2. It Takes a Village…: Contending With Drug Shortages During Disasters

Author

Lisa D, Burry, Jeffrey F, Barletta, David, Williamson, Salmaan, Kanji, Ryan C, Maves, Jeffrey, Dichter, Michael D, Christian, James, Geiling, and Brian L, Erstad

Subjects
Internationality, Critical Care, Drug Industry, WHO, World Health Organization WHO, Strategic Stockpile, Antiviral Agents, Lopinavir, Article, Disasters, ICU, Intensive Care Unit, Humans, Hypnotics and Sedatives, IPF, International Pharmaceutical Federation, PPE, Personal protective equipment, LMIC, low- and middle-income countries, COVID-19, coronavirus disease, Inventories, Hospital, Ritonavir, United States Food and Drug Administration, Drug Repositioning, Surge Capacity, COVID-19, Length of Stay, Respiration, Artificial, FDA, Food and Drug Administration, United States, Drug Combinations, GMP, Good Manufacturing Practice, Pharmaceutical Preparations, NME, new molecular entities, Hydroxychloroquine
Abstract

Critical drug shortages have been widely documented during the coronavirus disease 2019 (COVID-19) pandemic, particularly for IV sedatives used to facilitate mechanical ventilation. Surges in volume of patients requiring mechanical ventilation coupled with prolonged ventilator days and the high sedative dosing requirements observed quickly led to the depletion of "just-in-time" inventories typically maintained by institutions. This manuscript describes drug shortages in the context of global, manufacturing, regional and institutional perspectives in times of a worldwide crisis such as a pandemic. We describe etiologic factors that lead to drug shortages including issues related to supply (eg, manufacturing difficulties, supply chain breakdowns) and variables that influence demand (eg, volatile prescribing practices, anecdotal or low-level data, hoarding). In addition, we describe methods to mitigate drug shortages as well as conservation strategies for sedatives, analgesics and neuromuscular blockers that could readily be applied at the bedside. The COVID-19 pandemic has accentuated the need for a coordinated, multi-pronged approach to optimize medication availability as individual or unilateral efforts are unlikely to be successful.

Published
2020

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