1. Total Synthesis of the Octacyclopeptide Brachystemin F.
- Author
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Li, Ren-wu, Li, Wen-juan, Wu, Mao-cheng, Zhao, Qing-jie, Zou, Yan, and Hu, Hong-gang
- Subjects
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PEPTIDE synthesis , *SOLID-phase synthesis , *AMINO acids , *RING formation (Chemistry) , *CYCLIC peptides , *CHEMICAL purification , *HIGH performance liquid chromatography , *NUCLEAR magnetic resonance - Abstract
The naturally occurring octacyclopeptide brachystemin F was synthesized for the first time in the present study by a two-step solid-phase/solution strategy. All the amino acids in this study have the L-configuration. The linear octapeptide was assembled by standard Fmoc solid-phase peptide synthesis (SPPS), and subsequent cyclization was carried out by the solution method. The target compound was purified by preparative RP-HPLC, and its structure was identified by H NMR, C NMR, and MS. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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