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Cymoxanil (CYM) is one of the most important fungicides for various vegetables and fruits. However, its routine detection is still expensive due to high‐cost equipment. In this context, the silver nanoparticle‐based colorimetric probe was synthesized using triazole‐N‐acetamide thiazole (TAT) derivative as a stabilizer. The triazole‐N‐ acetamide thiazole (TAT) derivative functionalized silver nanoparticles (TAT‐AgNPs) were used as a probe for selective, efficient, rapid and quantitative determination of CYM in tap and river water. The characterization of TAT‐AgNPs was accomplished through UV‐visible, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Zetasizer analysis. Highly sensitive surface plasmonic resonance band at 400 nm indicated complete reduction of Ag+ by using 1 : 15 (v/v) (TAT: AgNO3). The limit of detection (LOD), which corresponds to signal‐to‐noise ratio 3, is 0.013 μmol L−1, showed a linear response as a function of CYM concentration from 1 to 100 μM. Furthermore, the probe shows good selectivity when exposed to a series of interfering pesticides. TAT‐AgNPs were also spiked with blood plasma and the effects of relevant interfering studies were evaluated. The nanosensor detects the CYM tap water and river water samples. It confirmed that nanosensor can detect CYM in biological and environmental samples. [ABSTRACT FROM AUTHOR]

The electrochemical properties of ibrutinib (IBR), a new generation smart anti‐cancer drug, one of the Bruton's tyrosine kinase (BTK) inhibitors were investigated by a voltammetric method in the anionic surfactant (sodium dodecyl sulfate, SDS) medium with the boron‐doped diamond electrode (BDDE). IBR showed an oxidation step at about +1.56 V (vs Ag/AgCl (3.0 mol L−1 KCl) by cyclic voltammetry (CV) technique in 0.1 mol L−1 H2SO4 solution. IBR was found to be irreversible and diffusion‐controlled on the surface of the BDDE with studies of scan rate. The possible electrochemical oxidation reaction of IBR with the electroactive ring (pyrazole‐pyrimidine ring) in the structure of IBR is discussed. Square wave voltammetry (SWV) was preferred as the study method due to reproducibility for the determination of IBR in pharmaceutical and urine samples. At optimal values of SWV parameters, IBR showed good linearity in the concentration range of 0.01–2.00 μg mL−1 (5.7×10−8–2.3×10−6 mol L−1) in 0.1 mol L−1 H2SO4 with 6×10−4 M SDS. The detection (LOD) and quantification (LOQ) limits for IBR were set at 0.003 μg mL−1 (6.9×10−9 mol L−1) and 0.01 μg mL−1 (2.27×10−8 mol L−1), respectively. The relative standard deviation of the intra‐day and inter‐day repeatability of the proposed method was found 2.15 and 3.76, respectively. The necessary validation parameters have also been studied, and the recovery results obtained from both pharmaceutical dosage form and human urine samples show that the developed method is accurate and precise. [ABSTRACT FROM AUTHOR]

This study explains the synthesis of cobalt‐doped dysprosium oxide nanocubes (Co‐Dy2O3 NCs) and the modification of GCE (glassy carbon electrode), for the selective and sensitive detection of riboflavin (RF). The Co‐Dy2O3 NCs were synthesized by co‐precipitation method and characterized using spectroscopic and microscopic techniques like micro‐Raman Spectroscopy, X‐ray diffraction (XRD), X‐ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FT‐IR), High‐Resolution Transmission Electron Microscopy (HRTEM), Energy‐Dispersive X‐ray Spectroscopy (EDX), and High Resolution Scanning Electron Microscopy (HRSEM). The synthesized Co‐Dy2O3 NCs were coated on the glassy carbon electrode to detect and quantify the concentration of riboflavin in aqueous and real samples. The samples were analyzed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques with three‐electrode system. The modified electrode displays two linear concentration ranges (0.5–50, 50–300 μM) with a low detection limit (LOD) of 0.094 μM and high sensitivity of 3.67 μA μM−1 cm−2. Besides, the fabricated sensor has more selectivity, great reproducibility, repeatability and good stability. Finally, the Co‐Dy2O3 NCs modified GCE based sensor was effectively applied in real sample analysis using milk and egg yolk with good recovery. [ABSTRACT FROM AUTHOR]

In an alkaline solution, mercuric oxide decorated carbon nanotube nanocomposites (HgO.CNT NCs) were manufactured utilizing an uncomplicated wet‐chemical approach. Ultra‐Violet spectroscopy (UV‐Visible), Fourier Transform Infra‐red spectroscopy (FTIR), Powder X‐ray Diffraction (XRD), X‐ray Photo‐electron Spectroscopy (XPS), and Field Emission Scanning Emission Microscopy (FESEM), X‐ray Electron Dispersive Spectroscopy (XEDS) techniques were applied to examine the HgO.CNT NCs that had been prepared. Ascorbic acid sensor was developed upon light coating of HgO.CNT NCs on polished Glassy carbon electrode (GCE) modified with nafion (Nf). Analytical performance of the selected ascorbic acid sensor was achieved such as sensitivity, Limit of quantification (LOQ), Limit of detection (LOD), Linear dynamic range (LDR), extended reliability, interference effect experimentation, and actual sample inspection using a consistent current‐voltage approach. Calibration curve of the suggested sensor was observed to be linear (R2=0.9957) throughout a broad range of ascorbic acid concentrations (100.0 pM∼100.0 mM) at a voltage of 0.8 V. The calibration curve yielded analytical parameters such as sensitivity (632.91 pAμM−1cm−2), LOQ (255.0 pM), LOD (76.50 pM), and LDR (100.0 pM ∼1.0 mM) for the proposed ascorbic acid sensor (GCE/HgO.CNT NCs/Nf). The wet‐chemical synthesis of HgO.CNT NCs is a good development of nanocomposite‐oriented sensor advancement in medical sciences with non‐enzymatic detection of biological substances. This proposed sensor applied to selective ascorbic acid detection in biological samples and obtained logical outcomes. [ABSTRACT FROM AUTHOR]

The significance of sulfasalazine (SSZ) as a therapeutic agent has garnered paramount research interest in the design and fabrication of a viable sensor for the detection of SSZ. Herein, we demonstrate a new strategy for the sensitive determination of SSZ employing single walled carbon nanotubes decorated with Fe3O4 nanoparticles sensing platform for the first time. The synthesized Fe3O4 nanoparticles and the surface morphology of the developed sensor were investigated by exerting various analytical techniques. The optimization of operational parameters was effectuated. The developed sensor exhibited pronounced electrocatalytic activity for the electro oxidation of SSZ in the dynamic detection range of 25 nM–1.5 μM manifesting noteworthy high sensitivity and phenomenal low detection limit of 18.6 μA μM−1 and 1.6 nM respectively. Apparent specificity in the presence of interferents along with remarkable stability and reproducibility were attained by the sensor. The prominence of the developed methodology was emphasized by the determination of SSZ in pharmaceutical formulations. Furthermore, the applicability of the developed electrode was established by utilizing it effectually for the first time to quantify SSZ in serum sample of patients undergoing pharmacological treatment for rheumatoid arthritis. [ABSTRACT FROM AUTHOR]

Rhodamine dye containing Isonicotinic hydrazide (RBN‐1) is synthesized for the sensing of nitro aromatics, the probe showed turn‐on fluorescence with Picric acid in co‐existence with other interfering nitro aromatics. The sensor RBN‐1 can be used for naked eye detection of picric acid with the detection limit of 37.3 nM in solution. The RBN‐1+PA complexation involves intermolecular hydrogen bonding between the pyridine N and the hydroxyl group of PA. The observed photophysical changes of RBN‐1 with Picric acid is attributed to the spirolactam ring opening. The effective sensing ability of RBN‐1 is tested in real water samples and paper strip experiments, the results are in good agreement with the pilot analysis. Rhodamine‐isonicotinic hydrazide (RBN‐1) probe establish a selective Turn‐ON fluorescent sensing towards PA both in solution and solid phase with lowest detection limit of 37.3 nM in solution. The sensor is spontaneous, provides naked eye detection to PA and more attractively, the sensor provides positive result in detection of PA in real water samples and test strips studies. [ABSTRACT FROM AUTHOR]