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Start Over Author "Richard S. Egan" Journal chemischer informationsdienst
17 results on '"Richard S. Egan"'

7. ChemInform Abstract: MODIFICATION OF THE 5′ POSITION OF PURINE NUCLEOSIDES. 2. SYNTHESIS AND SOME CARDIOVASCULAR PROPERTIES OF ADENOSINE-5′-(N-SUBSTITUTED)CARBOXAMIDES

Author

Milica Savic, Harold Brondyk, Dilbagh S. Bariana, K. Tietje, Anthony K. L. Fung, Richard S. Egan, Herman H. Stein, and Raj Nandan Prasad

Subjects
chemistry.chemical_classification, Purine, Stereochemistry, Carboxylic acid, Vasodilation, General Medicine, Adenosine, chemistry.chemical_compound, chemistry, Vasoactive, Nucleic acid, medicine, Intravenous route, Coronary sinus, medicine.drug
Abstract

We have shown previously that the esters of adenosine-5'-carboxylic acid (10) represent a new class of potent nontoxic coronary vasodilators. For example, the ethyl ester (12), which is active by an intraduodenal or intravenous route in dogs, causes a large increase in coronary sinus PO2 and coronary blood flow. Because of the pronounced vasoactive properties of the esters of adenosine-5'-carboxylic acid, a systematic study of the corresponding amides (14--50) was undertaken. In addition, several other analogues containing the N1-oxide function (51--52) or 2',3' substituents (3--9, 53--54) were studied.

Published
1980
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8. ChemInform Abstract: THE DEOXYDATIVE SUBSTITUTION OF PYRIDINE N-OXIDES. PART XVI. CARBON-13 SPECTRA OF SOME TETRAHYDROPYRIDINES. THE STRUCTURE OF THE TETRAHYDROPYRIDINES FROM 3,5-LUTIDINE 1-OXIDE AND MERCAPTANS IN ACETIC ANHYDRIDE

Author

Richard S. Egan, J. M. Kokosa, I. Chu, and Ludwig Bauer

Subjects
Acetic anhydride, chemistry.chemical_compound, chemistry, Pyridine, Carbon-13, Substitution (logic), Polymer chemistry, Oxide, Organic chemistry, General Medicine, Spectral line
Published
1979
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9. ChemInform Abstract: MINOR LANKAMYCIN-RELATED ANTIBIOTICS FROM STREPTOMYCES VIOLACEONIGER

Author

Jack Tadanier, Jerry R. Martin, Richard S. Egan, Ruth S. Stanaszek, Walter Keller-Schierlein, and Alma W. Goldstein

Subjects
Jones oxidation, Streptomyces violaceoniger, Biochemistry, Chemistry, medicine.drug_class, Yield (chemistry), Antibiotics, medicine, Lankamycin, Fermentation, General Medicine
Abstract

Several previously undescribed metabolites related to lankamycin have been isolated from fermentation broths of the lankamycin-producing organism Streptomyces violaceoniger. Two of these metabolites, of weak antibacterical activity, have been characterized as 15-O-(α-L-4-O-acetyl-arcanosyl)-lankamycin and 15-deoxy-15-oxo-lankamycin. The latter antibiotic is prepared in high yield by Jones oxidation of lankamycin.

Published
1978
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10. ChemInform Abstract: CHEMISTRY OF CHELOCARDIN. V. CONDENSATION WITH AMINO REAGENTS

Author

Ruth S. Stanaszek, David Lyon Garmaise, Stuart Nicholas Huckin, Daniel T. W. Chu, Edith Bernstein, and Richard S. Egan

Subjects
Chemistry, Reagent, Condensation, Organic chemistry, General Medicine, Chelocardin
Abstract

The nature of the products obtained from the reaction of chelocardin (1) and the model compound 2-acetyldimedone (5) with a variety of amines was investigated. It was observed that amines react wit...

Published
1981
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