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1. Contents Vol. 59, 2013

Author

Hideki Hayashi, Gloria Royo, Natividad López-Riquelme, Salomon M. Stemmer, Takashi Nishimura, Midori Ikeda, Ruth E Brown, Gali Perl, Pilar López, Antonio Galiana, Takashi Eto, Akitomi Shirato, Irit Ben-Aharon, Maria-Magdelana Balp, Noriyoshi Miura, Yuichi Sakamori, Iwao Fukui, Keisei Taku, Toshiyuki Iwata, Young Hak Kim, Arturo Soto-Matos, Hirotoshi Kikuchi, Chantelle Browne, Shinji Urakami, Kenichi Nishimura, Yuki Miyauchi, Mike Allen, Ryuichi Nakano, Mana Kamezato, Noemi Muszbek, Hiroki Nagai, Fotini Fligou, Pavel Novy, Takane Kikuchi-Ueda, Michiaki Mishima, Shinya Yamamoto, Hiroaki Ozasa, Hitoshi Masuda, Tetsuya Fukumoto, Takashi Daimon, Nozomu Tanji, Shigeru Tansho-Nagakawa, Ledicia Álvarez-Paredes, Junji Yonese, Markos Marangos, Hajime Tanaka, Ruth Chapman, Kriton S. Filos, Ian M. Gould, Tsuneyuki Ubagai, Yasuo Ono, Aron Popovtzer, Druckerei Stückle, Takeshi Yuasa, Evangelos D. Anastassiou, Carlos Fernandez Teruel, Iris Spiliopoulou, Tomoko Nishimura, Tadahiko Kikugawa, Yasuhisa Fujii, Yutaka Yanagihara, Efthimia Petinaki, Kazuyuki Inoue, Samnang Nguon, Koji Azuma, Kevin Marsh, Maung Maung Myat Moe, Satz Mengensatzproduktion, Ladislav Kokoska, Juan Carlos Rodríguez, Mizuaki Sakura, Liat Vidal, Masahiro Hatori, Montserrat Ruiz-García, Nikolaos Giormezis, Apostolos Liakopoulos, Masayoshi Yokoyama, Daiki Tsuji, Miguel Santibáñez, Kunihiko Itoh, Sofía Belda, Xiaoqin Mu, Matthaios Papadimitriou-Olivgeris, and Hironobu Sunadome

Subjects
Pharmacology, Infectious Diseases, Oncology, Drug Discovery, Pharmacology (medical), General Medicine
Published
2013
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2. Effects of Erythromycin and Rifampicin on Immunomodulatory Gene Expression and Cellular Function in Human Polymorphonuclear Leukocytes

Author

Tsuneyuki Ubagai, Hirotoshi Kikuchi, Xiaoqin Mu, Takane Kikuchi-Ueda, Ryuichi Nakano, Shigeru Tansho-Nagakawa, and Yasuo Ono

Subjects
Lipopolysaccharides, Neutrophils, medicine.drug_class, Antibiotics, Lipopolysaccharide Receptors, Down-Regulation, Erythromycin, Biology, Real-Time Polymerase Chain Reaction, Microbiology, Immunomodulation, Downregulation and upregulation, Drug Discovery, Gene expression, polycyclic compounds, medicine, Humans, Pharmacology (medical), RNA, Messenger, Receptor, Pharmacology, Receptors, Interleukin-8, Tumor Necrosis Factor-alpha, Toll-Like Receptors, General Medicine, Flow Cytometry, Anti-Bacterial Agents, Infectious Diseases, Real-time polymerase chain reaction, Oncology, Tumor necrosis factor alpha, Rifampin, Reactive Oxygen Species, Rifampicin, medicine.drug
Abstract

Background: We investigated the effects of two antibiotics, erythromycin and rifampicin, on the immunomodulatory gene expression and cellular function of human polymorphonuclear leukocytes (PMNs). Methods: We used real-time quantitative PCR to examine the expression of immunomodulatory genes. The production of reactive oxygen species (ROS) was determined by fluorescence-activated cell sorting. PMN chemotaxis was analyzed using a KK chemotaxis chamber. Results: Stimulation of PMNs with lipopolysaccharide (LPS) resulted in increases in the mRNA levels of immunomodulatory genes. Rifampicin significantly inhibited the overexpression of TLR2, TLR4, CD14 and IL8Rs. However, erythromycin suppressed only the upregulation of TLR2 and TNFA. Neither antibiotic had an effect on the production of ROS. Rifampicin significantly inhibited PMN chemotaxis, but erythromycin had no effect. Conclusions: Erythromycin and rifampicin may play anti-inflammatory roles by affecting the expression levels of immunomodulatory genes or the chemotaxis of PMNs.

Published
2013
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