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1. Contents, Vol. 58, 2012

Author

Seong Joon Park, Suee Lee, Yuki Akazawa, Li-Ming Peng, Xiao-dong Wang, Alessandro Lia Mondelli, Takashi Meguro, Elvira Garza-González, Ni Chen, Dae-Ho Lee, Toru Kumagai, Chun-mei Huang, Ji Hyun Lee, Atsushi Takada, Hyuk-Chan Kwon, Inkeun Park, Mineo Kudo, Minoru Uebayashi, Hiroshi Nakatsumi, Koji Oba, Satoshi Yuki, Christian A. Graves, Taishi Harada, Feng Bi, Wen Zhang, Cheryn Song, Kenichiro Nagata, Junji Uchida, Ioannis A. Voutsadakis, Zhi-ping Li, Nana Aono, Kevin Camphausen, Sung Hyun Kim, Susumu Sogabe, Antonia Digklia, Xu Li, Masanori Sueyasu, Masahiro Asaka, Shuichi Muto, Hong-Sheng Wen, Shin Ahn, Qiu-lin Tang, Yoshito Komatsu, Jae-Lyun Lee, Cui-Cui Zhang, Carlos Henrique Camargo, Druck Reinhardt Druck Basel, Sung Yong Oh, Kanji Kato, Hiroaki Ikesue, Kwonoh Park, Wei Wang, Yoichi Nakanishi, Koichi Takayama, Takako Okuyama, Adriano Martison Ferreira, Yu-Zhu Cao, Fumio Imamura, Satz Mengensatzproduktion, Fang Yang, Yongcheol Ahn, Samantha Flores, Marina Oshiro, Kazumi Nishino, Choung-Soo Kim, Ryozo Oishi, Hanjong Ahn, Hiroyuki Watanabe, Hyojin Kim, Yuri Ito, Jin-Hee Ahn, Kazuto Mishima, Qian Deng, Soraya Mendoza-Olazarán, Takuto Miyagishima, Yu-Ming Shi, Li Li, Tetsuhiro Yoshinami, Kimitaka Suetsugu, Adrián Camacho-Ortiz, Miki Tateyama, Mariana Fávero Bonesso, Jorge M. Llaca-Díaz, Maria de Lourdes Ribeiro de Souza da Cunha, Nobuaki Egashira, and Jun Hyuk Hong

Subjects
Pharmacology, Infectious Diseases, Oncology, Drug Discovery, Pharmacology (medical), General Medicine
Published
2012

2. Risk factors for predicting severe neutropenia induced by amrubicin in patients with advanced lung cancer

Author

Kimitaka Suetsugu, Hiroyuki Watanabe, Yoichi Nakanishi, Marina Oshiro, Nobuaki Egashira, Kazuto Mishima, Ryozo Oishi, Taishi Harada, Masanori Sueyasu, Kenichiro Nagata, Atsushi Takada, Hiroaki Ikesue, and Koichi Takayama

Subjects
Adult, Male, medicine.medical_specialty, Lung Neoplasms, Neutropenia, Antineoplastic Agents, Hematocrit, Severity of Illness Index, Sex Factors, Predictive Value of Tests, Risk Factors, Internal medicine, Drug Discovery, Severity of illness, medicine, Electronic Health Records, Humans, Pharmacology (medical), Anthracyclines, Lung cancer, Aged, Retrospective Studies, Pharmacology, medicine.diagnostic_test, Dose-Response Relationship, Drug, business.industry, Incidence (epidemiology), Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Surgery, Infectious Diseases, Logistic Models, Oncology, Predictive value of tests, Multivariate Analysis, Female, business, Amrubicin
Abstract

Background: Neutropenia is one of the most frequent and dose-limiting toxicities in amrubicin (AMR) therapy. However, the predictive factors for the development of severe neutropenia in AMR therapy remain unknown. Methods: The subjects were 61 advanced lung cancer patients treated with AMR monotherapy. All data were retrospectively collected from the electronic medical record system. A stepwise logistic regression analysis was performed to identify risk factors for grade 3–4 neutropenia. Results: Of a total 61 patients, 50 were male and 11 were female. The median dose of AMR was 35.0 mg/m2. The incidence of grade 3–4 neutropenia during the first course was 62%. In multivariate analysis, female gender (OR = 6.68; 95% CI 1.01–134.15; p = 0.049), higher AMR doses (40 mg/m2 or more) (OR = 5.98; 95% CI 1.77–23.74; p = 0.003), and lower hematocrit values (OR = 2.04 per 5% decrease; 95% CI 1.04–4.38; p = 0.036) were significantly associated with severe neutropenia induced by AMR. Conclusion: The present results suggest that female gender, higher doses of AMR, and lower baseline hematocrit values are predictive factors associated with severe neutropenia induced by AMR in patients with advanced lung cancer. Patients who have these predictive factors should be monitored carefully and considered for early granulocyte colony-stimulating factor support.

Published
2012

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