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Start Over Author "Julfakyan, Khachatur" Journal chemistry weinheim an der bergstrasse germany

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1. Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells.

Author

Croissant JG, Fatieiev Y, Julfakyan K, Lu J, Emwas AH, Anjum DH, Omar H, Tamanoi F, Zink JI, and Khashab NM

Subjects
Drug Delivery Systems, Hydrophobic and Hydrophilic Interactions, Oxamic Acid chemistry, Nanoparticles chemistry, Organosilicon Compounds chemistry, Oxamic Acid analogs & derivatives, Silicon Dioxide chemistry
Abstract

We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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