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4 results on '"Annarita Fabiano"'

1. Contents Vol. 54, 2008

Author

J.N. Yue, Xiaomin Luo, Ding-An Zhou, C. Almeida, Akiko Ito, Shigeru Kohno, Valentina Lombardi, Hisahiro Yoshida, A. Maleddu, Yoji Ikegami, Kazumi Sano, R.S. Guo, Carlo Barone, E. Martín-Mazuelos, M.A. Pantaleo, M.C. Serrano, Jiayong Chen, Yoichi Nakamura, Yong-Chang Yang, A. Valverde, Koen De Vis, S. Fanti, Annamaria Piscazzi, Jian Li, Yi Zhang, Paolo Pedrazzoli, Giuseppe Daidone, Xiaoting Wu, Matteo Landriscina, Farheen Shah-Khan, Hiroshi Soda, Sung Yong Oh, J.Y. Li, Ilaria Schiavetto, Qi Hu, G. Samonis, Hyun Jin Kim, Megumi Yoshikawa, A.T. Zisiou, Probodh Shah, E. Mantadakis, Wen Liu, Z.W. Quan, Tae Hyo Kim, Yong Yuan, Giovanni Brandi, Ya-Li Zeng, Dai-Wen Xiao, Mauro Cignarelli, Lin Li, Benedetta Maggio, T. Anastasopoulos, Lili Fu, Alberto Fersini, Salvatore Siena, J. Pemán, D.P. Kofteridis, S. Maraki, Mikio Oka, Wen-Fang Huang, Jung Hun Kang, Daoming Liang, G. Notas, M. Farsad, Vera Basilico, Maria Valeria Raimondi, Gyeong-Won Lee, S. Fanello, Demetrio Raffa, Xishan Xiong, Maria Grazia Cusimano, Bo Huang, Stella Cascioferro, Annarita Fabiano, Domenico Schillaci, G. Biasco, Guo-Qiang Xu, M. Nannini, Changlin Mei, Liang-Min Chuan, Michele Santodirocco, Hoon Gu Kim, C. Castro, G. Papazoglou, Hong Liu, M. Di Battista, Y.Y. Qin, Hirofumi Nakano, Kurika Satake, S.G Li, G. Ercolani, and Seigo Sawada

Subjects
Pharmacology, Infectious Diseases, Oncology, Drug Discovery, Pharmacology (medical), General Medicine
Published
2008

2. Nevirapine Toxicity in Non-HIV Cancer Patients

Author

Mauro Cignarelli, Carlo Barone, Matteo Landriscina, Alberto Fersini, Valentina Lombardi, Annamaria Piscazzi, Koen De Vis, Annarita Fabiano, and Michele Santodirocco

Subjects
Nevirapine, HIV Infections, Immune system, immune system diseases, Drug Discovery, Humans, Medicine, Pharmacology (medical), Thyroid Neoplasms, Aged, Neoplasm Staging, Pharmacology, Reverse-transcriptase inhibitor, business.industry, virus diseases, Cancer, General Medicine, Middle Aged, medicine.disease, Virology, Infectious Diseases, Oncology, Toxicity, Hiv patients, Neoplasm staging, business, Human cancer, medicine.drug
Abstract

Background: Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with severe immune-mediated toxicities in non-HIV individuals. Methods and Results: We describe the toxicity profile of single-agent NVP in 6 non-HIV cancer patients treated for a median period of 7.3 months (range 1–24), reporting only a reversible grade III increase in glutamyl transpeptidase and glutamic pyruvic transaminase serum values. Interestingly, NVP treatment correlates with either a decrease in CD8+ T cell counts or a parallel increase in CD4/CD8 ratio, antithyroglobulin and antithyroid peroxidase autoantibody titers. Conclusions: These results, although obtained in a small cohort of patients, suggest that the toxicity profile of single-agent NVP may be worth testing in a phase I/II study in non-HIV cancer patients and that NVP toxicity may depend on its capacity to trigger autoimmune responses in susceptible individuals.

Published
2008

3. Subject Index Vol. 54, 2008

Author

M. Di Battista, Qi Hu, A.T. Zisiou, Ding-An Zhou, Changlin Mei, Carlo Barone, Vera Basilico, C. Almeida, G. Biasco, Y.Y. Qin, Hirofumi Nakano, Guo-Qiang Xu, M. Nannini, Paolo Pedrazzoli, Kurika Satake, Jian Li, Liang-Min Chuan, Salvatore Siena, Yong Yuan, Koen De Vis, S. Fanti, Akiko Ito, Shigeru Kohno, C. Castro, S.G Li, Michele Santodirocco, Matteo Landriscina, R.S. Guo, J.N. Yue, Hong Liu, G. Ercolani, Xiaoting Wu, E. Martín-Mazuelos, Yong-Chang Yang, A. Valverde, Wen Liu, Maria Grazia Cusimano, J. Pemán, Seigo Sawada, Mikio Oka, D.P. Kofteridis, Giovanni Brandi, Megumi Yoshikawa, Lin Li, Giuseppe Daidone, G. Samonis, Hoon Gu Kim, S. Fanello, E. Mantadakis, Xishan Xiong, G. Notas, Dai-Wen Xiao, S. Maraki, Domenico Schillaci, M.A. Pantaleo, M. Farsad, Yoji Ikegami, Kazumi Sano, M.C. Serrano, Bo Huang, Stella Cascioferro, Jiayong Chen, Demetrio Raffa, Lili Fu, Probodh Shah, Annarita Fabiano, Alberto Fersini, Jung Hun Kang, Daoming Liang, Gyeong-Won Lee, Tae Hyo Kim, Mauro Cignarelli, G. Papazoglou, A. Maleddu, Farheen Shah-Khan, Hyun Jin Kim, Hiroshi Soda, Ilaria Schiavetto, Valentina Lombardi, J.Y. Li, Xiaomin Luo, T. Anastasopoulos, Annamaria Piscazzi, Hisahiro Yoshida, Yoichi Nakamura, Maria Valeria Raimondi, Z.W. Quan, Ya-Li Zeng, Benedetta Maggio, Wen-Fang Huang, Yi Zhang, and Sung Yong Oh

Subjects
Pharmacology, Infectious Diseases, Index (economics), Oncology, Drug Discovery, Statistics, Pharmacology (medical), Subject (documents), General Medicine, Mathematics
Published
2008

4. Acknowledgement to the Reviewers

Author

E. Mantadakis, Salvatore Siena, M.C. Serrano, C. Almeida, Lili Fu, Z.W. Quan, Ya-Li Zeng, J.Y. Li, Maria Grazia Cusimano, J.N. Yue, Hisahiro Yoshida, Jian Li, R.S. Guo, Alessandra Maleddu, Mohsen Farsad, Qi Hu, Guido Biasco, Yoichi Nakamura, Yoji Ikegami, Kazumi Sano, Hoon Gu Kim, Wen-Fang Huang, A.T. Zisiou, Jiayong Chen, Koen De Vis, Xiaoting Wu, Wen Liu, Domenico Schillaci, Yong Yuan, Giuseppe Daidone, Akiko Ito, Shigeru Kohno, Megumi Yoshikawa, S. Maraki, Benedetta Maggio, Changlin Mei, Silvia Fanello, Ding-An Zhou, Tae Hyo Kim, Margherita Nannini, Stefano Fanti, Jung Hun Kang, Daoming Liang, E. Martín-Mazuelos, Yong-Chang Yang, A. Valverde, Alberto Fersini, C. Castro, Dai-Wen Xiao, Paolo Pedrazzoli, Mauro Cignarelli, Demetrio Raffa, G. Samonis, Giovanni Brandi, Xiaomin Luo, Guo-Qiang Xu, Liang-Min Chuan, Bo Huang, Stella Cascioferro, Lin Li, Annamaria Piscazzi, Annarita Fabiano, Probodh Shah, Michele Santodirocco, Valentina Lombardi, M. A. Pantaleo, G. Papazoglou, Yi Zhang, Sung Yong Oh, Carlo Barone, Matteo Landriscina, Kurika Satake, S.G Li, Hong Liu, M. Di Battista, Y.Y. Qin, Hirofumi Nakano, Seigo Sawada, Giorgio Ercolani, Farheen Shah-Khan, Hyun Jin Kim, G. Notas, Gyeong-Won Lee, Xishan Xiong, D.P. Kofteridis, Vera Basilico, J. Pemán, Mikio Oka, Hiroshi Soda, Ilaria Schiavetto, T. Anastasopoulos, and Maria Valeria Raimondi

Subjects
Pharmacology, Medical education, Infectious Diseases, Oncology, Drug Discovery, Acknowledgement, Pharmacology (medical), General Medicine, Psychology
Published
2002

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