1. In vitro Effect of Natural and Semi-Synthetic Carbohydrate Polymers on Chlamydia trachomatis Infection
- Author
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Maria Grazia Petronio, S. Pisani, C. Gallinelli, Antonella Mansi, Fernanda Chiarini, and Lucilla Seganti
- Subjects
Pharmacology ,chemistry.chemical_classification ,Glycogen ,General Medicine ,Biology ,Carbohydrate ,Antimicrobial ,medicine.disease_cause ,biology.organism_classification ,Polysaccharide ,In vitro ,Microbiology ,chemistry.chemical_compound ,Infectious Diseases ,Oncology ,chemistry ,Drug Discovery ,medicine ,Pharmacology (medical) ,Chlamydiaceae ,Chlamydia trachomatis ,Antibacterial agent - Abstract
The effect of different natural and semi-synthetic polysaccharides on Chlamydia trachomatis multiplication in Hela 229 cells was evaluated. Some neutral, negatively and positively charged carbohydrates were able, in a dose-dependent fashion, to inhibit chlamydial infection by interfering mainly with the adsorption process. The inhibiting compounds, whose effect was shown within the concentration range of 8-200 micrograms/ml, were in order of action: dextran sulphate > glyloid sulphate 4327 > glycogen sulphate 4427 > arabic gum = glyloid > chitosan > glycogen. Data obtained suggested that antichlamydial activity was not only related to the electric charge of these molecules but could also be attributed to other features of their polymeric backbone. Since carbohydrate polymers have also been shown to inhibit the early stages of infection by viral agents causing sexually transmitted diseases, the employment of these molecules for prevention or treatment of mixed viral-C. trachomatis infections can be hypothesized.
- Published
- 1997