1. Simultaneous liquid chromatography-tandem mass spectrometry analysis of brominated flame retardants (tetrabromobisphenol A and hexabromocyclododecane diastereoisomers) in French breast milk
- Author
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Virginie Rigourd, Frédéric Hommet, François Bordet, Chanthadary Inthavong, Thierry Guérin, and Sylviane Dragacci
- Subjects
Environmental Engineering ,010504 meteorology & atmospheric sciences ,Health, Toxicology and Mutagenesis ,Polybrominated Biphenyls ,010501 environmental sciences ,Isotope dilution ,Mass spectrometry ,01 natural sciences ,chemistry.chemical_compound ,Liquid chromatography–mass spectrometry ,Limit of Detection ,Tandem Mass Spectrometry ,Environmental Chemistry ,Humans ,0105 earth and related environmental sciences ,Flame Retardants ,Detection limit ,Hexabromocyclododecane ,Chromatography ,Milk, Human ,Extraction (chemistry) ,Public Health, Environmental and Occupational Health ,General Medicine ,General Chemistry ,Pollution ,Hydrocarbons, Brominated ,chemistry ,Maternal Exposure ,Environmental chemistry ,Tetrabromobisphenol A ,Female ,France ,Breast feeding ,Chromatography, Liquid - Abstract
TBBPA and HBCDs are the two classes of flame retardants that are still allowed for use by the European Commission. In May 2013, HBCDs were listed as Persistent Organic Pollutants under the Stockholm Convention, and they were banned with an exemption on EPS/XPS for cavity wall insulation. This study describes the development and optimisation of a rapid LC-ESI-MS/MS method using isotopic dilution quantification including a simplified extraction step using a mixture of solvents and sulphuric acid hydrolysis followed by the one-shot analysis of TBBPA and each of the α-, β- and γ-HBCD diastereoisomers. The limits of detection and quantification (LOD and LOQ) were 0.5 and 2.5 ng g−1 (lipid weight, lw) for TBBPA and HBCD diastereoisomers, respectively. The method was applied to analyse 106 samples of individual mature breast milk. TBBPA was quantified in 42% of these samples within a range of
- Published
- 2017