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Start Over Author "So, J" Journal chemischer informationsdienst
140,896 results on '"So, J"'

8. ChemInform Abstract: APORPHINES. 14. DOPAMINERGIC AND ANTINOCICEPTIVE ACTIVITY OF APORPHINE DERIVATIVES. SYNTHESIS OF 10-HYDROXYAPORPHINES AND 10-HYDROXY-N-PROPYLNORAPORPHINE

Author

John L. Neumeyer, J. F. Reinhard, W. P. Dafeldecker, D. S. Kosersky, K. Fuxe, L. Agnati, and J. Guarino

Subjects
Catechol, Chemistry, Stereochemistry, Dopaminergic, General Medicine, (+)-Naloxone, Aporphines, chemistry.chemical_compound, Nociception, Morphine, medicine, Aporphine, Receptor, medicine.drug
Abstract

The synthesis of racemic 10-hydroxyaporphine [(+/-)-2a] and 10-hydroxy-N-n-propylnoraporphine [(+/)-2b] is described. The method involved a Reissert alkylation-Pschorr cyclization route. The dopaminergic activity of (+/-)-2b was evaluated in comparison with L-Dopa, (-)-apomorphine (1a), (+/-)-N-n-propylnorapomorphine (NPA) (1b), and (+/-)-11-hydroxy-N-n-propylnoraporphine [(+/-)-11-OH-PNA] by the behavioral model of rotational behavior in animals after unilateral lesion of the ascending DA pathways. The dopaminergic activity of NPA and 11-OH-PNA is essentially equivalent to L-Dopa and (-)-apomorphine, and both are more active than (+/-)-2b. Furthermore, (+/-)-NPA (threshold doses, 5 mug/kg) appears to be even more potent that (-)-apomorphine (threshold doses, 25 mug/kg). The duration of action of NPA and 11-OH-PNA is considerably longer than that obtained with L-Dopa. The antinociceptive activity of (+/-)-2b was evaluated by the tail-flick procedure and compared with 1a, 2b, morphine, and L-Dopa. Weak but significant antinociceptive activity was shown by (+/-)-2b and by (+/-)-1b but not by (-)-apomorphine. This effect was not antagonized by naloxone. The finding that (+/-)-2b and particularly (+/-)-11-OH-PNA are active in doses from 500 to 50 mug/kg, respectively, in causing rotational behavior further supports previous studies indicating that N-n-propyl derivatives of monohydroxylated aporphines were more active than the corresponding parent N-methyl derivatives as DA receptor agonists and that a catechol system is not an absolute requirement for dopaminergic activity in such aporphines.

Published
1976
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15. ChemInform Abstract: MONOMETHYL AND DIMETHYL ETHERS OF METHYL β-D-XYLOPYRANOSIDE

Author

J. Jerabkova, J. Jary, and J. Jun. Stanek

Subjects
Chemistry, General Medicine, Medicinal chemistry
Abstract

Die partielle Methylierung des Xylosids (I) und chromatographische Trennung der gebildeten Produkte (IIIa)-(IIIg) stellt eine praparativ vorteilhaftere Methode zur Gewinnung dieser Ether dar als die mehrstufigen Synthesen der einzelnen Verbindun- i gen, wie sie in der Literatur beschrieben worden sind.

Published
1985
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17. ChemInform Abstract: OXANILIC ACIDS, A NEW SERIES OF ORALLY ACTIVE ANTIALLERGIC AGENTS

Author

Stanley C Bell, Charles J. Guinosso, John H. Sellstedt, Albert J. Begany, and Marvin E. Rosenthale

Subjects
Hydrolysis, chemistry.chemical_compound, Orally active, Chemistry, Antiallergic agent, Aryl, Oxanilic acid, Oxamic acid, Moiety, Organic chemistry, General Medicine, Passive Cutaneous Anaphylaxis
Abstract

A large number of oxanilic acid esters and N-heteroaryl oxamic acid esters were prepared and found to have antiallergic activity using the rat passive cutaneous anaphylaxis (PCA) test. Many of the oxanilic acid esters are active orally, with the most active species having an aryl 2'-carbamoyl group and a 3'-methoxy group. Hydrolysis of the ester from the oxanilic ester moiety causes a loss of oral activity.

Published
1976
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22. ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF SELECTED HETEROAROTINOIDS. PHARMACOLOGICAL ACTIVITY AS ASSESSED IN VITAMIN A DEFICIENT HAMSTER TRACHEAL ORGAN CULTURES. SINGLE-CRYSTAL X-RAY DIFFRACTION ANALYSIS OF 4,4-DIMETHYLTHIOCHROMAN-6-YL METHYL

Author

K. M. Waugh, Leonard J. Schiff, Warren T. Ford, P. R. Schomber, J. P. Carrol, K. D. Berlin, Elizabeth M. Holt, and Mark D. Thompson

Subjects
Vitamin, chemistry.chemical_compound, Chemistry, Stereochemistry, X-ray crystallography, Hamster, Biological activity, General Medicine, Single crystal
Published
1985
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34. ChemInform Abstract: DIMOLYBDENUM COMPLEXES CONTAINING BRIDGING SILYL-SUBSTITUTED ACETYLENES: CRYSTAL AND MOLECULAR STRUCTURE OF μ-BIS(TRIMETHYLSILYL)ACETYLENETETRACARBONYLBIS(η-CYCLOPENTADIENYL)DIMOLY# BDENUM(MO-MO)

Author

F. G. A. Stone, P. Woodward, S. A. R. Knox, Robert F. D. Stansfield, Mark J. Winter, and J. A. Beck

Subjects
Crystal, chemistry.chemical_compound, Bridging (networking), Trimethylsilyl, chemistry, Cyclopentadienyl complex, Silylation, Polymer chemistry, Molecule, General Medicine, Photochemistry
Published
1982
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48. ChemInform Abstract: Overtone Band Shapes and IVR: C-H Stretch Overtones in CHCl3

Author

Ian Mills, H. J. Clase, and J. E. Baggott

Subjects
Dye laser, Vibrational energy, Chemistry, Overtone, Intramolecular force, Photoacoustic imaging in biomedicine, Overtone band, Redistribution (chemistry), General Medicine, Molecular physics, Gas phase
Abstract

The intracavity photoacoustic dye laser spectrum of CHCl3 in the gas phase at 16 350 cm−1 is reported. The v=6–0 overtone of the CH stretch is observed, and found to exhibit a rotational band contour closely analogous to the v=1–0 fundamental. The implication of this result for intramolecular vibrational energy redistribution is discussed.

Published
1986
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