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1. Contents Vol. 56, 2010

Author

Tun-Chieh Chen, Zi-ming Li, Zheng-bo Song, Run-bo Zhong, D.A. Spandidos, Jeeyun Lee, Shun Lu, Junji Kita, Wan-Chin Chen, Xiao-Feng Sun, Gulseren Aktas, Toshihito Tsubosaka, Kohichi Yamauchi, Hong Zhang, S. Baritaki, Yasunao Kogashiwa, Aylin Şentürk, Silvia Park, Zhen-Long Zhu, Toshimasa Tsujinaka, Joon Oh Park, Maryam Pourpaki, Ho Yeong Lim, Yukinori Kurokawa, Jin Hyun Cho, A. Georgiladakis, Berna Ozbek, Takehiro Karaho, Yhu-Chering Hwang, Da-Wei Wang, Hong Jian, Bo Jin, Lidan Liu, Yong-feng Yu, Zhen Zhou, Ming-Wei Wang, Rocsanna Namdar, Druck Reinhardt Druck Basel, Aihua Tan, S. Maraki, Takehiro Matsuda, Young Suk Park, H. Messaritakis, Cun Liao, Mitsugi Shimoda, Hiroshi Nagafuji, Takeshi Maruyama, Se Hoon Park, Keiichi Kubota, Chih-Jung Chen, Motohiro Hirao, Satz Mengensatzproduktion, Yan-Hong Yang, Po-Liang Lu, Bao-hui Han, Kazumasa Fujitani, Zohreh Mohammadtaheri, Mohammad Reza Masjedi, Yi-fei Zhang, Tokihiko Sawada, G. Samonis, Yunfei Cao, Dong-Sheng Cui, Naoyuki Kohno, Masato Katoh, Zhi-wei Chen, Won Ki Kang, Feng Gao, Eiji Mita, Jann-Tay Wang, Shoichi Nakazuru, I.K. Neonakis, Shan-Chwen Chang, Hiroko Hasegawa, Itzhak Brook, Forouzan Mohammadi, Ai-mi Huang, Bao-Yong Yan, Sengul Derbentli, and Anjali N. Kunz

Subjects
Pharmacology, Infectious Diseases, Oncology, Drug Discovery, Pharmacology (medical), General Medicine
Published
2010
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2. Phase I study of S-1 plus nedaplatin in patients with advanced/recurrent head and neck cancer

Author

Toshihito Tsubosaka, Naoyuki Kohno, Kohichi Yamauchi, Yasunao Kogashiwa, Takeshi Maruyama, Takehiro Karaho, Hiroshi Nagafuji, and Takehiro Matsuda

Subjects
Oncology, Male, medicine.medical_specialty, Maximum Tolerated Dose, Organoplatinum Compounds, chemistry.chemical_compound, Internal medicine, Drug Discovery, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), In patient, Nedaplatin, Neoplasms, Squamous Cell, Aged, Tegafur, Pharmacology, Cisplatin, business.industry, Squamous Cell Carcinoma of Head and Neck, Head and neck cancer, Carcinoma, Induction chemotherapy, General Medicine, Middle Aged, medicine.disease, humanities, digestive system diseases, Surgery, Phase i study, Regimen, Drug Combinations, Oxonic Acid, Infectious Diseases, chemistry, Fluorouracil, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Disease Progression, Female, Neoplasm Recurrence, Local, business, medicine.drug
Abstract

Background: Cisplatin plus fluorouracil is widely used for the treatment of head and neck cancer. However, the cisplatin plus fluorouracil regimen necessitates hospitalization. Therefore, we planned to develop a new regimen that can be administered on an outpatient basis and performed a phase I study of S-1 + nedaplatin. Methods: S-1 was given orally at a fixed dose for 14 days, and nedaplatin was administered intravenously on day 8 of S-1 administration. The dose of nedaplatin was increased in 10-mg/m2 steps to find the maximum tolerated dose, depending on the appearance of dose-limiting toxicities. Results: A total of 14 patients were registered. The maximum tolerated dose of nedaplatin was determined to be 90 mg/m2. The main toxicities were neutropenia and thrombocytopenia. The response rate was 57.1%. Conclusion: The recommended dose of nedaplatin for a phase II study was determined to be 80 mg/m2. We concluded that our regimen was well tolerated and that the response rate was acceptable.

Published
2010

3. Subject Index Vol. 56, 2010

Author

Zheng-bo Song, Jeeyun Lee, Anjali N. Kunz, Gulseren Aktas, Zohreh Mohammadtaheri, S. Baritaki, Shan-Chwen Chang, Yukinori Kurokawa, Kohichi Yamauchi, Zhi-wei Chen, Yasunao Kogashiwa, Rocsanna Namdar, Druck Reinhardt Druck Basel, Aihua Tan, Sengul Derbentli, Zhen-Long Zhu, Run-bo Zhong, D.A. Spandidos, Toshimasa Tsujinaka, Yong-feng Yu, Wan-Chin Chen, Bo Jin, Da-Wei Wang, Mitsugi Shimoda, Zhen Zhou, Yunfei Cao, Ho Yeong Lim, Chih-Jung Chen, Forouzan Mohammadi, Ai-mi Huang, Naoyuki Kohno, Masato Katoh, Shun Lu, Mohammad Reza Masjedi, Bao-Yong Yan, Joon Oh Park, Maryam Pourpaki, Takehiro Matsuda, Yhu-Chering Hwang, Hiroko Hasegawa, Keiichi Kubota, A. Georgiladakis, Won Ki Kang, Feng Gao, Jann-Tay Wang, Hong Jian, Satz Mengensatzproduktion, Itzhak Brook, Takehiro Karaho, Tun-Chieh Chen, Zi-ming Li, Junji Kita, H. Messaritakis, Hong Zhang, Silvia Park, S. Maraki, Young Suk Park, Takeshi Maruyama, Yan-Hong Yang, Po-Liang Lu, Motohiro Hirao, Yi-fei Zhang, Dong-Sheng Cui, Ming-Wei Wang, Berna Ozbek, Xiao-Feng Sun, Aylin Şentürk, Jin Hyun Cho, Lidan Liu, G. Samonis, Toshihito Tsubosaka, Hiroshi Nagafuji, Se Hoon Park, Tokihiko Sawada, Shoichi Nakazuru, I.K. Neonakis, Eiji Mita, Bao-hui Han, Kazumasa Fujitani, and Cun Liao

Subjects
Pharmacology, Infectious Diseases, Index (economics), Oncology, Drug Discovery, Statistics, Pharmacology (medical), Subject (documents), General Medicine, Mathematics
Published
2010
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