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N-nitrosodimethylamine (NDMA), a probable carcinogenic disinfection by-product, can be formed with high molar yields following chloramination of ranitidine (RNTD), a histamine H 2 -receptor antagonist. Although RNTD and some of its transformation products (TPs) have been studied under chlorination and photo-irradiation, the relationship between RNTD TPs and NDMA formation potential (NDMA-FP) remaining after those processes is still unclear. This study investigated the effects of chlorination and/or photo-irradiation on NDMA-FP derived from RNTD, simulating an urban water environment receiving treated wastewater. After chlorination and/or photo-irradiation of RNTD, ten TPs including five new ones were identified by liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTof-MS). In addition, important RNTD TPs responsible for NDMA-FP (e.g., chlorinated and hydroxylated RNTD: TP-364) were also confirmed by the relationship between detected peak area and NDMA-FP. The results showed that NDMA-FP remained due to the presence of RNTD TPs, although RNTD itself was significantly removed by chlorination and/or photo-irradiation. TP-364 was only formed by chlorination of RNTD and could not be removed by photo-irradiation. TP-314 (a stereoisomer of RNTD), -299, and -286, which were mainly formed by photo-irradiation of RNTD but not by photo-irradiation after chlorination, had strong positive correlations with NDMA-FP (R 2  > 0.90; F-test, P < 0.01)., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

We investigated the effects of the inclusion of biological activated carbon (BAC) on membrane fouling in combined process of ozonation, coagulation and ceramic membrane filtration (O 3  + PACl + CMF) for treating secondary effluent. Inclusion of BAC between ozonation and coagulation reduced membrane permeability. The normalized flux decreased to 90% of the initial value after 305 h of operation in O 3  + PACl + CMF, while it decreased to 20% in combined process of ozonation, BAC, coagulation and ceramic membrane filtration. BAC not only decreased residual ozone that is helpful to mitigate ceramic membrane fouling, but also released microorganisms. In addition, BAC doubled the integrated fluorescence intensity of soluble microbial products (SMP), which cause irreversible fouling. The SMP produced and accumulated by microorganisms on the BAC bed likely flowed into the BAC effluent with the microorganisms. The proportion of SMP in the extracted foulant increased from 25% without BAC to 31% with BAC. Moreover, the inclusion of BAC nearly doubled the concentration of protein in the extracted foulant to 13 g/m 2 and quadrupled that of carbohydrate to 6 g/m 2 . BAC was effective in improving the quality of ceramic membrane permeates and reducing health risk associated with formaldehyde and N-nitrosodimethylamine. However, the release of SMP from BAC accelerated membrane fouling in subsequent ceramic membrane filtration., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

A year-round monitoring survey of sewage flowing into sewage treatment plants located in urban Japan was conducted by targeting seven representative pharmaceutical components-atenolol (ATL), ciprofloxacin (CFX), clarithromycin (CTM), diclofenac (DCF), diltiazem (DTZ), disopyramide (DSP), and sulpiride (SPR)-detected in the river environment. For each of these components, two types of predicted concentration were estimated on the basis of two types of data (the shipping volume and sales volume of each component). The measured concentration of each component obtained through the survey and the two types of estimated predicted concentration of each component were then compared. The correspondence ratio between the predicted concentration estimated from the shipping volume of the component and the measured concentration (predicted concentration/measured concentration) was, for ATL, 3.1; CFX, 1.4; CTM, 1.4; DCF, 0.2; DTZ, 0.9; DSP, 11.6; and SPR, 1.1. The correspondence ratio between the predicted concentration estimated from the sales volume of the component and the measured concentration was, for ATL, 0.5; CFX, 1.1; CTM, 0.8; DCF, 0.1; DTZ, 0.2; DSP, 0.7; and SPR, 0.8. Although a generally corresponding trend was seen regardless of whether the prediction was based on shipping volume or sales volume, the predicted concentrations estimated from the shipping volumes of all components expect DSP were found, to our knowledge for the first time in Japan, to correspond better than those based on sales volumes to the measured concentrations. These findings should help to improve the prediction accuracy of concentrations of pharmaceutical components in river waters., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

We established a method for the simultaneous analysis of seven preservatives and five antimicrobials in water. These chemicals are widely used in cosmetics, and their presence in river water is of concern. We used the method to test 13 sites in Japanese rivers and streams contaminated by domestic wastewater, effluent, or industrial wastewater. 2-Phenoxyethanol (2-PE), isopropylmethylphenol, resorcinol, and triclosan were detected at most sites; the maximum concentration of 2-PE detected was 14000 ng L(-1). The results suggest that the major sources of 2-PE were cosmetics and household detergents. The ratio of methylparaben to n-propylparaben in river waters with direct wastewater drainage was similar to that in common cosmetics. This is the first research on levels of 2-PE, isopropylmethylphenol, and chlorphenesin in river water., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

In February 2011, at the peak of an influenza outbreak, we performed a comprehensive analysis of the mass balances of four anti-influenza drugs-oseltamivir (OS), oseltamivir carboxylate (OC), amantadine (AMN), and zanamivir (ZAN)-in the urban area of the Yodo River system. This area includes three main river catchments (the Katsura, Uji, and Kidzu Rivers) and is home to 12 million people, about 10% of Japan's population. Water was sampled at six main rivers and 13 tributary sites and eight sewage treatment plants (STPs). We concluded that the STP effluents were the major sources of the anti-influenza drug load in the Yodo River system (68-94% of total mass fluxes). Extended measurement throughout the Yodo River system further showed only small fluctuations of the ratio of OS to OC from 0.2 to 0.3, suggesting that OS and its metabolite are environmentally stable. The results also clearly showed the importance of reducing the levels of anti-influenza drugs in the water environment by reducing their emission at STPs., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

The occurrence of free and conjugated estrogens was examined in a survey of eleven sewage treatment plants (STPs) and their discharge water in the United Kingdom using grab sampling. The STPs included trickling filter with and without tertiary treatment, and activated sludge with tertiary treatment. For three activated sludge plants both influent and effluent samples were compared. For a further 8STPs only the effluent was examined. The estrone-3-sulphate, estradiol-3-sulphate and estriol-3-sulphate concentrations (up to 20 ng L(-1)) were typically 5-fold that of the respective free estrogen concentration in the effluents. This represents a substantial additional 'potential' estrogen load arriving in the receiving waters. Estrone-3-glucuronide was found at 9 ng L(-1), estradiol-3-glucuronide at 7 ng L(-1), and estriol-3-glucuronide at 32 ng L(-1) in sewage influent. Except on one occasion, no glucuronide conjugates could be found in the effluent. The results suggest in most cases glucuronide conjugates will be completely transformed in sewage treatment whilst sulphate conjugates will only be partially removed., (Copyright © 2010 Elsevier Ltd. All rights reserved.)

We investigated the occurrence and fate of the two antiviral drugs oseltamivir carboxylate (OC)-the active metabolite of Tamiflu-and amantadine (AMT) at three sewage treatment plants (STPs) during the 2008-2009 and 2009-2010 influenza seasons in Japan. Both compounds were detected in all samples analyzed. The concentrations in raw influents at the STPs ranged from 140 to 460 ng L(-1) OC and from 184 to 538 ng L(-1) AMT. Primary treatment gave no substantial removal of the drugs (OC, 2-9%; AMT, 7-17%). Biological nutrient-removal-based secondary treatment (anoxic-oxic-anoxic-oxic and anaerobic-anoxic-oxic) removed 20-37% of OC, whereas extended-aeration-based conventional activated sludge treatment removed <20%. STPs using primary plus biological secondary treatment removed <50% of the drugs. The incorporation of tertiary treatment by ozonation removed >90%. Ozonation after secondary treatment in STPs will be necessary during an influenza pandemic to reduce the risks associated with the widespread use of antiviral drugs., (Copyright (c) 2010 Elsevier Ltd. All rights reserved.)

This article describes the development of a short pre-treatment method that allows the simultaneous analysis of free estrogens (estrone, 17beta-estradiol, estriol and 17 alpha-ethynylestradiol) and their sulphate and glucuronide conjugated forms. For a range of matrices, from sewage effluent to river water, the developed methodology based on solid-phase extraction and fractionation technique with ultra-performance liquid chromatography system showed effective separation of the targeted estrogens. The detection limits of this method ranged from 0.2 to 0.8 ng L(-1) for river water. The recoveries for river water and sewage effluent varied from 63% to 127%. The problems of matrix effects and ion suppression or enhancement were allowed quantitatively for in the analysis using standard addition. The developed method was used successfully to detect estrogens and their conjugates in both raw and treated wastewater, and river water at a location in Japan. High concentrations of the free estrogens estrone, 17beta-estradiol and estriol were found in the influent (22.6, 77.2, 64.6 ng L(-1), respectively) but only E1 was still present at a high concentration in the effluent which was reflected in the downstream river concentration. Estrone-3-sulphate was detected up to 18.0 ng L(-1) in influent water sample and 1.1 ng L(-1) in downstream water. For the sulphate conjugates, removal efficiencies varied from 35 to 88%. Glucuronide conjugates were detected only once in the sewage influent.