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Your search keyword '"Messori, Luigi"' showing total 12 results
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12 results on '"Messori, Luigi"'

1. A Fluorescent Silver(I) Carbene Complex with Anticancer Properties: Synthesis, Characterization, and Biological Studies

Author

Fabbrini, Maria Giulia, primary, Cirri, Damiano, additional, Pratesi, Alessandro, additional, Ciofi, Lorenzo, additional, Marzo, Tiziano, additional, Guerri, Annalisa, additional, Nistri, Silvia, additional, Dell'Accio, Alfonso, additional, Gamberi, Tania, additional, Severi, Mirko, additional, Bencini, Andrea, additional, and Messori, Luigi, additional

Published
2018
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6. Butyltin(IV) Benzoates: Inhibition of Thioredoxin Reductase, Tumor Cell Growth Inhibition, and Interactions with Proteins

Author

Navakoski de Oliveira, Kely, primary, Andermark, Vincent, additional, von Grafenstein, Susanne, additional, Onambele, Liliane A., additional, Dahl, Gregor, additional, Rubbiani, Riccardo, additional, Wolber, Gerhard, additional, Gabbiani, Chiara, additional, Messori, Luigi, additional, Prokop, Aram, additional, and Ott, Ingo, additional

Published
2012
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12. Anticancer ruthenium(III) complex KP1019 interferes with ATP-dependent Ca2+ translocation by sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

Author

Sadafi FZ, Massai L, Bartolommei G, Moncelli MR, Messori L, and Tadini-Buoninsegni F

Subjects
Adenosine Triphosphate chemistry, Adenosine Triphosphate metabolism, Antineoplastic Agents metabolism, Calcium chemistry, Cisplatin chemistry, Cisplatin metabolism, Coordination Complexes metabolism, Cymenes, Dimethyl Sulfoxide analogs & derivatives, Dimethyl Sulfoxide chemistry, Dimethyl Sulfoxide metabolism, Indazoles metabolism, Organometallic Compounds metabolism, Protein Binding, Ruthenium Compounds, Sarcoplasmic Reticulum Calcium-Transporting ATPases metabolism, Antineoplastic Agents chemistry, Calcium metabolism, Coordination Complexes chemistry, Indazoles chemistry, Organometallic Compounds chemistry, Sarcoplasmic Reticulum Calcium-Transporting ATPases antagonists & inhibitors
Abstract

Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA), a P-type ATPase that sustains Ca2+ transport and plays a major role in intracellular Ca2+ homeostasis, represents a therapeutic target for cancer therapy. Here, we investigated whether ruthenium-based anticancer drugs, namely KP1019 (indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)]), NAMI-A (imidazolium [trans-tetrachloro(1H-imidazole)(S-dimethylsulfoxide)ruthenate(III)]) and RAPTA-C ([Ru(η6-p-cymene)dichloro(1,3,5-triaza-7-phosphaadamantane)]), and cisplatin (cis-diammineplatinum(II) dichloride) might act as inhibitors of SERCA. Charge displacement by SERCA adsorbed on a solid-supported membrane was measured after ATP or Ca2+ concentration jumps. Our results show that KP1019, in contrast to the other metal compounds, is able to interfere with ATP-dependent translocation of Ca2+ ions. An IC50 value of 1 μM was determined for inhibition of calcium translocation by KP1019. Conversely, it appears that KP1019 does not significantly affect Ca2+ binding to the ATPase from the cytoplasmic side. Inhibition of SERCA at pharmacologically relevant concentrations may represent a crucial aspect in the overall pharmacological and toxicological profile of KP1019., (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2014
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