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A series of 4-(substituted benzylidene-amino)-2,3-dimethyl-1-phenyl- 3-pyrazoline-5-ones (3a-l) was obtained using sonochemical assisted reaction. The synthesized Schiff bases were evaluated for their antiviral, antibacterial, anticandida, DPPH scavenging and anti-tyrosinase activities in vitro. The antimicrobial screening results revealed that amongst the tested imines, compound 3l appeared to be а promising one (with a minimal inhibitory concentration 47 ug/ml). The most potent DPPH scavengers were azometines 3a and 3g. No significant inhibition on the monophenolase activity in vitro of mushroom tyrosinase was observed. [ABSTRACT FROM AUTHOR]

The emergence of a novel pandemic influenza A (H1N1) strain in 2009 is an evident mark for the unremitting risk of respiratory viral diseases. Influenza outbreaks and development of desease and could be overcome by use of vaccines and antivirals. Currently, clinically applied influenza antivirals are limited to M2 ion channel blockers (amantadine and rimantadine) and neuraminidase inhibitors (oseltamivir and zanamivir). Development of resistant viral progeny though, is one of the major challenges to antiviral chemotherapy, in general. Resistant viral mutants are described to both classes of anti-influenza antivirals, as well. Therefore, the development of new antiviral agents for influenza treatment is a hot topic and a never ending task. Combining antiviral drugs with antioxidants in severe influenza-associated complications is of great therapeutic significance. Based on the prominent antioxidant activity of hydroxycinnamic acids, herein, we report the biological activity of newly synthesized amides obtained by coupling previously synthesized N-hydroxycinnamoyl amides of fluorinated amino acids and a fragment of oseltamivir. [ABSTRACT FROM AUTHOR]