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The present study reports the presence of a β-D-fructopyranosyl-(2→1)-linked fructan in nature for the first time, with a β-D-fructofuranosyl-(2→1)-linked fructan in a mixture from Codonopsis pilosula. High-performance gel permeation chromatography (HPGPC) shows that the molecule weights of these two fructans are 2.33 and 1.31 kDa. Their structures were analyzed by 1D and 2D NMR.

A new cycloartanyl ester, named codonopilate D (1), was isolated from the roots of Codonopsis pilosula (Franch.) Nannf. The structure of compound 1 was elucidated by extensive spectroscopic analysis including UV, IR, MS, and NMR data. Compound 1 exhibited the potential of inhibiting LPS-induced NO production in RAW 264.7 cells.