1. Voxelotor as a Treatment of Persistent Hypoxia in the ICU.
- Author
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Al-Qudsi, Omar, Reynolds, John M., Haney, John C., and Welsby, Ian J.
- Subjects
- *
SICKLE cell anemia , *HYPOXEMIA , *HEMOGLOBINS , *EXTRACORPOREAL membrane oxygenation - Abstract
Hypoxia is encountered frequently in the ICU as a result of a wide range of pathologic characteristics. The oxygen-hemoglobin dissociation curve describes hemoglobin's affinity for a given P o 2 and factors affecting uptake and offload. Research in manipulating this relationship between hemoglobin and oxygen is sparing. Voxelotor is a hemoglobin oxygen-affinity modulator that is approved by the US Food and Drug Association for use in the management of sickle cell disease. We present two patients without sickle cell disease who underwent treatment with this novel agent to assist with chronic hypoxia and weaning of mechanical support. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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