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Anise, or Pimpinella anisum, has a long history of usage in traditional and alternative medicine, as well as in the pharmaceutical sector.The species is native to Southwest Asia, the Middle East, and the Mediterranean region. The current studies have revealed that wild and cultivated P. anisumare rich in bioactive compounds, such as phenols, tannins, carotenoids, and fatty acids. Different parts of P. anisumplant are used treatment of diseases, the treatment of pathogens for antiviral, antibacterial, and antifungal purposes, and cosmetics. In this paper, we reviewed the current knowledge on geographical distribution, cultivation, chemical compounds, extraction methods, and agronomic and medicinal uses of Pimpinella anisum. Equally, we suggested guidelines for future research to fill the gap in less investigated issues. Data for this paper was gathered via electronic literature search on Google, Google Scholar, and databases counting, Science Direct, Scopus, Springer, PubMed, and Hindawi, from 1930 to 2022. Analyzed data show that Pimpinella anisumis currently recorded from Portugal on the Atlantic Ocean in the west to China in the East. With new extraction methods, such as Ultrasound-Assisted Extraction, scientists have explored the higher quantities of polyphenols, flavonoids, and antioxidants, and revealed new constituents such as trans-anethole and estragole found in essential oil fruits by gas chromatography-mass spectrometry (GC–MS). These compounds showed significant therapeutic benefits against diseases, pathogens, and cosmetic roles. However, with the current impacts of climate change on natural vegetation cover, more investigations are needed to understand how these affect the geographical distribution, metabolic aspects, and chemical properties of Pimpinella anisum.These are suggested to increase the value of the species and ensure its conservation.