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The Adriatic Sea is an enclosed basin threatened by marine pollution due to its hydrographic features and anthropogenic pressure. Although zooplankton has been worldwide regarded as an immediate warning signal of contamination, limited information is available on the contamination of these organisms at the Adriatic level. Hence, this study provides comprehensive data on the presence and levels of multiple pollutants in zooplankton collected from 46 locations. With regards to legacy contaminants, both PCB and DDT levels have declined since the 1980s. Specifically, most samples were characterized by low DDT contamination (average of 3 ± 2.7 ng g− 1 dry weight) and only few of these accumulated levels of concern for what concerns PCB, pointing out possible hotspots of contamination in the central-eastern Adriatic Sea. As regards metal(loid)s, the Metal Pollution Index identified areas of concern in the north Adriatic Sea (Gulf of Venice) with high levels of Co, Cu, Hg, Cr and Pb; in the Central Adriatic Sea (Tremiti islands) with high levels of Co, Ni, Hg, Cr and Pb; in the Southern Adriatic Sea (Taranto and offshore Corfu), with high levels of most metal(loid)s, especially Cr, Ni and Zn. Certain metal(loid)s (e.g. Cd, Pb and Hg) have declined over time and most of them are lower than well-known contaminated worldwide marine ecosystems. Only Cu appears to be particularly high in the Mediterranean zooplankton. Overall, this work suggests a general improvement of the status of contamination of the Adriatic Sea. [Display omitted] • This study evaluated the contamination status of the Adriatic Sea using zooplankton. • PCB and DDT contamination appears to be declining over the past 50 years. • DDT levels are comparable to pristine and less impacted areas worldwide. • Data on trace elements pointed out some hotspots within the basin. • Most TE levels in zooplankton are lower than renowned worldwide contaminated areas. [ABSTRACT FROM AUTHOR]

Polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF), namely known as dioxins, are persistent organic compounds with high toxicity. The presence of dioxins in soil is a major environmental issue worldwide, as it negatively impacts both ecosystems and human health. Thus, several advanced techniques have been applied to overcome this issue, offering promising treatment efficiency and cost-effectiveness. This review employs a meta-analysis strategy to provide an up-to-date assessment of the global situation of dioxin-contaminated soil. Dioxin concentrations are commonly higher in industrial and urban areas than in rural areas, primarily due to anthropogenic activities such as chemical manufacturing and waste incineration. Furthermore, several advanced bioremediation technologies for dioxin treatment, including biosurfactants, composting, and phytoremediation were highlighted and thoroughly discussed. Aerobic composting has proven to be robust in removing dioxins, achieving treatment efficiencies ranging from 65% to 85%. Whereas, phytoremediation, particularly when involving agricultural crops like zucchini, cucumber, and wheat, shows great promise in dioxin removal through various mechanisms, including root uptake and transpiration. Notably, biosurfactants such as rhamnolipids and sophorolipids have been effectively used to remediate dioxin-contaminated soil due to their significantly enhanced bioavailability of dioxins and their interaction with microbes. This review provides a comprehensive understanding of advanced biotechnologies for remediating dioxin-contaminated soil. It also addresses the technical and economic aspects of dioxin treatment and identifies future directions and research perspectives to fill knowledge gaps in this field. [Display omitted] • Dioxin concentrations are commonly observed to be higher in industrial and urban areas. • Microbes efficiently dechlorinate dioxins by utilizing them as a carbon and energy source. • Phytoremediation approach is very promising to remediate dioxin-contaminated soil. • Aerobic composting is more effective for less chlorinated congeners and faster than anaerobic composting. • Biosurfactant is a cost-effective and highly effective method for dioxin remediation. [ABSTRACT FROM AUTHOR]

Environmental microplastics (MPs) are complex mixtures of plastic polymers and sorbed chemical pollutants with high degrees of heterogeneity, particularly in terms of particle size, morphology and degree of weathering. Currently, limitations exist in sampling sufficient amounts of environmental particles for laboratory studies to assess toxicity endpoints with statistical rigor and to examine chemical pollutant interactions. This study seeks to bridge this gap by investigating environmental plastic particle mimetics and pollutant-polymer interactions by mixing polymer particles with persistent organic pollutants (POPs) at set concentrations over time. Solutions containing combinations of polymers including polystyrene (PS), polypropylene (PP), polyethylene terephthalate (PET), and polyamide (PA) and POPs including 2,3,7,8 -Tetrachlorodibenzo-p-dioxin (TCDD), bisphenol A (BPA), and atrazine, were stirred for up to 19 weeks and monitored using assays to test for aryl hydrocarbon (AhR) and estrogen receptor (ER) activity which are cell signaling pathways impacted by environmental pollutants. TCDD induced AhR activity decreased over time in the presence of PS in a surface area dependent manner. BPA and atrazine also exhibited AhR antagonist activity in the presence of TCDD. The addition of BPA slowed the loss of activity but atrazine did not, suggesting that polymer chemistry impacts interactions with POPs. We also observed potential differences in TCDD sorption with different plastic polymers and that higher concentrations of PS particles may inhibit BPA-induced estrogen receptor activation. These results emphasize the need for additional understanding of how POPs and polymer chemistry impact their interaction and toxicity. [Display omitted] • Polystyrene particles differentially interact with TCDD, BPA and atrazine. • Polystyrene particles decrease TCDD-induced AhR activity in a surface area dependent manner. • BPA and atrazine inhibit TCDD-induced AhR activity over time. • BPA hinders TCDD-polystyrene particle sorption but atrazine does not. • Polystyrene particles inhibit BPA-induced estrogen activation. [ABSTRACT FROM AUTHOR]

Bromochloro alkanes (BCAs) are a class of flame retardants similar in structure to polychlorinated alkanes (PCAs), which are the major component of short-chain chlorinated paraffins (SCCPs) listed as Persistent Organic Pollutants under the Stockholm Convention. BCAs have recently been detected for the first time in environmental samples. Due to the complete lack of commercially available analytical standards, no method for quantifying BCAs has been reported to date. In this study, 16 custom-synthesised standards with mixed bromine and chlorine halogenation and carbon chain lengths ranging from C 10 to C 17 were characterized by liquid chromatography and Orbitrap high-resolution mass spectrometry and used to assess the applicability of pattern deconvolution quantification strategies for BCAs in indoor dust. Br 1-9 and Cl 1-8 BCAs were detected as [M + Cl] - adduct ions among the C 10 to C 17 standards, as well as numerous PCA homologues. After applying correction factors to account for the presence of PCAs in the standards, triplicate fortification experiments using varied halogenation composition and concentration determined an average measurement accuracy of 81% over the carbon chain lengths studied and coefficient of variance ≤20% between replicates. Overall, approximately 89% of the ΣBCA concentrations quantified in the fortification trials met the European Union Reference Laboratory's accuracy acceptability criteria recommended for PCAs, between 50 and 150%. Application of the BCA pattern deconvolution quantification procedure to seven representative indoor dust samples from the United States of America revealed a low correlation between the homologue distribution in the samples and the prototype standards (R 2  ≤ 0.40), which precluded reliable quantification. This study indicates that pattern deconvolution is an appropriate strategy for quantifying BCAs in environmental samples, but that a large set of appropriate mixture standards will be required before more reliable estimates of BCA concentrations can be achieved in indoor dust., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

The fate and distribution of environmental contaminants includes bioaccumulation within marine organisms. A deceased 4-m long adult female bluntnose sixgill shark, pregnant with 72 pups, was recovered from Coles Bay on Vancouver Island, BC, Canada in 2019. This specimen provided a unique opportunity to examine maternal transfer of contaminants in a yolk-sac viviparous shark species. Liver subsamples of the adult and offspring were analyzed for 18 targeted inorganic elements by inductively coupled plasma optical emission spectroscopy (ICP-OES) and 21 targeted perfluoroalkyl substances (PFAS) by liquid chromatography-electrospray ionization-high resolution mass spectrometry (LC-ESI-Orbitrap MS). The maternal-offspring transfer efficiencies in liver tissue were subsequently examined for both contaminant classes. Concentrations of all detectable metals apart from calcium and magnesium were found to be higher in the mother compared to the offspring, including substantial levels of toxic cadmium (6 ± 2 mg kg−1 dw) and lead (7 ± 3 mg kg−1 dw). Conversely, high maternal transfer efficiencies were observed for PFAS (i.e. , ΣPFAS = 71 ± 9 ng g−1 ww in offspring compared to 13 ± 9 ng g−1 ww in the mother). This study highlighted the unique maternal transfer characteristics of PFAS in bluntnose sixgill sharks depending on the structure of the polar head group, with greater liver-to-liver transfer efficiencies observed for perfluorocarboxylic acids (PFCAs) than perfluorosulfonic acids (PFSAs) of the same fluorocarbon chain length. [Display omitted] • Pregnant lecithotrophic viviparous sixgill shark was recovered from the North Pacific Ocean. • Perfluoroalkyl substances (PFAS) and trace metals analyzed in shark livers. • High maternal transfer of PFAS, especially perfluorinated carboxylic acids. • Low maternal transfer of metals, including cadmium and lead. [ABSTRACT FROM AUTHOR]

Persistent organic pollutants (POPs) bioaccumulate in the food chain and can cause ecotoxicity. In wild bird populations, various tissues are used to determine POP levels, including invasive (e.g., brain, fat, kidney, liver, muscle) and minimally-invasive tissues (e.g., blood, feather, preen oil). Minimally-invasive sampling, which does not require the death of the animal, opens new prospects for sampling birds as sentinels of environmental pollution and its consequences on fitness. However, POP variability between tissues is understudied, which is an essential prerequisite for making a reasoned choice about which tissues to sample. Here, we performed a meta-analysis of eight tissues across 115 studies comparing tissues across POP groups. We demonstrate increased use of minimally-invasive measures between 1974 and 2020. When grouping tissue correlations into three groups, "invasive:invasive", "invasive:minimally-invasive" and "minimally-invasive:minimally-invasive", we found that all three groups produced moderate to strong positive correlations with no difference seen between comparison groups. We demonstrate (1) lower POP concentrations in preen oil than fat, but no difference in detection frequencies, supporting preen oil use; (2) blood showed high concentration variability dependent on POP group but detection frequencies were comparable to liver and kidney; and (3) feathers demonstrated a significantly lower detection frequency than other matrices measured. By further researching minimally-invasive tissues, we increase our understanding of whether minimally-invasive tissues are ecologically representative of body-level toxicity. Our study supports blood and preen oil as substitutes for invasive measures when sampling living bird populations as they represent internal POP concentrations and provide significant benefits both practically and ethically., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Seawater warming, ocean acidification and chemical pollution are the main threats to coral growth and even survival. The legacy persistent organic contaminants (POCs), such as polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), and the emerging contaminants, including polybrominated diphenyl ethers (PBDEs), dechlorane plus (DPs) and novel brominated flame retardants (NBFRs) were studied in corals from Luhuitou fringing reef in Sanya Bay and Yongle atoll in Xisha Islands, the South China Sea (SCS). Total average concentrations of ∑ 16 PAHs, ∑ 23 OCPs, ∑ 34 PCBs, ∑ 8 PBDEs, ∑ 2 DPs and ∑ 5 NBFRs in 20 coral species (43 samples) from the SCS were 40.7 ± 34.6, 5.20 ± 5.10, 0.197 ± 0.159, 3.30 ± 3.70, 0.041 ± 0.042 and 36.4 ± 112 ng g -1 dw, respectively. PAHs and NBFRs were the most abundant compounds and they are likely to be dangerous pollutants for future coral growth. Compared to those found in other coral reef regions, these pollutants concentrations in corals were at low to median levels. Except for PBDEs, POCs in massive Porites were significantly higher than those in branch Acropora and Pocillopora (p < 0.01), as large, closely packed corals may be beneficial for retaining more pollutant. The current study contributes valuable data on POCs, particularly for halogenated flame retardants (HFRs, including PBDEs, DPs and NBFRs), in corals from the SCS, and will improve our knowledge of the occurrence and fate of these pollutants in coral reef ecosystems., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Titanium dioxide (TiO 2 ) is an important industrial chemical, and studies suggest its major production route - the chloride process could lead to the generation of unintentional dl-POPs. However, no relevant studies assessed the occurrence of dl-POPs associated with TiO 2 production in the industrial zones, which is mostly due to the ultra-trace level distribution of these compounds in environmental compartments. The present study explored the novel possibility of utilising foraging animal-origin foods as sensitive indicators for addressing this challenge and generated a globally beneficial dataset by assessing the background levels of dl-POPs in the vicinity of a TiO 2 production house in Southern India. Systematic sampling of foraging cow's milk and free-ranging hen's eggs was carried out from the study site, and the dl-POPs assessments were conducted utilising an in-house developed cost-effective GC-MS/MS-based analytical methodology. The median dl-POPs levels in milk and egg samples were about 3 times higher than the control samples collected from farm-fed animals and retail markets. The contaminant loads in the foraging animal-origin food samples were further traced to their presence in environmental compartments of soil and sediment and admissible degree of correlations were observed in congener fingerprints. Elevated health risks were inferred for the population in the industrial zones with weekly intakes weighing about 0.15-17 times the European Food Safety Authority-assigned levels. The consumption of foraging cow's milk was observed to have a higher contribution towards the hazard indices and cancer risk estimates and were significantly higher (p < 0.05) for children. The study also presents a critical validation of the GC-MS/MS-based method for the purpose of regulatory monitoring of dl-POPs, which could be of practical significance in economies in transition., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

The European Commission's current efforts to launch the largest proposal to restrict per- and polyfluoroalkyl substances (PFAS) in history reflect the dire global plight of PFAS accumulation in the environment and their health impacts. While there are existing studies on PFAS research, there is a lack of comprehensive analysis that both covers the entire research period and provides deep insights into global research patterns, incentives, and barriers based on various parameters. We have been able to demonstrate the increasing interest in PFAS research, although citation numbers are declining prematurely. Policy regulations based on proving and establishing the toxicity of PFASs have stimulated research in developed countries and vice versa, with increasing emphasis on ecological aspects. China, in particular, is investing increasingly in PFAS research, but without defining or implementing regulations - with devastating effects. The separation of industrial and environmental research interests is clear, with little involvement of developing countries, even though their exposure to PFAS is devastating. It, therefore, requires increased globally networked and multidisciplinary approaches to address PFAS contamination challenges. [Display omitted] • Currently, China has the most publications, ahead of the USA and European countries. • Research focuses are strictly separated into ecological and material science topics. • Russia and Ukraine are among the frontrunners with a clear focus on materials science. • The focus in PFAS research is shifting toward ecological issues. • A national imbalance can be observed that leaves the low economies behind. [ABSTRACT FROM AUTHOR]

Most previous studies have focused primarily on the adverse effects of environmental chemicals on organisms of good healthy. Although global prevalence of non-alcoholic fatty liver disease (NAFLD) has reached approximately 25%, the impact of environmentally persistent organic chemicals on organisms with NAFLD is substantially unknown. Polyhalogenated carbazoles (PHCZs) as emerging contaminants have been frequently detected in the environment and organisms. In this study, we investigated the impact of the most frequently detected PHCZs, 3,6-dichlorocarbazole (36-CCZ), on zebrafish with high-fat diet (HFD)-induced NAFLD. After 4 weeks exposure to environmentally relevant concentrations of 36-CCZ (0.16–0.45 μg/L), the accumulation of lipid in zebrafish liver dramatically increased, and the transcription of genes involved in lipid synthesis, transport and oxidation was significantly upregulated, demonstrating that 36-CCZ had exacerbated the NAFLD in zebrafish. Lipidomic analysis indicated that 36-CCZ had significantly affected liver lipid metabolic pathways, mainly including glycerolipids and glycerophospholipids. Additionally, fifteen lipids were identified as potential lipid biomarkers for 36-CCZ exacerbation of NAFLD, including diacylglycerols (DGs), triglycerides (TGs), phosphatidylcholines (PCs), phosphatidylethanolamines (PEs), phosphatidic acid (PA), and phosphatidylinositol (PI). These findings demonstrate that long-term exposure to 36-CCZ can promote the progression of NAFLD, which will contribute to raising awareness of the health risks of PHCZs. [Display omitted] • Exposure to 36-CCZ (0.16–0.45 μg/L) exacerbate the progress of NAFLD in zebrafish. • Genes of lipid metabolism were investigated for 36-CCZ exacerbation of NAFLD. • Lipid metabolism pathways in 36-CCZ exacerbation of NAFLD have been revealed. • Fifteen potential lipid biomarkers have been identified. [ABSTRACT FROM AUTHOR]

Over the last two decades, Taiwan has effectively diminished atmospheric concentrations of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) through the adept utilization of advanced technologies and the implementation of air pollution control devices. Despite this success, there exists a dearth of data regarding the levels of other PM 2.5 -bound organic pollutants and their associated health risks. To address this gap, our study comprehensively investigates the spatial and seasonal variations, potential sources, and health risks of PCDD/Fs, Polychlorinated biphenyls (PCBs), and Polychlorinated naphthalene (PCNs) in Northern and Central Taiwan. Sampling collections were conducted at three specific locations, including six municipal waste incinerators in Northern Taiwan, as well as a traffic and an industrial site in Central Taiwan. As a result, the highest mean values of PM 2.5 (20.3-39.6 μg/m 3 ) were observed at traffic sites, followed by industrial sites (14.4-39.3 μg/m 3 ), and the vicinity of the municipal waste incinerator (12.4-29.4 μg/m 3 ). Additionally, PCDD/Fs and PCBs exhibited discernible seasonal fluctuations, displaying higher concentrations in winter (7.53-11.9 and 0.09-0.12 fg I-TEQ WHO /m 3 ) and spring (7.02-13.7 and 0.11-0.16 fg I-TEQ WHO /m 3 ) compared to summer and autumn. Conversely, PCNs displayed no significant seasonal variations, with peak values observed in winter (0.05-0.10 fg I-TEQ WHO /m 3 ) and spring (0.03-0.08 fg I-TEQ WHO /m 3 ). Utilizing a Positive Matrix Factorization (PMF) model, sintering plants emerged as the predominant contributors to PCDD/Fs, constituting 77.9% of emissions. Woodchip boilers (68.3%) and municipal waste incinerators (21.0%) were identified as primary contributors to PCBs, while municipal waste incinerators (64.6%) along with a secondary copper and a copper sludge smelter (22.1%) were the principal sources of PCNs. Moreover, the study specified that individuals aged 19-70 in Northern Taiwan and those under the age of 12 years in Central Taiwan were found to have a significantly higher cancer risk, with values ranging from 9.26 x 10 -9 -1.12 x 10 -7 and from 2.50 x 10 -8 -2.08 x 10 -7 respectively., Competing Interests: Declaration of competing interest With the submission of this manuscript, I would like to confirm that this is an original work that has not been published before and is not currently being considered for submission to other journals. I also confirm that the journal's author notes have been read carefully and all points have been compiled for the entire manuscript. All authors have approved and agreed to contribute to the “Chemosphere”., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

The present study compares the effect of using different solvents on the electrochemical properties of the reduced TiO 2 nanotubes (TiO 2 -rNTs) layered Ti/TiO 2 -rNTs/SnO 2 -Sb/PbO 2 anodes. The electrodes are prepared using three different solvent-based precursors: (i) isopropanol, (ii) ethylene glycol and citric acid (Pechini method), and (iii) 2-hydroxyethylammonium acetate (2HEAA) ionic liquid (IL) via the thermal decomposition route. The decomposition mechanism of precursor solutions was explored using the thermogravimetric (TGA) analysis. Further, the physicochemical properties of the electrodes are examined using Field emission Scanning Electron microscopy (FE-SEM), X-ray diffraction spectroscopy (XRD), and X-ray photoelectron emission spectroscopy (XPS). The results revealed that solvents with higher viscosity and slower decomposition rates support better film uniformity and higher stability of the electrode. The TiO 2 -rNTs bottom layer and PbO 2 top layer helped obtain higher film stability, increased working potential window (2.2 V vs. SHE) of the electrode, and the repeatability of the results. The performance of different electrodes based on the precursor solution is found as IL ≫ Pechini > Isopropanol. 4-chlorophenol (4-CP) is used as a model pollutant to test the performance of IL-Ti/TiO 2 -rNTs/SnO 2 -Sb/PbO 2 anode in an anodic oxidation (AO) coupled electro-Fenton (EF) treatment. Further, the reliability of the electrode is evaluated by mineralizing other persistent organic pollutants (POPs) like tetracyclin, phenol, 2-chlorophenol (2-CP), and 2,4-dichlorophenol (2,4-DCP). Under the optimized conditions, the proposed system was able to mineralize the tetracyclin, phenol, 2-CP, 2,4-DCP, and 4-CP up to 78.91, 82.07, 74.96, 78.78, and 69.3 %, respectively. Moreover, the degradation mechanism of chlorophenols is proposed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Biomass-derived biochar shows broad promise for persistent organic pollutants (POPs) degradation and thus establishes a more sustainable homestead. However, effective catalytic performance is still challenging. Herein, an efficient catalyst (Prussian blue decorated wood-derived biochar, PBB) was constructed by introducing Prussian blue (PB) into wood-based biochar to activate peroxymonosulfate (PMS) for removing POPs. After anchoring of PB, the degradation performance of biochar was enhanced (degradation efficiency of methylene blue (MB, 20 mg/L) increased from 52% of biochar to 95% of PBB within 60 min). The PBB presents effective MB degradation performance with a wide pH value (3.0 < pH < 11.0) or co-existing diverse anions (Cl - , NO 3 - , H 2 PO 4 - , and HCO 3 - ). Electron paramagnetic resonance (EPR) analysis as well as electrochemical tests confirmed that the non-radical pathway ( 1 O 2 ) is the key to biochar activation of PMS, but by restricting PB into the biochar, the radical pathway (SO 4 •- and • OH), the non-radical pathway ( 1 O 2 ), and direct electron transfer can work together to activate PMS. In addition, the degradation efficiency could remain about 80% after five-time cyclic tests. This work elucidates the role of PB nanoparticles in enhancing biochar catalysts, which can inspire the development of a carbon-neutralized, cost-effective, and effective strategy for POPs removal., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Evidence on prenatal exposure to polychlorinated biphenyls (PCBs) and its effects on newborns and potential biological mechanisms is not well defined yet. Therefore, this study aimed to examine whether PCBs are associated with lipid profile and non-invasive markers of hepatocyte injuries in samples of blood obtained from the umbilical cord. This study included 450 mothers-newborn pairs. Umbilical levels of PCBs were measured using Gas Chromatography/Mass Spectrophotometry (GC/MS). Lipid profile including low-density lipoprotein (LDL-C), total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL-C), as well as liver enzymes i.e., alanine amino transferase (ALT), aspartate amino transferase (AST), γ-glutamyl-transferase (GGT) and alkaline phosphatase (ALP) were determined from umbilical cord blood samples. Quantile g-computation analysis was applied to evaluate the collective influence of PCBs on both lipid profiles and liver enzymes, along with the impact of lipid profiles on liver enzymes. Exposure to the mixture of PCBs was significantly associated with increases in ALP, AST, ALT, and GGT levels in cord blood samples, with increments of 90.38 U/L (95%CI: 65.08, 115.70, p < 0.01), 11.88 U/L (95%CI: 9.03, 14.74, p < 0.01), 2.19 U/L (95%CI:1.43, 2.94, p < 0.01), and 50.67 U/L (95%CI: 36.32, 65.03, p < 0.01), respectively. Additionally, combined PCBs exposure was correlated with significant increases in umbilical TG, TC, and LDL-C levels, with values of 3.97 mg/dL (95%CI: 0.86, 7.09, p = 0.01), 6.30 mg/dL (95%CI: 2.98, 9.61, p < 0.01), and 4.63 mg/dL (95%CI: 2.04, 7.23, p < 0.01) respectively. Exposure to the mixture of lipids was linked to elevated levels of AST and GGT in umbilical cord blood samples. Furthermore, a noteworthy mediating role of TC and LDL-C was observed in the association between total PCBs exposure and umbilical cord blood liver enzyme levels. Overall our findings suggested that higher levels of umbilical cord blood PCBs and lipid profile could affect liver function in newborns. [Display omitted] • Mixture PCBs exposure was associated with an increase in umbilical ALP, AST, ALT and GGT. • Mixture PCBs exposure was associated with an increase in umbilical TG, TC and LDL. • Lipid mixture levels was positively associated with higher umbilical AST and GGT. • TC and LDL mediate the relationship between total PCBs and liver enzymes. [ABSTRACT FROM AUTHOR]

Kogia sima and Kogia breviceps are apex predators of mesopelagic trophic webs being far from most anthropogenic threats. However, chemical pollutants and naturally synthesized compounds may travel long distances. This study aimed to use kogiid whales as sentinels of mesopelagic trophic webs in the Southwestern Atlantic Ocean. Persistent organic pollutants (POPs), e.g., polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT) and metabolites, mirex, hexachlorobenzene (HCB), polybrominated diphenylethers (PBDEs), pentabromoethylbenzene (PBEB) and hexabromobenzene (HBB), and the naturally produced methoxylated BDE (MeO-BDEs) were determined in the blubber of 16 K. sima and 15 K. breviceps. Among the organochlorine compounds, DDTs were the main group found in K. sima and in K. breviceps (1636.6 and 3983.3 ng g−1 lw, respective medians), followed by PCBs (425.9 and 956.1 ng g−1 lw, respectively), mirex (184.1 and 375.6 ng g−1 lw, respectively), and HCB (132.4 and 340.3 ng g−1 lw, respectively). As for the organobromine, the natural MeO-BDEs were predominant (1676.7 and 501.6 ng g−1 lw, respectively), followed by PBDEs (13.6 and 10.3 ng g−1 lw, respectively) and PBEB (2.2 and 2.9 ng g−1 lw, respectively). In general, POPs concentration was higher in K. breviceps than in K. sima. Conversely, MeO-BDEs concentration was higher in K. sima than in K. breviceps. Differences in concentrations in these sympatric odontocetes were attributed to distinct species, sampling sites, and biological parameters and suggest some level of niche segregation. It is noteworthy the long-range reach and bioaccumulation of these synthetic compounds in an unexplored habitat, that present an increasing economic interest. [Display omitted] • The mesopelagic Kogia sima and K. breviceps can be sentinels of deep-water habitats. • DDTs were the main group of organochlorines and MeO-BDEs of organobromines detected. • PBEB, an emergent pollutant, was detected in these mesopelagic predators. • K. sima presents higher concentration of natural and K. breviceps of synthetic compounds. • Differences in the profile suggest niche segregation in these sympatric species. [ABSTRACT FROM AUTHOR]

Persistent organic pollutants (POPs) represent a possible hazard for the ecosystems, with adverse outcomes on wildlife and humans. POPs have always received interest from the scientific community, and they have also been subject to legal restrictions worldwide on their application and commercialization. Among the broad spectrum of POPs, per- and polyfluoroalkyl substances (PFASs) are considered emerging contaminants due to their potential effect on the ecosystem and human health. These contaminants are widely employed in countless applications, from surfactants and building materials to food packaging. On the other hand, their chemical structure gives them the ability to interact with the environment, causing possible toxic effects for humans and environment. Human biomonitoring is a necessary instrument to indagate the impact of PFASs on human health: in recent years several studies have found detectable levels of PFASs in several biological matrices in humans (blood, hair, nails, and urine). Here, we review the most recent scientific literature concerning analytical methods employed in the identification and quantification of PFASs focusing on biological matrices. It has been noted that liquid chromatography coupled with mass spectrometry is the main analytical instrumentation employed, while blood and/or serum samples are the main employed human matrices whereas the use of non-invasive matrices is still at the beginning. Various issues directly related to human metabolism of PFASs and the effective amount of PFAS absorbed from the environment still need to be investigated. [Display omitted] • Per- and Polyfluoroalkyl Substances (PFASs) occurrence and human biomonitoring. • PFASs identification and quantification in biological matrices. • Extraction, clean-up procedures, and instrumental conditions for PFASs analysis. [ABSTRACT FROM AUTHOR]

Climate change and pollution are increasingly important stress factors for life on Earth. Dispersal of poly- and perfluoroalkyl substances (PFAS) are causing worldwide contamination of soils and water tables. PFAS are partially hydrophobic and can easily bioaccumulate in living organisms, causing metabolic alterations. Different plant species can uptake large amounts of PFAS, but little is known about its consequences for the plant water relation and other physiological processes, especially in woody plants. In this study, we investigated the fractionation of PFAS bioaccumulation from roots to leaves and its effects on the conductive elements of willow plants. Additionally, we focused on the stomal opening and the phytohormonal content. For this purpose, willow cuttings were exposed to a mixture of 11 PFAS compounds and the uptake was evaluated by LC-MS/MS. Stomatal conductance was measured and the xylem vulnerability to air embolism was tested and further, the abscisic acid and salicylic acid contents were quantified using LC-MS/MS. PFAS accumulated from roots to leaves based on their chemical structure. PFAS-exposed plants showed reduced stomatal conductance, while no differences were observed in abscisic acid and salicylic acid contents. Interestingly, PFAS exposure caused a higher vulnerability to drought-induced xylem embolism in treated plants. Our study provides novel information about the PFAS effects on the xylem hydraulics, suggesting that the plant water balance may be affected by PFAS exposure. In this perspective, drought events may be more stressful for PFAS-exposed plants, thus reducing their potential for phytoremediation. [Display omitted] • PFAS accumulation in plant tissues depends on their chemical properties. • Short-chain PFAS accumulates in Salix stems. • PFAS-exposed plants have reduced stomatal conductance. • Reduced stomatal conductance is abscisic acid and salicylic acid independent. • PFAS-treated plants are more vulnerable to xylem cavitation. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to describe dietary intake and important dietary sources to pollutants as well as to identify maternal socio-economic and lifestyle factors associated with high intake during pregnancy in women residing in a Mediterranean city with heavy industrial activity., Methods: Dietary intake during pregnancy of As, InAs, Cd, MeHg, Pb, PCDD/Fs, DL-PCBs, and NDL-PCBs in 701 pregnant women participating in the longitudinal ECLIPSES study was calculated based on a 45-item food-frequency questionnaire and a database of pollutants in food of the Catalan Food Safety Agency. Details on socio-economic, lifestyle, and anthropometric variables were also collected., Results: The mean dietary intake of pollutants per day and the food group that contributed the most (%) was: 286.51 μg of As (71.27% from white fish), 4.14 μg of InAs (70.16% from cereals-tubers), 6.27 μg of Cd (47.51% from seafood), 5.00 μg of MeHg (52.88% from blue fish), 3.32 μg of Pb (30.15% from cereals-tubers), 9.93 pg of PCDD/Fs (from many food categories), 18.39 pg of DL-PCBs (59.74% from blue fish) and 181.00 ng of NDL-PCBs (44.58% from blue fish). Adjusted multivariate analysis revealed that older age was associated with high As intake, higher educational level was related to low InAs, Cd, and DL-PCBs intake, and alcohol use and smoking were linked with high Pb intake., Conclusion: The dietary intake of pollutants including As and DL-PCBs among pregnant women exceeds or almost reaches the EFSA safety threshold. These findings support the urgent need for local governments to pay special attention to this situation and develop specific prevention strategies for this vulnerable group., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)

The Victoria Land (East Antarctica) is characterized by the presence of lakes and ponds where rare water is found during the Summer months. These freshwater ecosystems are an important resource for migrating seabirds that use them and leave there their droppings and feathers, contributing to enrich the water with organic matter. Persistent organic pollutants (POPs) are long-range transported to polar regions and their detection in the Antarctic ecosystems date back to the 1960s. Most studies have been related to POP concentrations in marine environment, and terrestrial ecosystems have been poorly investigated. This study reports the concentration of PBDEs (23 congeners) and PCBs (21 among non-, mono-, di-, and ortho congeners) in lake sediment, soil and vegetation mat (community of algae, cyanobacteria, bryophites) collected close to six lakes in the Victoria Land (74°31′S-74°97′S, 165°07′E-162°51′E): Edmonson Point 14 and 15A, Carezza, Enigma, Tarn Flat 20, Inexpressible Island 10B. The ∑PBDEs averaged 0.09–0.28 ng/g and BDEs 28, 47 and 154 were higher in mat and soils, while BDEs 183 and 47 in sediment samples. PCBs ranged <0.003–0.807 ng/g and congeners nos. 114, 138, and 187 were the most abundant. In addition, TEQs were derived for the non-and mono- ortho PCBs detected and values were very low in each matrix (0.010 pg/g in the soil, 0.012 pg/g in sediment and mat). The long-range atmospheric transport can be confirmed as the most important POP source in Antarctica, although the scientific stations and seabird colonies may be potential local sources and contribute to contaminant release. Image 1 • Antarctic terrestrial and freshwater ecosystems are vulnerable to human impact. • Long range transport is responsible for dispersing POPs in Antarctica. • Scientific stations, field camps, seabird colony are local PBDE sources. • PCBs and PBDEs in the Victoria Land are very low and among the lowest worldwide. • Specific orography and weather conditions help sinking POPs. [ABSTRACT FROM AUTHOR]

The country of Lebanon banned organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in 1982 and 1997, respectively, and adopted the Stockholm Convention on persistent organic pollutants (POPs) in 2003. Compliance with the Stockholm Convention began immediately, and research related to POPs in Lebanon had already been completed. A National Implementation Plan for POPs was formulated and updated several times, and includes a national inventory of PCBs that were mainly detected in insulating oils and equipment in power stations. High levels of PCBs have also been detected in sediments from the Port of Tripoli, the second major sea port in Lebanon. High levels of OCPs, which are illegally smuggled into Lebanon and improperly handled and used by farmers, have been detected in underground and surface waters for many years. There have also been human biomonitoring studies of PCBs and OCPs; for example, in 1999, measurable amounts of DDE were found in breast milk, and a 2018 study reported measurable amounts of PCBs and OCPs in human serum. While these levels were well below concentrations observed in other countries, they were slightly higher than the levels observed by the National Health and Nutrition Examination Survey (NHANES). This review provides an overview of the available PCB and OCP data from Lebanon between 1999 and 2017. In total, 12 studies of PCBs and OCPs in environmental samples, human serum samples, and human milk samples are included in this review, and the results of these studies are compared in terms of geography and chronology. • We collected data from 12 studies of PCBs and OCPs levels in Lebanon. • Akkar groundwater and Tripoli sediments have recorded high OCPs and PCBs levels. • Lebanese soil studied at national level showed acceptable levels of DDT residues. • A biomonitoring study in Beirut reported normal levels of PCBs and OCPs. [ABSTRACT FROM AUTHOR]

The epigenome may be an important interface between exposure to environmental contaminants and adverse outcome on human health. Many environmental pollutants deregulate gene expression and promote diseases by modulating the epigenome. Adverse epigenetic responses have been widely used for risk assessment of chemical substances. Various pollutants, including trace elements and persistent organic pollutants, have been detected frequently in the environment. Epigenetic toxicity of environmental matrices including water, air, soil, and food cannot be ignored. This review provides a comprehensive overview of epigenetic effects of pollutants and environmental matrices. We start with an overview of the mechanisms of epigenetic regulation and the effects of several types of environmental pollutants (trace elements, persistent organic pollutants, endocrine disrupting chemicals, and volatile organic pollutants) on epigenetic modulation. We then discuss the epigenetic responses to environmental water, air, and soil based on in vivo and in vitro assays. Finally, we discuss recommendations to promote the incorporation of epigenotoxicity into contamination screening and health risk assessment. Image 1097 • Integrate review of epigenetic profiles of environmental exposure. • Epigenetic markers as linkage between pollutants exposure and adverse outcomes. • Progress of epigenetic modulations as risk assessment indicators on various matrices. • Epigenetic responses incorporated into epigenotoxicant screening and risk assessment. [ABSTRACT FROM AUTHOR]

Abstract A multitude of cancer types, including breast, testicular, liver and colorectal cancer, have associations with exposure to Persistent Organic Pollutants (POPs). The present study aimed to investigate whether a mixture of POPs could affect intestinal tumorigenesis in the A/J Min/+ mouse, a model for human colorectal cancer (CRC). Pollutants were selected for their presence in Scandinavian food products and the mixture was designed based on defined human estimated daily intake levels. Mice were exposed through the diet, at control, low and high mixture concentrations, for 10 weeks. In a separate experiment, mice also received one subcutaneous injection of Azoxymethane (AOM) to explore whether this carcinogenic compound influenced the effect of the POPs. Intestinal tumorigenesis was examined by surface microscopy and histopathology. Moderate and dose-dependent increases in tumorigenesis were observed after dietary POP exposure. The AOM treatment alone stimulated the growth of colonic lesions, but did not increase the formation of new lesions. Combined AOM treatment and POP exposure demonstrated a synergistic effect on lesion formation in the colon, and to a lesser extent in the small intestine. This synergy was also evident by an increased number of malignant colonic tumors (carcinomas). In conclusion, the study shows that a mixture of POPs interacted synergistically with a known carcinogen (AOM), causing increased intestinal tumorigenesis in the A/J Min/+ mouse model. Highlights • Can a mixture of POPs affect intestinal tumorigenesis in the A/J Min/+ mouse? • Mice were exposed to POPs through the diet and received an injection of Azoxymethane. • Results show an increased intestinal tumorigenesis in the A/J Min/+ mouse model. [ABSTRACT FROM AUTHOR]

The aim of this study was to determine the concentration of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in marine sediments of a natural marine protected area (NMPA), Veracruz Reef System (VRS), in the Gulf of Mexico (GoM). This NMPA represents one of the first coastal sites with port activity in Mexico, which causes a range of human activities that require adequate planning so as not to impact and destroy this marine protected area; In this sense, this work represents the first effort aimed at diagnosing the presence of organochlorine contaminants in reef sediments from the mainland, both from the adjacent port area and from more distant regions with dominant agricultural activities that ultimately affect this NMPA. Content of organic matter (OM), carbonates and grain-size composition were determined to investigate their influence on compounds distribution in the sediment through multivariate analysis. The potential risk represented by organochlorines concentrations was evaluated taking as reference Sediment Quality Guidelines (SQGs). Levels of ∑PCBs, ∑DDTs, ∑HCHs and ∑Cyclodienes ranged from 11.59 to 29.79, < 0.01 to 34.11, 22.10 to 102.80, and 17.21–104.45 ng g−1 dry weight (DW), respectively. The statistical analysis revealed that the content of mud and organic matter were the parameters that might influence PCBs distribution in the sediment while OCPs could be influenced by sand and carbonate. The theoretical risk assessment estimated with the results obtained showed that concentrations of lindane, endrin, dieldrin and p,p'- DDT could have an adverse effect on the reef benthic community and continued monitoring is required. The data obtained on the organochlorine contaminants (OCs) considered in this work will contribute to support the strategies proposed by the Mexican federal government entity to continue with the conservation and surveillance of this NMPA and thereby guarantee the least impact derived mainly from port and related agricultural activities. [Display omitted] • Cyclodienes and HCHs were the most important organochlorine pesticides in the sediments of Veracruz Reef System, Gulf of Mexico. • PCBs recorded higher concentrations compared to other studies in Latin America. • The reefs of the northern zone of the VRS were the most affected by the load of organochlorine pollutants. • PCBs distribution could be influenced by mud and organic matter content while OCPs were more associated with carbonates and sands. • γ-HCH, endrin, dieldrin and p,p' -DDT were the OCPs that had higher estimated ecotoxicological risk values for the benthic community. [ABSTRACT FROM AUTHOR]

There is a lack of simple and effective methods to quantify the fate processes of persistent organic pollutants (POPs) in bioretention systems. In this study, the fate and elimination processes of three typical 13C-labeled POPs in regularly added bioretention columns were quantified using stable carbon isotope analysis techniques. The results showed that the modified media bioretention column removed more than 90% of Pyrene, PCB169 and p,p'-DDT. Media adsorption was the dominant removal mechanism for the reduction of the three exogenous organic compounds (59.1–71.8% of the input) although plant uptake (5.9–18.0%) was also important. Mineralization was effective in degrading pyrene (13.1%) but had a very limited effect on p,p'-DDT and PCB169 removal (<2.0%), the reason for which may be related to the aerobic conditions of the filter column. Volatilization was relatively weak and negligible (<1.5%). The presence of heavy metals inhibited the removal of POPs to some extent: media adsorption, mineralization and plant uptake were reduced by 4.3–6.4%, 1.8–8.3% and 1.5–3.6% respectively. This study suggests that bioretention systems are an effective measure for the sustainable removal of POPs from stormwater and that heavy metals can inhibit the overall performance of the system. Stable carbon isotope analysis techniques can help to investigate the migration and transformation of POPs in bioretention systems. [Display omitted] • The fate process of three typical POPs in bioretention column was quantified with stable carbon isotopes. • Media adsorption and plant uptake were the dominant removal mechanisms for the reduction of the exogenous organic pollutants in bioretention. • The accumulation of heavy metals in bioretention column had an inhibitory effect on the removal of POPs. • Bioretention was a viable solution for sustainable typical POPs removal from stormwater. [ABSTRACT FROM AUTHOR]

In this study, we examined associations between serum concentrations of 35 polychlorinated biphenyl (PCB) congeners, pesticides, and indicators of thyroid function in participants of the Anniston Community Health Survey (ACHS). Study subjects lived in the vicinity of a former PCB production facility and had PCB concentrations 2 to 3 times higher than similar age and race groups from the general population. We investigated associations among serum levels of thyroid hormones (thyroxin [T4], free thyroxin [fT4], triiodothyronine [T3], thyroid stimulation hormone [TSH]) and auto-antibodies (thyroglobulin antibody [TgAb] or thyroperoxidase antibody [TPOAb]) and combined indicators of thyroid function with the sum of PCBs, varying PCB groups, individual PCB congeners, and 8 pesticides. Logistic and linear regression models were adjusted for log10 transformed total lipids, age, sex, ethnicity, BMI, smoking, and family history of thyroid disease. We also performed analyses stratified by ethnicity and sex. Linear regression showed inverse associations between TT3 and thyroid-like PCBs (sum of PCBs 28, 52, 74, 101, 105, and 118; p = .0004), two pesticides (hexachlorobenzene, and pp’-DDE), and individual congeners (PCBs 74, 105). Null associations were observed between PCBs, pesticides, TSH, TT4, and fT4. Logistic regression analyses did not provide support for TT3 findings and found no association with other thyroid hormones, antibodies, or combined indicator of thyroid function. These results suggest there is little evidence that these chemicals have any major clinical effect on thyroid function in this highly PCB exposed population. [ABSTRACT FROM AUTHOR]

The large surface area of Lake Victoria (about 68,800 km 2 ) makes it vulnerable to high atmospheric deposition of chemical pollutants. We present measurements of polychlorinated biphenyls (PCBs) from the lake's atmospheric environment. High volume air (24 h) samples were collected within the northern Lake Victoria watershed in Uganda over two periods; 1999–2004 [at Kakira (KAK) and Entebbe (EBB)] and 2008–2010 (at EBB only). Precipitation samples were also collected monthly during the 2008–2010 period at EBB. Analysis for PCBs was done using GC-μECD in a dual column approach. The ranges of ΣPCB concentrations in the KAK air samples were 154–462 pg m −3 (KAK 1999–2000), 26.7–226 pg m −3 (KAK 2003–2004), 27.0–186 pg m −3 (EBB 2003), 46.8–174 pg m −3 (EBB 2004), 19.2–128 pg m −3 (EBB 2008), 45.8–237 pg m −3 (EBB 2009) and 65.6–244 pg m −3 (EBB 2010). The di-, tri-, tetra- and penta-PCBs were predominant in air sample sets while the tetra- and penta-PCBs were predominant in precipitation samples. The mean flux of ΣPCBs in the precipitation samples was 26.9 ng m −2 (range of 14.8–41.5 and median of 27.5). Concentrations at EBB were lower than those reported elsewhere for urban sites in the East and Central African region. Multivariate analysis and analysis of air mass movements suggested influence of combustion sources on the PCB profiles from the region, especially, from the major East African urbanized regions. [ABSTRACT FROM AUTHOR]

Metal smelting processes are important sources of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). The present work aims to clarify the formation characteristics of PCDD/Fs by heterogeneous mechanisms on fly ash from typical multiple secondary aluminum (SAl), secondary lead (SPb) smelting, and iron ore sintering (SNT) sources in China. The formation characteristics of PCDD/Fs on fly ash were studied in the temperature range 250–450 °C for 10–150 min. Substantial thermochemical formation of PCDD/Fs on SAl and SNT ash was observed. The maximum increase of PCDD/F concentrations under 350 °C for 30 min was 604 times greater than the initial concentration in SAl ash. The concentration of PCDD/Fs was 77 times greater than that of SNT fly ash under 350 °C for 30 min. However, the maximum increase of PCDD/F concentrations was less than 8 times that in raw SPb ash under 350 °C. Contents of total organic carbon (TOC), Cu, Al, Zn and Cl, which are widely recognized as important elements for promoting PCDD/F formation, were obviously higher in SAl and SNT ash than in SPb ash. This may explain the greater observed formation times of PCDD/Fs on SAl and SNT ash than that on SPb ash. It was found that several congeners tended to form at higher temperatures than those for SAl ash. Activation energy calculation according to the Arrhenius equations could explain the dominant formation of those congeners at much higher temperatures on SAl ash. [ABSTRACT FROM AUTHOR]

Perfluorooctane sulfonate (PFOS) was widely used in industrial applications before it was listed as a persistent organic pollutant by the Conference of the Parties in the Stockholm Convention in 2009. Although the potential toxicity of PFOS has been studied, its toxic mechanisms remain largely undefined. Here, we investigated novel hub genes and pathways affected by PFOS to gain new conceptions of the toxic mechanisms of PFOS. Reduced body weight gain and abnormal ultra-structures in the liver and kidney tissues were spotted in PFOS-exposed rats, indicating successful establishment of the PFOS-exposed rat model. The transcriptomic alterations of blood samples upon PFOS exposure were analysed using RNA-Seq. GO analysis indicates that the differentially expressed gene-enriched GO terms are related to metabolism, cellular processes, and biological regulation. Kyoto encyclopaedia of gene and genomes (KEGG) and gene set enrichment analysis (GSEA) were conducted to identify six key pathways: spliceosome, B cell receptor signalling pathway, acute myeloid leukaemia, protein processing in the endoplasmic reticulum, NF-kappa B signalling pathway, and Fc gamma R-mediated phagocytosis. The top 10 hub genes were screened from a protein–protein interaction network and verified via quantitative real-time polymerase chain reaction. The overall pathway network and hub genes may provide new insights into the toxic mechanisms of PFOS exposure states. [Display omitted] • PFOS-exposed rat model successfully established. • Transcriptomic alterations of rats upon PFOS exposure analysed using RNA-seq. • Six pathways identified as potential toxic mechanisms of PFOS. • Ten hub genes screened as key genes of PFOS toxicity. • The immune system of PFOS-exposed rats significantly affected by PFOS exposure. [ABSTRACT FROM AUTHOR]

Bacterial evolution has resulted in the appearance of several Sphingomonadacea strains that gained the ability to metabolize hexachlorocyclohexanes (HCHs). HCHs have been widely used as pesticides but were banned under the Stockholm Convention on persistent organic pollutants (POPs) in 2009. Here we present evidence for bacterial transformation reactions of hexabromocyclododecanes (HBCDs), which are structurally related to HCHs. HBCDs were used as flame retardants. They are now also considered as POPs and their production and use is restricted since 2013. Racemic α-, β-, and γ-HBCDs and their mixture were exposed to Sphingobium chinhatense IP26 in resting cell assays in parallel to β-HCH. All HBCD stereoisomers were converted with (−)β-HBCD being the best and both α-HBCD enantiomers the poorest substrates. HBCD conversion rates were 27–430 times slower than that of β-HCH. Three generations of hydroxylated transformation products were observed, 7 pentabromocyclododecanol isomers (PeBCD-ols), 11 tetrabromocyclododecadiols (TeBCD-diols) and 3 tribromocyclododecatriols (TrBCD-triols). The conversion of (+)α-, (−)β- and (−)γ-HBCD was faster than those of their enantiomers. Therefore the respective enantiomeric excess increased to 3 ± 1%, 36 ± 1% and 6 ± 2% during 48 h of bacterial exposure. PeBCD-ols appeared first, followed by TeBCD-diols and TrBCD-triols indicating stepwise hydrolytic dehalogenation reactions. In conclusion, severe HCH pollution at geographically distinct dumpsites triggered bacterial evolution to express enzymes transforming such compounds. We used S. chinhatense IP26 bacteria to transform structurally related HBCDs, also regulated under the Stockholm Convention. Such bacteria might be useful for bioremediation but the toxicity of the numerous transformation products observed must be assessed in advance. [ABSTRACT FROM AUTHOR]

Co-incineration of sewage sludge in cement kilns can be used for its disposal. In the present study, samples were collected from three cement production runs where sewage sludge and other wastes (e.g. municipal solid waste, waste acid and wet sewage sludge) were co-processed. The samples were analyzed for polychlorinated biphenyls (PCBs). The dioxin-like (dl)-PCB concentrations in the stack gases from run 1, 2, and 3 were 344.6, 548.7, and 104.3 pg m −3 , respectively. The toxic equivalency (TEQs) values for runs 1, 2, and 3 were 5.6, 8.9, and 0.7 pg TEQ Nm −3 , respectively. Calculation of net emissions for the three runs indicated that the co-incineration of other waste in addition to sewage sludge in cement kilns would not increase emission of the dl-PCBs. PCB concentrations in samples from the suspension boiler and humidifier tower, kiln-end bag filter, and cyclone preheater were much higher than those in samples from the kiln head area, indicating that these stages will be important for controlling PCB formation. Chlorinated biphenyl (CB)-77, CB-105 and CB-118 were the major dl-PCB congeners, CB-52, CB-101 were the major indicator PCB congeners, and tetra-CB to hexa-CB were the major homologues for the total input or output materials. [ABSTRACT FROM AUTHOR]

The Nanfei River is by many measures the most heavily polluted tributary to Lake Chaohu. In this study, the temporal occurrence and sources of four classes of persistent organic pollutants (POPs), including polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), in suspended particulate matter (SPM) from the river mouth were investigated monthly during 2014. Results show that concentrations of all four POPs in SPM were higher than those in the sediment of Lake Chaohu. PBDEs (26.7 ng g −1 dry weight (dw)) were originated mainly from commercial deca-BDE mixtures. PCB concentrations (1.336 ng g −1 dw) were lower than those of sediments in many other water bodies worldwide. PAHs (2597 ng g −1 dw) and OCPs (57.38 ng g −1 dw) were the most common POPs. PAHs mainly had high molecular weights and originated from pyrolytic sources, with a small proportion of petrogenic origin. The predominant OCPs were DDTs, heptachlorepoxides, dieldrin, hexachlorocyclohexanes, hexachlorobenzene, and chlordanes. Most OCPs originated from historical use, except lindane. Generally, of all the POPs studied, those of primary ecological concern should be acenaphthene, fluorene, DDTs, and chlordanes. Higher concentrations of POPs were detected during winter and spring than in summer and autumn, probably because of the high river flow during the rainy season. The high concentration of POPs in the riverine SPM and the fractionation of POPs in the water and SPM of the river should be a focal point in the future study of Lake Chaohu. [ABSTRACT FROM AUTHOR]

Persistent organic pollutants (POPs) are widespread compounds that accumulating in polar regions canalise through trophic webs. Although several dozens of studies have been carried out in the last decades, the information is generally scattered across a large number of literature sources. This does not allow an efficient synthesis and constraints our understanding on how address future monitoring plans and environmental conservation strategies on the Polar Regions with respect to POPs. Thus, here, we present the outcome of a systematic map (SM) to scope, screen and chart evidences from literature dealing with POPs in Polar regions. The SMs strive to produce rigorous guidelines and have recently been proposed as useful and effective tools to summarise growing bodies of research that seek to reduce bias and increase reliability, particularly in the case of high priority and controversial topics. Our SM was based on 125 polar studies, focussing on the most studied target species among those listed in the International Union for Conservation of Nature's Red List (IUCN Red List). To facilitate analysis of evidence, the studies were classified into Accumulation Monitoring (accounting for POP monitoring through sub-organismal, functional and population levels) and Food Web Monitoring approaches (accounting for contaminants monitoring through food webs). Our SM allowed us to assess and visualise, a set of both knowledge gaps and gluts and lastly a list was provided to address future research on POPs in Polar Regions. [ABSTRACT FROM AUTHOR]

A sampling campaign was carried out to assess the impact of the oil field activities on the concentrations of polychlorinated dibenzo- p -dioxins, polychlorinated dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in ambient air at Umm Al-Aish oil field in northern Kuwait. Sixteen samples were collected from March 2014 to January 2015. The concentrations of ΣPCDD/Fs were relatively high (33.6–586 fg I-TEQ/m 3 ; median: 94.7 fg I-TEQ/m 3 ; 31.2 to 516 fg WHO-TEQ 2005 /m 3 ; median: 83.7 fg WHO-TEQ 2005 /m 3 ) compared to those of dl-PCBs (3.9–36.8 WHO-TEQ 2005 /m 3 ; median 9.9 WHO-TEQ 2005 /m 3 ). A unique PCDD/F profile that was not previously reported was found. Further investigations should be conducted to establish whether the dioxin profile found in this study is specific for the desulfurization facility located in the study area or from oil flaring in the oil fields located upstream of the study area. The findings suggest that the oil field activities have a significant impact on the PCDD/F concentration in ambient air but a low or negligible influence on dl-PCBs’ levels. [ABSTRACT FROM AUTHOR]

Persistent organic pollutants (POPs) are distributed globally and are associated with adverse health effects in humans. A study combining gas chromatography-mass spectrometry (GC-MS), high resolution mass spectrometry (UPLC-QTof-MS) and chemometrics for the analysis of adult human serum samples was undertaken. Levels of serum POPs found were in the low range of what has been reported in similar populations across Europe (median 33.84 p, p′-DDE, 3.02 HCB, 83.55 β-HCH, 246.62 PCBs ng/g lipids). Results indicated that compounds concentrations were significantly different between the two groups of POPs exposure (high vs low) and classes (DDE, β-HCH, HCB, PCBs). Using orthogonal partial last-squares discriminant analysis (OPLS-DA), multivariate models were created for both modes of acquisition and POPs classes, explaining the maximum amount of variation between sample groups (positive mode R2 = 98–90%; Q2 = 94–75%; root mean squared error of validation (RMSEV) = 12–20%: negative mode R2 = 98–91%; Q2 = 94–81%; root mean squared error of validation (RMSEV) = 10−19%. In the serum samples analyzed, a total 3076 and 3121 ions of interest were detected in positive and negative mode respectively. Of these, 40 were found to be significantly different (p < 0.05) between exposure levels. Sphingolipids and Glycerophospholipids lipids families were identified and found significantly (p < 0.05) different between high and low POPs exposure levels. This study has shown that the elucidation of metabolomic fingerprints may have the potential to be classified as biomarkers of POPs exposure. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the levels of persistent organic pollutants (POPs) including polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in ship ballast sediments. The ballast sediment samples were collected from six merchant ships docked in 2015 in Jiangyin City, China. Ballast sediments represent a potential vector for the transport of POPs and invasive species between marine environments. An attempt was also made to determine the sources of these compounds in the ballast sediment. The results indicated ballast sediments generally contain greater amounts of BDE-209 and comparable amounts of PAHs, PBDEs (exclusive of BDE-209) and PCBs compared to those in marine surface sediments. Based on the sediment quality guidelines, PAHs and PCBs in ballast sediments were estimated to have median or high potential of posing ecological risks, respectively, to marine life if ballast sediments were disposed without specific treatment. POPs in ballast sediments were derived from multiple sources with atmospheric deposition being an important origin. Ship activities including diesel exhaust and illegal oil sewage discharge were considerable contributors of certain individual POPs to ballast sediments. Our study is important because it represents the first report on levels, health risk assessment and source apportionments of POPs in ballast sediments and is a first step in the implementation of specific ballast sediment management measures. [ABSTRACT FROM AUTHOR]

Persistent organic pollutants in human milk (HM) at high levels are considered to be detrimental to the breastfed infant. To determine the pesticide concentration in HM, a pilot cross-sectional study of 40 Western Australian (WA) women was carried out. Gas chromatography-tandem mass spectrometry (GC-MS/MS) with a validated QuEChERS was used for the analysis of 88 pesticides in HM. p,p′- dichlorodiphenyldichloroethylene ( p,p′ -DDE) with a mean concentration of 62.8 ± 54.5 ng/g fat was found, whereas other organochlorines, organophosphates, carbamates and pyrethroids were not detected in HM. Overall, no association was observed between HM p,p′ -DDE concentrations and maternal age, parity, body mass index and percentage fat mass. Furthermore, for the first time no significant association was found between p,p′ -DDE concentrations in HM and infant growth outcomes such as weight, length, head circumference and percentage fat mass. The calculated daily intake was significantly different to the estimated daily intake of total DDTs and was well below the guideline proposed by WHO. The DDTs levels in WA have also significantly decreased by 42 - fold since the 1970s and are currently the lowest in Australia. [ABSTRACT FROM AUTHOR]

This is the first research that extensively compiles all the available scientific literature on the presence of trace metals (TMs), persistent organic pollutants (POPs), and plastic debris in Chondrichthyan species inhabiting South America (including the Atlantic and Pacific Oceans), providing an insight into Chondrichthyans as bioindicators of pollutants as well as the impacts of pollutant exposure on the organisms. Seventy-three studies were published in South America between 1986 and 2022. While 68.5% focused on TMs, 17.8% on POPs, and 9.6% on plastic debris. Brazil and Argentina were at the top in terms of the number of publications; however, there is an absence of information regarding pollutants for Chondrichthyans in Venezuela, Guyana, and French Guiana. Of the 65 Chondrichthyan species reported, 98.5% belong to the Elasmobranch group, and 1.5% from the Holocephalans. Most studies focused on Chondrichthyans of economic importance, and the most analyzed organs were the muscle and liver. There is a lack of studies on Chondrichthyan species with low economic value and critical conservation status. Due to their ecological relevance, distribution, accessibility, high trophic position, capacity to accumulate high levels of pollutants, and the number of studies published, Prionace glauca and Mustelus schmitii seem to be adequate to serve as bioindicators. For TMs, POPs, and plastic debris there is a lack of studies focusing on the pollutant levels as well as their effect on Chondrichthyans. Future research reporting TMs, POPs, and plastic debris occurrences in Chondrichthyan species are required in order to increase the scarce databases about pollutants in this group, with a clear need for further research on the responses of chondrichthyans to pollutants, as well as making inferences about the potential risks to the ecosystems and human health. • There is an important knowledge gap about the possible effects of pollutants on Chondrichthyan's health in South America. • The majority of South American regions have received very little or no attention regarding pollutants on Chondrichthyans. • Prionace glauca and Mustelus schmitii have the potential to serve as good sentinel species for oceans health monitoring. • More than 20% of the studies, reported contamination levels above recommended safety limits for Human consumption. [ABSTRACT FROM AUTHOR]

Exposure to per- and polyfluoroalkyl substances (PFAS) through the environment can lead to harmful health outcomes and the development of disease. However, little is known about how PFAS impact underlying biology that contributes to these adverse health effects. The metabolome represents the end product of cellular processes and has been used previously to understand physiological changes that lead to disease. In this study, we investigated whether exposure to PFAS was associated with the global, untargeted metabolome. In a cohort of 459 pregnant mothers and 401 children, we quantified plasma concentrations of six individual PFAS- PFOA, PFOS, PFHXS, PFDEA, and PFNA- and performed plasma metabolomic profiling by UPLC-MS. In adjusted linear regression analysis, we found associations between plasma PFAS and perturbations in lipid and amino acid metabolites in both mothers and children. In mothers, metabolites of 19 lipid pathways and 8 amino acid pathways were significantly associated with PFAS exposure at an FDR<0.05 threshold; in children, metabolites of 28 lipid pathways and 10 amino acid pathways exhibited significant associations at FDR<0.05 with PFAS exposure. Our investigation found that metabolites of the Sphingomyelin, Lysophospholipid, Long Chain Polyunsaturated Fatty Acid (n3 and n6), Fatty Acid- Dicarboxylate, and Urea Cycle showed the most significant associations with PFAS, suggesting these may be particular pathways of interest in the physiological response to PFAS. To our knowledge, this is the first study to characterize associations between the global metabolome and PFAS across multiple periods in the life course to understand impacts on underlying biology, and the findings presented here are relevant in understanding how PFAS disrupt normal biological function and may ultimately give rise to harmful health effects. [Display omitted] • Age- and exposure-dependent trends were observed in metabolic perturbations to PFAS. • Five lipid pathways were consistently altered across mothers and offspring. • Seven lipid pathways differed in direction of effect between mothers and offspring. • Amino acid metabolism pathways were consistently increased in mothers and children. [ABSTRACT FROM AUTHOR]

With the advent of the industrial revolution, the accumulation of persistent organic pollutants (POPs) in the environment has become ubiquitous. POPs are halogen-containing organic molecules that accumulate, and remain in the environment for a long time, thus causing toxic effects in living organisms. POPs exhibit a high affinity towards biological macromolecules such as nucleic acids, proteins and lipids, causing genotoxicity and impairment of homeostasis in living organisms. Proteins are essential members of the biological assembly, as they stipulate all necessary processes for the survival of an organism. Owing to their stereochemical features, POPs and their metabolites form energetically favourable complexes with proteins, as supported by biological and dose-dependent toxicological studies. Although individual studies have reported the biological aspects of protein-POP interactions, no comprehensive study summarizing the structural mechanisms, thermodynamics and kinetics of protein-POP complexes is available. The current review identifies and classifies protein-POP interaction according to the structural and functional basis of proteins into five major protein targets, including digestive and other enzymes, serum proteins, transcription factors, transporters, and G-protein coupled receptors. Further, analysis detailing the molecular interactions and structural mechanism evidenced that H-bonds, van der Waals, and hydrophobic interactions essentially mediate the formation of protein-POP complexes. Moreover, interaction of POPs alters the protein conformation through kinetic and thermodynamic processes like competitive inhibition and allostery to modulate the cellular signalling processes, resulting in various pathological conditions such as cancers and inflammations. In summary, the review provides a comprehensive insight into the critical structural/molecular aspects of protein-POP interactions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Pentachlorophenol (PCP) is a toxic compound which is widely used as a wood preservative product and general biocide. It is persistent in the environment and has been classified as a persistent organic pollutant to be reclaimed in many countries. Fungal bioremediation is an emerging approach to rehabilitating areas fouled by recalcitrant xenobiotics. In the present study, we isolated two fungal strains from an artificially PCP-contaminated soil during a long-term bioremediation study and evaluated their potential as bioremediation agents in depletion and detoxification of PCP in soil microcosms. The two fungal strains were identified as: Byssochlamys nivea (Westling, 1909) and Scopulariopsis brumptii (Salvanet-Duval, 1935). PCP removal and toxicity were examined during 28 days of incubation. Bioaugmented microcosms revealed a 60% and 62% PCP removal by B. nivea and S. brumptii , respectively. Co-inoculation of B. nivea and S. brumptii showed a synergetic effect on PCP removal resulting in 95% and 80% PCP decrease when initial concentrations were 12.5 and 25 mg kg −1 , respectively. Detoxification in bioaugmented soil and the efficient role of fungi in the rehabilitation of PCP contaminated soil were experimentally proven by toxicity assays. A decrease in inhibition of bioluminescence of Escherichia coli HB101 pUCD607 and an increase of germination index of mustard ( Brassica alba ) seeds were observed in the decontaminated soils. [ABSTRACT FROM AUTHOR]

Antarctica offers a good opportunity to investigate planetary-scale pollution and climate change, and provides baseline values for contaminants such as Trace Elements (TEs) and Persistent Organic Pollutants (POPs). Literature data on contaminant levels in the Antarctic environment indicate that long-range atmospheric transport is the primary pathway by which pollutants from surrounding continents are carried to this pristine environment. However, local contamination sources represented by the scientific stations are also not negligible. Climate change and global warming are altering the global budget of anthropogenic contaminants and their monitoring in Antarctica ecosystems is very important to protect the global environment. In this work, eighty specimens of Adamussium colbecki (Smith, 1902), a benthic Antarctic scallop, collected from 1996 to 2009 and stored in the Antarctic Environmental Specimen Bank, were analyzed to quantify TEs and POPs, including polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs) and polycyclic aromatic hydrocarbons (PAHs). Metals concentrations were not affected by anthropogenic contributions, highlighting a natural accumulation with the age of the organism. Similarly, no temporal trend was found for PCNs, PCBs and PAHs. However, specimens collected during the summer 1997–98 showed enhanced concentration levels of PCBs and PAHs that could refer to a local anthropogenic source of contamination. [ABSTRACT FROM AUTHOR]