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Your search keyword '"Sivakumar Shanmugam"' showing total 9 results
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9 results on '"Sivakumar Shanmugam"'

1. Synthesis and Characterization of Spirooxindole β‐Ketothiolester and their Fluorescence Imaging on PC3 Cells.

Author

Sriram Babu, Seenivasagaperumal, Savitha Devi, Natarajan, Manjula Devi, Ramamoorthy, Dhiraviam Kannan, Narayanan, and Sivakumar, Shanmugam

Subjects
CELL imaging, FLUORESCENCE, CYTOTOXINS, HYDROGEN bonding, CANCER cells
Abstract

Biologically‐active near‐ultraviolet emitting spirooxindole‐pyrrolidine/pyrrolothiazole‐β‐ketothiolester have been synthesised via Chemo‐/regio‐/stereoselective manner. Excited‐state intramolecular proton transfer (ESIPT) of β‐ketothiolester exhibits excitation‐dependent emission with intermolecular hydrogen bonding ability with solvents. The emission could be tunable between 330 nm to 460 nm. Selected fluorescent compounds 4{4,2,1}, 4{12,2,2}, 5{4,2,1} and 5{12,2,2} shows cytotoxicity effect on PC3 cells, where the highest IC50 value (6 μM) was found for the probe 5{12,2,2}. The fluorescent behavior of 5{4,2,1} and 5{12,2,2} acted as an imaging molecule against cancer cells. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Metal-Free γ,δ -Unsaturated β -Ketothiolester: Solvatochromism, AIEE and Detection of Picric Acid

Author

Sivakumar Shanmugam and Seenivasagaperumal Sriram Babu

Subjects
Solvatochromism, Excited state intramolecular proton transfer, Picric acid, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Metal free, 0210 nano-technology
Published
2018
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6. A Simple and Direct Synthesis of Pentasubstituted Pyrroles via [3+4] Annulation and Their In Vitro Evaluation as Thrombolytic Agents and Cytotoxicity Studies on L929 Cells

Author

Biguvu Balachandra and Sivakumar Shanmugam

Subjects
Annulation, 010405 organic chemistry, Chemistry, Simple (abstract algebra), Thrombolytic Agent, General Chemistry, 010402 general chemistry, Cytotoxicity, 01 natural sciences, Combinatorial chemistry, In vitro, 0104 chemical sciences
Published
2018
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9. Regioselective Synthesis of Pyrrolylpyrazole as a Multifunctional Compound: Potential Antibacterial as well as Anticancer Agent

Author

Muthiah Ramakritinan, Thillaichidambaram Muneeswaran, Sivakumar Shanmugam, and Mathiyazhagan Arun Divakar

Subjects
Drug, 010405 organic chemistry, media_common.quotation_subject, Regioselectivity, General Chemistry, Pyrazole, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Pyrrole derivatives, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Cervical carcinoma, Organic chemistry, Molecule, Antibacterial activity, Pyrrole, media_common
Abstract

A regioselective synthesis of 3-pyrazolyl-4-aryl substituted pyrrole derivatives from α-aroylidineketene dithioacetals using a convenient and efficient protocol. The pyrrolylpyrazole molecules were expected to have good application in biological system consequently most of the compounds shows excellent antibacterial activity when compared with streptomycin drug. All the synthesized compounds were studied for their anticancer activity in which 5 b, 5 e, 5 g, 5 i have cytotoxic potential on cervical cancer cells at lower concentration.

Published
2016
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