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Your search keyword '"A. Nebbioso"' showing total 12 results
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12 results on '"A. Nebbioso"'

1. Novel Pyridine‐Based Hydroxamates and 2′‐Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity

Author

Zwergel, Clemens, primary, Di Bello, Elisabetta, additional, Fioravanti, Rossella, additional, Conte, Mariarosaria, additional, Nebbioso, Angela, additional, Mazzone, Roberta, additional, Brosch, Gerald, additional, Mercurio, Ciro, additional, Varasi, Mario, additional, Altucci, Lucia, additional, Valente, Sergio, additional, and Mai, Antonello, additional

Published
2020
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3. Pyrrole-Based Hydroxamates and 2-Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities

Author

Maria Tardugno, Antonello Mai, Lucia Altucci, Angela Nebbioso, Mariarosaria Conte, Silvio Massa, Sergio Valente, Valente, S, Conte, M, Tardugno, M, Massa, S, Nebbioso, Angela, Altucci, Lucia, and Mai, A.

Subjects
aminoanilides, apoptosis, epigenetics, histone deacetylases, hydroxamates, inhibitors, Hydroxamic Acids, Biochemistry, Histone Deacetylases, Histones, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tubulin, Cell Line, Tumor, Drug Discovery, Humans, Protein Isoforms, Anilides, Pyrroles, Epigenetics, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, 030304 developmental biology, Pyrrole, Pharmacology, 0303 health sciences, Histone deacetylase 5, HDAC11, Histone deacetylase 2, Chemistry, HDAC10, Organic Chemistry, Recombinant Proteins, Cell biology, Histone Deacetylase Inhibitors, Apoptosis, 030220 oncology & carcinogenesis, Molecular Medicine, Histone deacetylase
Published
2009
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4. Synthesis of Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities

Author

Lucia Altucci, Vincenzo Carafa, José A. Souto, Mariarosaria Conte, Angela Nebbioso, Angel R. de Lera, Rosana Alvarez, Souto, Ja, Conte, M, Alvarez, R, Nebbioso, Angela, Carafa, V, Altucci, Lucia, and DE LERA, Ar

Subjects
G2 Phase, Apoptosis, Hydroxamic Acids, Biochemistry, S Phase, Structure-Activity Relationship, chemistry.chemical_compound, Amide, Drug Discovery, Tumor Cells, Cultured, medicine, Humans, Structure–activity relationship, p300-CBP Transcription Factors, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Vorinostat, Histone Acetyltransferases, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Cell Cycle, Organic Chemistry, HEK 293 cells, Cell Differentiation, Stereoisomerism, Histone acetyltransferase, Molecular biology, Anacardic Acids, Histone, Acetylation, Benzamides, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Cell Division, Granulocytes, medicine.drug
Abstract

A group of benzamides related to anacardic acid amide CTPB with alkyl chains of defined length were prepared by a five-step sequence starting from 2,6-dihydroxybenzoic acid, and their activities were compared with those reported for the HAT inhibitor anacardic acid (AA). The subset of 4-cyano-3-trifluoromethylphenylbenzamides with shorter chains exhibited activities similar to that of AA, as they behaved as human p300 inhibitors, induced a decrease in histone acetylation levels in immortalized HEK cells, and counteracted the action of the HDAC inhibitor SAHA in MCF7 breast cancer cells. Moreover, an analogue with the shortest alkyl chain induced significant apoptosis at 50 microM in U937 leukemia cells.

Published
2008
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6. Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death

Author

Basso, Manuela, primary, Chen, Huan Huan, additional, Tripathy, Debasmita, additional, Conte, Mariarosaria, additional, Apperley, Kim Y. P., additional, De Simone, Angela, additional, Keillor, Jeffrey W., additional, Ratan, Rajiv, additional, Nebbioso, Angela, additional, Sarno, Federica, additional, Altucci, Lucia, additional, and Milelli, Andrea, additional

Published
2018
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8. Novel Cinnamyl Hydroxyamides and 2‐Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity

Author

Valente, Sergio, primary, Tardugno, Maria, additional, Conte, Mariarosaria, additional, Cirilli, Roberto, additional, Perrone, Andrea, additional, Ragno, Rino, additional, Simeoni, Silvia, additional, Tramontano, Anna, additional, Massa, Silvio, additional, Nebbioso, Angela, additional, Miceli, Marco, additional, Franci, Gianluigi, additional, Brosch, Gerald, additional, Altucci, Lucia, additional, and Mai, Antonello, additional

Published
2011
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9. Identification of Tri‐ and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors

Author

Rotili, Dante, primary, Tarantino, Domenico, additional, Carafa, Vincenzo, additional, Lara, Ester, additional, Meade, Sarah, additional, Botta, Giorgia, additional, Nebbioso, Angela, additional, Schemies, Jörg, additional, Jung, Manfred, additional, Kazantsev, Aleksey G., additional, Esteller, Manel, additional, Fraga, Mario F., additional, Altucci, Lucia, additional, and Mai, Antonello, additional

Published
2010
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12. Synthesis and Biological Validation of Novel Synthetic Histone/Protein Methyltransferase Inhibitors

Author

Mai, Antonello, primary, Valente, Sergio, additional, Cheng, Donghang, additional, Perrone, Andrea, additional, Ragno, Rino, additional, Simeoni, Silvia, additional, Sbardella, Gianluca, additional, Brosch, Gerald, additional, Nebbioso, Angela, additional, Conte, Mariarosaria, additional, Altucci, Lucia, additional, and Bedford, Mark T., additional

Published
2007
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