Search

Your search keyword '"Yang Sheng"' showing total 171 results
Start Over Author "Yang Sheng" Journal cheminform
171 results on '"Yang Sheng"'

3. ChemInform Abstract: Geodisterol, a Novel Polyoxygenated Sterol with an Aromatic A Ring from the Tropical Marine Sponge Geodia sp

Author

Gui-Yang-Sheng Wang and Phil Crews

Subjects
Sponge, biology, Stereochemistry, Tropical marine climate, Chemistry, Geodia, General Medicine, Ring (chemistry), biology.organism_classification, Sterol
Abstract

Geodisterol ( 1 ), the first marine polyoxygenated sterol with an aromatic A ring, was isolated from the Indo-Pacific sponge Geodia sp. The structural and stereochemical features of 1 were based on the extensive analysis of 1D and 2D of it and MPA esters 2 and 3 .

Published
2010

5. ChemInform Abstract: SAR Studies of 3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one as Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase

Author

Shean-woei Lin, Jian-Lin Huang, Chung-Shieh Wu, Yung-lung Lin, Yang-Sheng Sun, and Ding-Yah Yang

Subjects
3-cyclopropanecarbonyloxy-2-cyclohexen-1-one, Chemistry, Dioxygenase, Stereochemistry, Potency, General Medicine, Pig liver, 4-Hydroxyphenylpyruvate dioxygenase
Abstract

Various 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one 1 derivatives have been synthesized and tested as inhibitors of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) from pig liver. The inhibition results indicated that well-positioned dicarbonyl groups as well as the cyclopropyl group of 1 were essential for potent inhibition. Substitution at the 2-position of the ring system has a significant effect on inhibitor potency, while the 5-position can undergo substantial variations and retain inhibitor potency. In the compounds examined, 2-chloro substituted 12 is the best inhibitor of all with IC 50 of 15 nM, the rest of the synthesized analogues were less potent inhibitors than the parent compound.

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results