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2. A New Lipid‐Droplets‐Targeted Fluorescence Probe with Dual‐Reactive Sites for Specific Detection of ClO− in Living Cells.

Author

Li, Zhao, Yang, Yuan, Yin, Pei, Yang, Zengming, Zhang, Bo, Zhang, Shengjun, Han, Bingyang, Lv, Jiawei, Dong, Fenghao, and Ma, Hengchang

Subjects
FLUORESCENCE, LIPID metabolism, CELL imaging, LIPOPHILICITY, EGG yolk
Abstract

Lipid droplets (LDs) are organelles composed of a lipid core surrounded by a phospholipid monolayer, plays an important role in a variety of physiological processes as well as diseases. In this work, TPAs‐SCH3‐2CN with an enhanced electron D‐π‐A system, is synthesized, which makes itself as an orange emission compound (Em=590 nm) and also have high polarity. It is verified that TPAs‐SCH3‐2CN is an excellent LDs‐targeted probe, and it also sensitive to the ClO− detection in vitro and in cells. Impressively, due to the high lipophilicity, TPAs‐SCH3‐2CN is able to stain the yolk lipids in zebrafish, exhibiting the potential for monitoring lipid transport and metabolism processes. [ABSTRACT FROM AUTHOR]

Published
2022
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