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Start Over Author "Mathias Turberg" Journal chemistry (weinheim an der bergstrasse, germany)
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1. Mechanochemical Strecker Reaction: Access to α-Aminonitriles and Tetrahydroisoquinolines under Ball-Milling Conditions

Author

Ingo Schiffers, José G. Hernández, Mathias Turberg, and Carsten Bolm

Subjects
010405 organic chemistry, Chemistry, Organic Chemistry, Strecker amino acid synthesis, Potassium cyanide, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Mechanochemistry, Organic chemistry, Ball mill
Abstract

A mechanochemical version of the Strecker reaction for the synthesis of α-aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2 gave the corresponding α-aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker-type multicomponent reaction allowed the one-pot synthesis of tetrahydroisoquinolines after a subsequent internal N-alkylation reaction.

Published
2016

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