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In patients with hemodynamic instability, neurological changes, cardiopulmonary compromise, or end organ damage, hyperbaric oxygen therapy (HBOT) is the recommended definitive therapy to reduce air bubble size and vascular obstruction. In this case, swift action using bedside cardiac ultrasound and intra-cardiac aspiration by a single orifice CVC lead to rapid clinical improvement. Bedside ultrasonography and manual intra-cardiac aspiration has the potential to efficiently and effectively improve patient outcomes. [Extracted from the article]