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6 results on '"Wenbo Wu"'

3. Binary Organic Nanoparticles with Bright Aggregation-Induced Emission for Three-Photon Brain Vascular Imaging

Author

Wenbo Wu, Ke Wang, Gaixia Xu, Bin Liu, Hongji Liu, Miaozhuang Fan, Ken-Tye Yong, Xiangquan Deng, Yukun Duan, Bobo Gu, Maixian Liu, Xunbin Wei, and Xiaomei Wang

Subjects
Photon, Vascular imaging, Materials science, genetic structures, General Chemical Engineering, Nanoparticle, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Nuclear magnetic resonance, Materials Chemistry, sense organs, Aggregation-induced emission, 0210 nano-technology
Abstract

Fluorogens with aggregation-induced emission (AIEgens) are promising optical agents for cellular and vascular imaging. AIEgens with bright emission in the far-red and near-infrared (NIR) region is ...

Published
2020

4. Photosensitizer-Bacteria Biohybrids Promote Photodynamic Cancer Cell Ablation and Intracellular Protein Delivery

Author

Xueqi Li, Min Wu, Yukun Duan, Guobin Qi, Wenbo Wu, and Bin Liu

Subjects
Biocompatibility, biology, Intracellular protein, Chemistry, General Chemical Engineering, Cancer, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, medicine.disease, 01 natural sciences, 0104 chemical sciences, Cancer cell, Materials Chemistry, Cancer research, medicine, Photosensitizer, 0210 nano-technology, Gene, Bacteria
Abstract

Live bacteria have drawn widespread interest as carriers to deliver genes and proteins into eukaryotic cells for the treatment of various cancer types owing to their good biocompatibility and activ...

Published
2019

5. ONOO– and ClO– Responsive Organic Nanoparticles for Specific in Vivo Image-Guided Photodynamic Bacterial Ablation

Author

Duo Mao, Fang Hu, Deling Kong, Yukun Duan, Wenbo Wu, Xiaolei Cai, and Bin Liu

Subjects
inorganic chemicals, Fluorescence-lifetime imaging microscopy, Singlet oxygen, General Chemical Engineering, Nanoparticle, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, 01 natural sciences, Fluorescence, Acceptor, 0104 chemical sciences, chemistry.chemical_compound, chemistry, In vivo, Materials Chemistry, Photosensitizer, 0210 nano-technology, Phototoxicity
Abstract

Bacterial infection poses serious medical and public concerns. Herein, “33%IRTP” nanoparticles (NPs) are reported for in vivo bacterial infection detection and photodynamic treatment, serving as an alternative to antibiotic therapy. 33%IRTP nanoparticles have been developed by self-assembly of an ONOO– and ClO– responsive near-infrared dye “IR786S” and an amphiphilic polymer “TBD-PEG” containing a highly effective photosensitizer with aggregation-induced emission characteristics. As an energy acceptor, IR786S not only shows near-infrared emission for fluorescence imaging but also quenches both fluorescence and singlet oxygen generation of TBD-PEG, thus eliminating the phototoxicity of 33%IRTP nanoparticles in normal tissues. Once 33%IRTP NPs reach bacterial infection sites, IR786S could be decomposed by the overexpressed ONOO– and ClO– to turn on the red fluorescence and singlet oxygen generation of TBD-PEG, which offers image-guided photodynamic bacterial ablation. Considering their negligible in vivo da...

Published
2018

6. ONOO– and ClO– Responsive Organic Nanoparticles for Specific in Vivo Image-Guided Photodynamic Bacterial Ablation

Author

Wenbo Wu, Duo Mao, Xiaolei Cai, Yukun Duan, Fang Hu, Deling Kong, and Bin Liu

Subjects
*HYPOCHLORITES, *NANOPARTICLES, *MOLECULAR self-assembly, *PHOTODYNAMIC therapy, *CLUSTERING of particles, *PHOTOSENSITIZERS
Abstract

Bacterial infection poses serious medical and public concerns. Herein, “33%IRTP” nanoparticles (NPs) are reported for in vivo bacterial infection detection and photodynamic treatment, serving as an alternative to antibiotic therapy. 33%IRTP nanoparticles have been developed by self-assembly of an ONOO– and ClO– responsive near-infrared dye “IR786S” and an amphiphilic polymer “TBD-PEG” containing a highly effective photosensitizer with aggregation-induced emission characteristics. As an energy acceptor, IR786S not only shows near-infrared emission for fluorescence imaging but also quenches both fluorescence and singlet oxygen generation of TBD-PEG, thus eliminating the phototoxicity of 33%IRTP nanoparticles in normal tissues. Once 33%IRTP NPs reach bacterial infection sites, IR786S could be decomposed by the overexpressed ONOO– and ClO– to turn on the red fluorescence and singlet oxygen generation of TBD-PEG, which offers image-guided photodynamic bacterial ablation. Considering their negligible in vivo dark toxicity, 33%IRTP nanoparticles demonstrate great potential in antibacterial applications. [ABSTRACT FROM AUTHOR]

Published
2018
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