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Start Over Author "Kurozumi, A." Journal chemischer informationsdienst
68 results on '"Kurozumi, A."'

2. ChemInform Abstract: SYNTHESIS OF NEW 7,13-DITHIAPROSTAGLANDINS

Author

Seizi Kurozumi, Yoshinobu Hashimoto, Takeshi Toru, and Kobayashi Makiko

Subjects
Cyclopentenone, chemistry.chemical_compound, Chemistry, Stereochemistry, Organic chemistry, General Medicine, Prostanoic acid, Sulfur containing, Derivative (chemistry)
Abstract

Much attention has been paid to heteroprostaglandins focusing on their different biological activities from those of the naturally occurring prostaglandins or other kinds of chemically modified prostanoic acids. Many laboratories have succeeded in the syntheses of 3-thia,1 7-thia,2 9-thia,3 11-thia,4 13-thia,5 3-oxa,1,6 7-oxa,7 9-oxa,8 10-oxa,9 11-oxa,10 8-aza,11 9-aza,12 12-aza,13 9,11-dioxa,14,15 9,11-dithia,15 8,12-diaza,16 9-aza-11-thia,17,18 and 9-aza-11-oxa18 prostanoids. Some of these heteroprostaglandins showed selective agonistic or antagonistic activities19 separating some biological activitites from undesired side-effects encountered in naturally occurring prostaglandins. Our laboratory has recently reported a synthesis of E-type 7-thiaprostaglandins from a new key intermediate, sulfur containing cyclopentenone derivative 3.20

Published
1977

12. ChemInform Abstract: Prostaglandin Chemistry. Part 29. Stereospecific Synthesis of (5E)-PGE2by Palladium-Catalyzed Decarboxylative 2-Alkenylation of 2-Alkenyloxycarbonylated Cyclopentanone Derivative

Author

Seizi Kurozumi, Okamura Noriaki, A. Hazato, Kiyoshi Bannai, Kenji Manabe, S. Sugiura, and Toshio Tanaka

Subjects
chemistry.chemical_compound, Stereospecificity, chemistry, chemistry.chemical_element, Organic chemistry, Prostaglandin, General Medicine, Cyclopentanone, Derivative (chemistry), Catalysis, Palladium
Published
1986

27. ChemInform Abstract: SYNTHESIS OF NEW ANTINEOPLASTIC PROSTAGLANDINS

Author

Atsuo Hazato, Kenji Manabe, S. Sugiura, Ryoji Noyori, K. Bannai, Seizi Kurozumi, Toshio Tanaka, Okamura Noriaki, and Takeshi Toru

Subjects
chemistry.chemical_compound, Chemistry, lipids (amino acids, peptides, and proteins), Tumor cells, General Medicine, Combinatorial chemistry, Enone, In vitro
Abstract

The three-component coupling process allows a single-pot entry to protected 7-hydroxy-PGE1 derivatives, leading to a variety of new PGs functionalized or unsaturated at C-7. The enone and dienone derivatives exhibit potent inhibitory activity on L1210 tumor cell growth in vitro.

Published
1985

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